RESTORING NORMAL FREQUENCY AND DURATION OF FEMALE SEXUAL BEHAVIOR

恢复女性性行为的正常频率和持续时间

• 批准号: 8173073
• 负责人: DAVID H ABBOTT
• 金额: $ 3.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173073
• 关键词: Affect; Animals; Behavioral; Biological Assay; Biological Models; Brain imaging; Callithrix; Callithrix jacchus jacchus; Clinical; Computer Retrieval of Information on Scientific Projects Database; Disease; Estrogens; Female; Frequencies; Funding; Grant; Grooming; Hormonal; Human; Institution; Intervention; Mammals; Neurons; Outcome; Pharmaceutical Preparations; Pharmacotherapy; Positron-Emission Tomography; Progestins; Property; Publications; Research; Research Personnel; Resources; Safety; Serotonin; Serotonin Agents; Serotonin Receptor Binding; Services; Sex Behavior; Sexual Dysfunction; Social Interaction; Source; System; United States National Institutes of Health; Woman; analog; flibanserin; improved; male; neuromechanism; nonhuman primate; relating to nervous system; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To improve our understanding of serotonin-related neural mechanisms regulating female sexual response in marmosets in order to develop more appropriate clinical intervention for sexual hypofunction in women. Sexual dysfunction affects an estimated 43% of women. Currently there are no approved drug therapies for this disorder. Safety concerns about hormonal treatment with estrogens and progestogens motivates the search for non-steroidal pharmoacotherapy. The serotonin neuronal system has been implicated in regulating sexual behavior in a range of female mammals, including humans and nonhuman primates, but the mechanisms involved are not well understood. We have developed a model system with female common marmosets to demonstrate that a serotonin analogue, 8-hydroxyDPAT, diminishes female acceptance of male sexual advances, while another, flibanserin, does not. Flibanserin also enhances positive social interactions between male-female pairs, including grooming. Non-invasive PET brain imaging suggests specific changes in female neural activity associated with the different behavioral outcomes for each serotonin drug. The different serotonin receptor binding properties of each drug are starting to provide clues as to neural mechanisms of action and theraputic application. Publications are pending. This research used WNPRC Assay Services and Animal Services.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 目的：提高我们对调节摩尔马群女性性反应的5-羟色胺相关神经机制的理解，以便为女性的性不良性不良临床干预开发更合适的临床干预。 性功能障碍影响估计有43％的女性。目前尚无针对这种疾病的批准药物疗法。对用雌激素和孕激素荷尔蒙治疗的安全问题激发了寻找非甾体类药物疗法的搜索。 5-羟色胺神经元系统与包括人类和非人类灵长类动物在内的一系列女性哺乳动物的性行为有关，但涉及的机制尚不清楚。我们已经开发了一种具有女性常见摩尔奶酪的模型系统，以证明5-羟色胺类似物（8-羟基型）会减少女性对男性性促进的接受，而另一个flibanserin却没有。 Flibanserin还增强了男女对之间的积极社会互动，包括修饰。非侵入性宠物脑成像表明，与每种5-羟色胺药物不同行为结果相关的女性神经活动的特定变化。每种药物的不同5-羟色胺受体结合特性开始提供有关作用和治疗应用神经机制的线索。出版物正在等待。 这项研究使用了WNPRC测定服务和动物服务。