RESTORING NORMAL FREQUENCY AND DURATION OF FEMALE SEXUAL BEHAVIOR

恢复女性性行为的正常频率和持续时间

• 批准号: 8173073
• 负责人: DAVID H ABBOTT
• 金额: $ 3.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173073
• 关键词: Affect; Animals; Behavioral; Biological Assay; Biological Models; Brain imaging; Callithrix; Callithrix jacchus jacchus; Clinical; Computer Retrieval of Information on Scientific Projects Database; Disease; Estrogens; Female; Frequencies; Funding; Grant; Grooming; Hormonal; Human; Institution; Intervention; Mammals; Neurons; Outcome; Pharmaceutical Preparations; Pharmacotherapy; Positron-Emission Tomography; Progestins; Property; Publications; Research; Research Personnel; Resources; Safety; Serotonin; Serotonin Agents; Serotonin Receptor Binding; Services; Sex Behavior; Sexual Dysfunction; Social Interaction; Source; System; United States National Institutes of Health; Woman; analog; flibanserin; improved; male; neuromechanism; nonhuman primate; relating to nervous system; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To improve our understanding of serotonin-related neural mechanisms regulating female sexual response in marmosets in order to develop more appropriate clinical intervention for sexual hypofunction in women. Sexual dysfunction affects an estimated 43% of women. Currently there are no approved drug therapies for this disorder. Safety concerns about hormonal treatment with estrogens and progestogens motivates the search for non-steroidal pharmoacotherapy. The serotonin neuronal system has been implicated in regulating sexual behavior in a range of female mammals, including humans and nonhuman primates, but the mechanisms involved are not well understood. We have developed a model system with female common marmosets to demonstrate that a serotonin analogue, 8-hydroxyDPAT, diminishes female acceptance of male sexual advances, while another, flibanserin, does not. Flibanserin also enhances positive social interactions between male-female pairs, including grooming. Non-invasive PET brain imaging suggests specific changes in female neural activity associated with the different behavioral outcomes for each serotonin drug. The different serotonin receptor binding properties of each drug are starting to provide clues as to neural mechanisms of action and theraputic application. Publications are pending. This research used WNPRC Assay Services and Animal Services.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 目的：提高对狨猴血清素相关调节雌性性反应的神经机制的认识，以便为女性性功能减退制定更合适的临床干预措施。 据估计 43% 的女性患有性功能障碍。目前还没有批准的药物治疗这种疾病。对雌激素和孕激素激素治疗的安全性担忧促使人们寻找非甾体药物疗法。血清素神经元系统与调节一系列雌性哺乳动物（包括人类和非人类灵长类动物）的性行为有关，但所涉及的机制尚不清楚。我们开发了一个雌性普通狨猴模型系统，以证明血清素类似物 8-羟基DPAT 会降低雌性对雄性性挑逗的接受度，而另一种氟班色林则不会。氟班色林还可以增强男女之间积极的社交互动，包括梳理毛发。非侵入性 PET 脑成像表明女性神经活动的特定变化与每种血清素药物的不同行为结果相关。每种药物不同的血清素受体结合特性开始为神经作用机制和治疗应用提供线索。出版物待定。 本研究使用了 WNPRC 检测服务和动物服务。