Studies of HIV infection and its contribution to the natural history and outcome

HIV 感染及其对自然史和结果的贡献的研究

• 批准号: 10919024
• 负责人: Eric A Engels
• 金额: $ 347.55万
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10919024
• 关键词: Acquired Immunodeficiency Syndrome; Aging; Behavior; Chronic; Chronic Disease; Disease; Disparity; Etiology; General Population; HIV; HIV Infections; Health Services Accessibility; Hepatitis B Virus; Herpesviridae; Human Herpesvirus 4; Human Herpesvirus 8; Human Papillomavirus; Immunosuppression; Incidence; Individual; Infection; Inflammation; Intervention; Malignant Neoplasms; Natural History; Oncogenic Viruses; Outcome; Persons; Role; Socioeconomic Status; Tobacco smoking behavior; Virus; antiretroviral therapy; biomarker identification; cancer biomarkers; cancer diagnosis; cancer prevention; cancer therapy; immunosuppressed; improved; prevent; risk stratification; screening

People living with HIV have an elevated incidence of cancer due to a complicated range of issues related to AIDS-related immunosuppression, chronic inflammation, infection with oncogenic viruses, behavior factors including tobacco smoking, and poor socioeconomic status. Examples of important cancer-causing viruses include human papillomavirus (HPV), Epstein-Barr virus, Kaposi sarcoma-associated herpesvirus, and hepatitis viruses B and C. Studies of these factors in people living with HIV can contribute to understanding their role in other immunosuppressed individuals and in the general population. Many of these factors also contribute to poor access to treatment and disparities in outcomes following a cancer diagnosis. As people with HIV infection live longer with better antiretroviral therapies, they are aging, which is contributing to an increase in the burden of chronic diseases including cancer. There is a major need to develop improved cancer prevention, screening, and treatment for people living with HIV. This project includes multiple studies of cancer in people living with HIV.

由于与艾滋病相关的免疫抑制，慢性炎症，致癌病毒感染，包括烟草吸烟在内的行为因素以及社会经济状况不佳的行为因素，艾滋病毒患者的癌症发病率升高升高。重要的引起癌症病毒的例子包括人乳头瘤病毒（HPV），爱泼斯坦 - 巴尔病毒，卡波西肉瘤相关的疱疹病毒和乙型肝炎病毒B和C。对艾滋病毒患者的这些因素的研究可以有助于理解其在其他免疫抑制个体中的作用，并在其他免疫抑制者中的作用。这些因素中的许多因素也导致癌症诊断后的治疗和结果差异不佳。随着艾滋病毒感染患者的抗逆转录病毒疗法的寿命更长，他们正在衰老，这导致包括癌症在内的慢性疾病负担增加。对于艾滋病毒携带者的预防，筛查和治疗的主要需要，需要改善癌症。该项目包括艾滋病毒患者的多项癌症研究。