NATURALLY-OCCURRING POLYCYSTIC OVARY SYNDROME (PCOS) IN NONHUMAN PRIMATES

非人类灵长类动物自然发生的多囊卵巢综合症 (PCOS)

• 批准号: 8173165
• 负责人: DAVID H ABBOTT
• 金额: $ 3.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173165
• 关键词: Animals; Biological Assay; Biomedical Research; Computer Retrieval of Information on Scientific Projects Database; Disease; Etiology; Funding; Grant; Heritability; Incidence; Individual; Institution; Macaca; Metabolic Diseases; Modeling; Monkeys; Pilot Projects; Polycystic Ovary Syndrome; Population; Prevalence; Primates; Research; Research Personnel; Resources; Services; Source; United States National Institutes of Health; base; nonhuman primate; reproductive; trait

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To determine the incidence and phenotypic traits of polycystic ovary syndrome (PCOS) in nonhuman primate populations at three US Primate Centers. This pilot project will determine the phenotypic traits and incidence of naturally occurring PCOS in two species of macaque monkeys commonly used as biomedical research models for reproductive and metabolic disorders. The project will provide an indication of heritability of individual traits, the prevalence of each trait within each of the two macaque monkey species, and will provide the basis for a more in-depth study to examine causation of the PCOS disorder in monkeys. This research relies on WNPRC Assay Services, CPI and Animal Services.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 目的：确定美国三个灵长类动物中心的非人类灵长类动物群体中多囊卵巢综合征 (PCOS) 的发病率和表型特征。 该试点项目将确定两种猕猴的表型特征和自然发生的多囊卵巢综合症的发病率，这两种猕猴通常用作生殖和代谢紊乱的生物医学研究模型。该项目将提供个体性状遗传性的指示，以及两种猕猴物种中每种性状的流行率，并将为更深入的研究提供基础，以检查猴子多囊卵巢综合症的病因。 这项研究依赖于 WNPRC 检测服务、CPI 和动物服务。