ELECTRICAL STIMULATION FOR THE VESTIBULAR NERVE

电刺激前庭神经

• 批准号: 7716376
• 负责人: JAMES O PHILLIPS
• 金额: $ 15.78万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716376
• 关键词: Behavior; Brain; Computer Retrieval of Information on Scientific Projects Database; Dizziness; Electric Stimulation; Equilibrium; Funding; Goals; Grant; Human; Implant; Institution; Labyrinth; Life; Macaca mulatta; Modification; Organ; Patients; Prosthesis; Research; Research Personnel; Resources; Source; Structure; Technology; United States National Institutes of Health; Vestibular Nerve

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our goal is to develop a viable implantable prosthesis to help patients with dizziness, balance and orientation problems to regain their mobility and active lives. To do this, the first step is to understand whether it is possible to implant a stimulating prosthesis in the vestibular end organ of the inner ear and obtain activation of the balance structures in the brain that is similar to the stimulation that occurs normally. Then, we must discover if the prosthesis can elicit behavior that similar to normal behavior. Finally, we must determine if the prosthesis can be used to substitute for natural stimulation when the vestibular end organ no longer functions normally. All of these steps, if performed in rhesus monkeys using modifications of existing human implant technology, can provide for a rapid progression toward implementation of a human prosthesis.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我们的目标是开发一个可行的植入植物假体，以帮助患有头晕，平衡和定向问题的患者重新获得流动性和积极的生活。 为此，第一步是了解是否有可能将刺激性假体植入内耳的前庭器官中，并获得大脑中平衡结构的激活，与正常发生的刺激相似。 然后，我们必须发现假体是否可以引起与正常行为相似的行为。 最后，我们必须确定当前庭末端器官不再正常起作用时，假体是否可以用来代替自然刺激。 如果所有这些步骤，如果使用现有人类植入技术的修改在恒河猴中进行，则可以为实施人类假体的实施而迅速发展。