ELECTRICAL STIMULATION FOR THE VESTIBULAR NERVE

电刺激前庭神经

• 批准号: 8357590
• 负责人: JAMES O PHILLIPS
• 金额: $ 15.66万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357590
• 关键词: Behavior; Cochlear Implants; Computer software; Devices; Electric Stimulation; Esthesia; Eye Movements; Funding; Gentamicins; Grant; Individual; Injection of therapeutic agent; Intermittent Vertigo; Labyrinth; Macaca mulatta; Meniere' s Disease; Modification; National Center for Research Resources; Nausea; Nerve; Neurons; Patients; Primates; Principal Investigator; Process; Research; Research Infrastructure; Resources; Semicircular canal structure; Source; Stimulus; Technology; United States National Institutes of Health; Vestibular Nerve; Vestibular loss; cost; response; vestibular prosthesis; visual image movement

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Currently there are limited treatment options for patients with pathological vestibular function. Loss of vestibular sensation from the inner ear results in imbalance and oscillopsia. Partial loss results in disequilibrium. Fluctuating loss in conditions such as Meniere's disease, results in intermittent vertigo and nausea. Our project was to develop an implantable vestibular prosthesis to replace lost vestibular function or correct abnormal vestibular function in patients suffering from these conditions. Specifically, we developed a modification of cochlear implant technology to provide the implantable portion of our device, and then developed new software and external hardware to drive individual semicircular canal nerves with electrical stimuli appropriate to produce reflexive eye movement responses in rhesus monkeys. We then recorded from individual vestibular neurons to determine the central processing that takes place during stimulation to produce the observed behavior. We are now using transtympanic injections of gentamicin to eliminate vestibular input and then using electrical stimulation to compensate for the loss.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 目前，病理前庭功能患者的治疗选择有限。内耳的前庭感觉丧失会导致失衡和至止振荡。 部分损失导致不平衡。 梅尼尔氏病等疾病的波动损失导致间歇性眩晕和恶心。 我们的项目是开发一个可植入的前庭假体，以替代患有这些疾病的患者的前庭功能或正确的前庭功能。 具体而言，我们开发了对人工耳蜗技术的修改，以提供设备的植入部分，然后开发出新的软件和外部硬件，以驱动单个半圆形管神经，并具有适当的电刺激，以在恒河猴中产生反射性眼动运动反应。 然后，我们从单个前庭神经元记录下来，以确定刺激过程中发生的中心处理以产生观察到的行为。 现在，我们正在使用庆大霉素的三角胰蛋白酶注射来消除前庭输入，然后使用电刺激来补偿损失。