The Inferior Colliculus as a Site of Electrical Stimulation

下丘作为电刺激部位

• 批准号: 7744636
• 负责人: DOUGLAS C FITZPATRICK
• 金额: $ 23.42万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-08 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7744636
• 关键词: Acoustic Nerve; Acoustics; Anesthesia procedures; Animals; Auditory; Auditory area; Behavior; Behavioral; Brain; Chronic; Cochlear Implants; Complex; Computer software; Cueing for speech; Cues; Development; Device or Instrument Development; Dimensions; Discrimination; Ear; Electric Stimulation; Electrodes; Frequencies; Future; Goals; Health Benefit; Hearing; Hearing Impaired Persons; Implant; Individual; Inferior Colliculus; Labyrinth; Longitudinal Studies; Measures; Michigan; Midbrain structure; Modeling; Neurons; Operative Surgical Procedures; Oryctolagus cuniculus; Pathway interactions; Patients; Pattern; Physiologic pulse; Physiological; Preparation; Procedures; Process; Prosthesis; Resolution; Shapes; Signal Transduction; Silicon; Site; Speech; Speech Discrimination; Staging; Stimulus; Testing; Time; Tissues; Trauma; Voice; Width; auditory stimulus; awake; base; improved; relating to nervous system; research study; response; tumor

DESCRIPTION (provided by applicant): In the last few decades, electrical stimulation of the inner ear has allowed a remarkable ability for deaf individuals to hear and understand speech. However, some patients cannot be helped by an implant placed in the ear due to the lack of auditory nerves, which can be either congenitally absent, damaged through trauma, or removed in surgery for tumors. In these patients, the only way to deliver acoustic information is through direct brain stimulation. A potential site for stimulation is the inferior colliculus (IC) in the midbrain. The IC is major site for the convergence of auditory information prior to its representation in the cortex. The current study will measure the physiological and behavioral responses to electrical stimulation of the IC in rabbits. The stimuli will include speech cues known to be discriminable by animals. The hypothesis is that patterns of electrical stimulation based on the responses of IC neurons to auditory stimuli will improve the physiological and behavioral discrimination of the speech cues compared to stimulation patterns used for cochlear implants. The experiments will test the ability to achieve functional hearing by stimulation of the inferior colliculus, a major center for auditory integration in the brain. The expected health benefits include future development of devices, software and treatments that assist the deaf and hearing impaired.

描述（由申请人提供）：在过去的几十年中，对内耳的电刺激使聋人听到和理解语音的能力显着。但是，由于缺乏听觉神经，在耳朵上放置的植入物无法帮助某些患者，这可能是先天性缺失，通过创伤受损或在肿瘤手术中切除。在这些患者中，传递声学信息的唯一方法是通过直接的大脑刺激。潜在的刺激部位是中脑的下丘（IC）。该IC是听觉信息在其在皮质中表示之前的主要站点。当前的研究将衡量兔子对IC的电刺激的生理和行为反应。刺激将包括可以被动物区分的言语提示。假设是，与用于耳蜗植入物使用的刺激模式相比，基于IC神经元对听觉刺激的反应的电刺激模式将改善语音线索的生理和行为歧视。实验将测试通过刺激下丘的刺激（大脑听觉整合中心）来实现功能听力的能力。预期的健康益处包括未来开发设备，软件和治疗方法，可以帮助聋人和听力受损。