RESTORING NORMAL FREQUENCY AND DURATION OF FEMALE SEXUAL BEHAVIOR

恢复女性性行为的正常频率和持续时间

• 批准号: 7716416
• 负责人: DAVID H ABBOTT
• 金额: $ 8.19万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-23 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716416
• 关键词: Affect; Animals; Behavioral; Biological Assay; Biological Models; Callithrix; Callithrix jacchus jacchus; Clinical; Computer Retrieval of Information on Scientific Projects Database; Disease; Estrogens; Female; Frequencies; Funding; Grant; Hormonal; Human; Institution; Intervention; Mammals; Neurons; Pharmacotherapy; Progestins; Range; Research; Research Personnel; Resources; Serotonin; Services; Sex Behavior; Sexual Dysfunction; Source; System; United States National Institutes of Health; Woman; improved; neuromechanism; nonhuman primate; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To improve our understanding of serotonin-related neural mechanisms regulating female sexual response in marmosets in order to develop more appropriate clinical intervention for sexual hypofunction in women. Sexual dysfunction affects an estimated 43% of women. Currently there are no approved drug therapies for this disorder. Further concerns that hormonal treatment with estrogens and progestogens are not safe motivates the search for non-steroidal pharmoacotherapy. The serotonin neuronal system has been implicated in regulating sexual behavior in a range of female mammals, including humans and nonhuman primates, but the mechanisms involved are not well understood. We have developed a model system with female common marmosets to determine the behavioral responses to serotonergically active compounds. This research used WNPRC Assay Services and Animal Services.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 提高我们对狨猴中调节雌性性反应的血清素相关神经机制的理解，以便为女性性功能减退症制定更合适的临床干预措施。 据估计 43% 的女性患有性功能障碍。目前还没有批准的药物治疗这种疾病。进一步担心雌激素和孕激素激素治疗不安全，促使人们寻找非甾体药物疗法。血清素神经元系统与调节一系列雌性哺乳动物（包括人类和非人类灵长类动物）的性行为有关，但所涉及的机制尚不清楚。我们开发了一个雌性普通狨猴模型系统，以确定对血清素活性化合物的行为反应。本研究使用了 WNPRC 检测服务和动物服务。