EFFECTIVE DETECTION OF PCOS IN OLD WORLD MONKEYS

有效检测旧世界猴子中的多囊卵巢综合症

基本信息

批准号：
8172467
负责人：
DAVID H ABBOTT
金额：
$ 2.19万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-05-01 至 2011-04-30
项目状态：
已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a translational multi-center project to initiate novel studies into the pathophysiological origins of a highly prevalent reproductive and metabolic disorder in women, namely polycystic ovary syndrome (PCOS). This hyperandrogenic syndrome increases a woman's lifetime risk of type 2 diabetes, cardiovascular disease, endometrial cancer and infertility. Our focus on PCOS stems from the highly pervasive, but heterogeneous nature of the disease, and our incomplete understanding of its etiology in women. We now need a naturally-occurring phenotype in a nonhuman primate model as well as an ability to target children at risk of PCOS to develop novel clinical interventions to prevent or diminish the adult PCOS phenotype. In this pilot project begun in late Fall 2009, we propose to establish the efficacy of both nonhuman primate and human approaches with a consortium of multiple Primate Centers and the Wisconsin CTSA. Our targeted use of appropriate nonhuman primate populations and expertise at three Primate Centers minimizes redundancies in resources available nationally and our utilization of Assay Services within the WCTSA demonstrates our sharing of a single core resource. Thus far, the Yerkes Center has collected samples and performed ovarian ultrasounds on some 20 of the 100 females needed. All samples will be sent to Dr Abbott at the WNPRC for analyses.

该子项目是利用该技术的众多研究子项目之一资源由 NIH/NCRR 资助的中心拨款提供。子项目和研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金，因此可以在其他 CRISP 条目中表示。列出的机构是对于中心来说，它不一定是研究者的机构。这是一个多中心转化项目，旨在对女性中高度流行的生殖和代谢疾病（即多囊卵巢综合征（PCOS））的病理生理学起源进行新的研究。这种高雄激素综合征会增加女性终生患 2 型糖尿病、心血管疾病、子宫内膜癌和不孕症的风险。我们对多囊卵巢综合症的关注源于这种疾病的高度普遍性和异质性，以及我们对其女性病因的不完全了解。我们现在需要非人类灵长类动物模型中自然发生的表型，以及针对有 PCOS 风险的儿童的能力，以开发新的临床干预措施来预防或减少成人 PCOS 表型。在这个于 2009 年秋末开始的试点项目中，我们建议与多个灵长类动物中心和威斯康星州 CTSA 组成的联盟一起确定非人类灵长类动物和人类方法的有效性。我们在三个灵长类动物中心有针对性地使用适当的非人类灵长类动物种群和专业知识，最大限度地减少了全国可用资源的冗余，并且我们对 WCTSA 内检测服务的利用表明我们共享单一核心资源。到目前为止，耶基斯中心已收集了所需的 100 名女性中的约 20 名样本并进行了卵巢超声检查。所有样本将被送往 WNPRC 的 Abbott 博士进行分析。