Infections, immunity, and inflammation in cancer

癌症中的感染、免疫和炎症

• 批准号: 7981279
• 负责人: Eric A Engels
• 金额: $ 135.88万
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7981279
• 关键词: Acquired Immunodeficiency Syndrome; Address; Affect; Autoimmune Diseases; Autoimmunity; Breast; Bronchi; Categories; Chlamydophila pneumoniae; Chronic; Development; Disease; End stage renal failure; Environment; Genes; Genetic; Helicobacter pylori; Hepatitis C virus; Human; Human Genetics; Human Herpesvirus 4; Human Papillomavirus; Immune; Immunity; Immunosuppression; Infection; Inflammation; Lung; Malaria; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of penis; National Cancer Institute; Neuroblastoma; Non-Hodgkin' s Lymphoma; Organ Transplantation; Papillomavirus; Pathway interactions; Play; Pleura; Role; Serum Markers; Sexually Transmitted Diseases; Solid; Tissues; Trachea; Transplant Recipients; Viral Epidemiology; cancer epidemiology; cancer risk; cytokine; malignant stomach neoplasm; microbial; microbiome; molecular marker; population based

Infection, immune disturbances, and inflammation overlap in the ways that they damage tissues and promote development of cancer. Some studies in this project address the role of specific infections in cancer, including hepatitis C virus, Epstein Barr virus, and malaria in non-Hodgkin lymphoma; Helicobacter pylori in gastric cancer; Chlamydia pneumoniae in lung cancer; and human papillomavirus in penile cancer. Increasingly, it is recognized that microbial diversity (i.e., the microbiome) may play a role in influencing the tissue environment. Other studies examine how general disturbances of immunity may also facilitate development of cancer, such as occurs in solid organ transplant recipients or end stage renal disease. Finally, the project also includes studies to elucidate the role of inflammation as a pathway to cancer, such as caused by chronic infection or autoimmune diseases. The studies are human population-based. Some studies use molecular markers, such as gene markers, serum or tissue markers of infection, and cytokine levels indicating inflammation. Other studies evaluate human genetic polymorphisms that may affect inflammation and immunity and thereby modulate cancer risk..

感染、免疫紊乱和炎症在损害组织和促进癌症发展方面存在重叠。该项目中的一些研究探讨了特定感染在癌症中的作用，包括丙型肝炎病毒、EB 病毒和非霍奇金淋巴瘤中的疟疾；幽门螺杆菌在胃癌中的作用；肺癌中的肺炎衣原体；和阴茎癌中的人乳头瘤病毒。人们越来越认识到微生物多样性（即微生物组）可能在影响组织环境中发挥作用。其他研究探讨了免疫的一般紊乱如何也可能促进癌症的发展，例如实体器官移植受者或终末期肾病中发生的癌症。最后，该项目还包括阐明炎症作为癌症途径的作用的研究，例如由慢性感染或自身免疫性疾病引起的炎症。这些研究以人群为基础。一些研究使用分子标记，例如基因标记、感染的血清或组织标记以及指示炎症的细胞因子水平。其他研究评估了可能影响炎症和免疫从而调节癌症风险的人类遗传多态性。