The Changing COVID-19 Landscape: A Feasibility Study to Capture Momentary Residential Environmental Exposures and Asthma Sypmtoms in Adults

不断变化的 COVID-19 形势：捕捉瞬时居住环境暴露和成人哮喘症状的可行性研究

• 批准号: 10250681
• 负责人: Kamal M Eldeirawi
• 金额: $ 25.71万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-15 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10250681
• 关键词: 2019-nCoV; Address; Adolescent; Adult; Advocate; Affect; Air; Air Pollutants; Area; Asthma; Behavior; COVID-19; COVID-19 pandemic; COVID-19 prevention; Cellular Phone; Chemical Exposure; Chemicals; Chicago; Child; Chronic; Communicable Diseases; Communities; Complex; Computer software; Coronavirus; Data; Data Collection; Data Reporting; Death Rate; Diagnosis; Direct Costs; Disease Outbreaks; Disinfectants; Ecological momentary assessment; Economic Burden; Elderly; Environmental Exposure; Environmental Impact; Environmental Monitoring; Environmental Risk Factor; Exposure to; Face; Facilities and Administrative Costs; Feasibility Studies; Frequencies; Future; Goals; Hand; Home; Home environment; Hour; Household; Housing; Hygiene; Individual; Indoor Air Quality; Indoor environment; Intervention; Lung diseases; Measures; Midwestern United States; Monitor; Notification; Nurses; Participant; Particulate; Particulate Matter; Patient Self-Report; Physicians; Population; Preventive measure; Public Health; Pulmonary Function Test/Forced Expiratory Volume 1; Quality-Adjusted Life Years; Readiness; Recommendation; Reporting; Research; Risk Factors; Risk Reduction; Schedule; Scientist; Self Management; Shelter facility; Spirometry; Surveys; Symptoms; Time; United States; Virus; Virus Diseases; age group; asthma exacerbation; base; cost; design; economic impact; environmental tobacco smoke; experience; fine particles; health economics; improved; innovation; member; pandemic disease; pollutant; pulmonary function; recruit; sensor; usability; volatile organic compound; willingness

ABSTRACT The global pandemic of coronavirus 2019 (COVID-19) is a substantial cause for concern among individuals with chronic respiratory diseases, including those with asthma. It is estimated that more than 60% of adults with asthma have uncontrolled symptoms and this represents a substantial health and economic impact. Compared to children, adults are nearly five times more likely to die from asthma and the asthma-related death rate is highest among those 65 years and older. Viral infections are a prominent risk factor for asthma exacerbation and, thus, SARS-CoV-2, the virus responsible for COVID-19, is cause for alarm among those diagnosed with asthma. Sheltering-in-place orders and recommendations, physical distancing, wearing face coverings, hand hygiene, and increased cleaning and disinfecting are primary COVID-19 preventative measures advocated. The effects of home-based strategies to prevent COVID-19, specifically increased residential exposure to cleaning/disinfecting agents and particulates on adults with asthma is unknown. Our long term goal is to characterize the impact of COVID-19 on existing asthma risk factors so as to develop tailored, home-based asthma interventions that adequately acknowledge COVID-19 and are responsive to the changing home environment and home routines resulting from this pandemic. The aims of this study are: 1) determine the feasibility and usability of: (a) ecological momentary assessment (EMA) to assess self-report residential environmental exposures and asthma symptoms, (b) home monitoring of objective environmental exposures (total volatile organic compounds [VOCs], particulates [PM2.5]), and lung function (home spirometry); 2a) assess the frequency and degree of residential environmental exposures (e.g., disinfectants/cleaners, second-hand smoke) via (a) self-reported data, and (b) home monitoring objective measures, 2b) assess the level of asthma control as indicated by self-reported asthma symptoms and lung function; and 3) explore associations of self-reported and objective measures of residential environmental exposures with self-reported and objective measures of asthma control. We will recruit 50 adults with asthma who completed our ongoing online COVID-19 and asthma survey, indicated willingness to be contacted for future studies, reported high use of disinfectant/cleaning products, and have not-well controlled asthma. Participants will receive an indoor air quality monitor and a home spirometer to measure VOCs, PM2.5, and FEV1% respectively. EMA will be collected using a personal smartphone and EMA software platform. Participants’ will be sent scheduled and random EMA notifications to assess asthma symptoms, environmental exposures, lung function, and mitigation strategies. After the 14-day data collection period, participants will respond to survey items related acceptability, appropriateness, and feasibility. Findings from this feasibility study will support a powered study to address the impact of environmental exposures related to COVID-19 and to enhance preparedness for future infectious disease outbreaks by developing innovative intervention strategies for those with asthma.

抽象的 2019 年冠状病毒 (COVID-19) 的全球大流行是引起个人担忧的重要原因 据估计，超过 60% 的成年人患有慢性呼吸道疾病，包括哮喘。 哮喘患者的症状不受控制，这对健康和经济产生了重大影响。 与儿童相比，成人死于哮喘的可能性高出近五倍，而与哮喘相关的疾病 65 岁及以上人群的死亡率最高，病毒感染是一个重要的危险因素。 哮喘恶化，因此 SARS-CoV-2（导致 COVID-19 的病毒）引起了人们的警惕 被诊断患有哮喘的人 就地避难的命令和建议、保持身体距离、穿着。 面罩、手部卫生以及加强清洁和消毒是主要的 COVID-19 预防措施 提倡的居家策略的效果尤其显着增强。 患有哮喘的成人在住宅中接触清洁/消毒剂和颗粒物的情况尚不清楚。 长期目标是确定 COVID-19 对现有哮喘危险因素的影响，以便制定 量身定制的、以家庭为基础的哮喘干预措施，充分认识到 COVID-19 并响应 这次流行病导致的家庭环境和家庭日常生活的改变本研究的目的是：1) 确定以下方面的可行性和可用性： (a) 生态瞬时评估（EMA）以评估自我报告 居住环境暴露和哮喘症状，(b) 客观环境的家庭监测 暴露（总挥发性有机化合物 [VOC]、颗粒物 [PM2.5]）和肺功能（家庭肺活量测定）； 2a) 评估住宅环境暴露的频率和程度（例如消毒剂/清洁剂、 二手烟）通过 (a) 自我报告数据，以及 (b) 家庭监测客观措施，2b) 评估 自我报告的哮喘症状和肺功能表明哮喘控制水平；3) 探索 住宅环境暴露的自我报告和客观测量与自我报告的关联 我们将招募 50 名完成我们正在进行的哮喘治疗的成年人。 在线 COVID-19 和哮喘调查，表明愿意联系未来的研究，报告高 使用消毒剂/清洁产品且哮喘控制不佳的参与者将接受室内治疗。 空气质量监测仪和家用肺活量计分别测量 VOC、PM2.5 和 FEV1%。 使用个人智能手机和 EMA 软件平台收集的信息将按计划发送。 随机 EMA 通知评估哮喘症状、环境暴露、肺功能和缓解情况 在 14 天的数据收集期结束后，参与者将对相关的调查项目做出回应。 该可行性研究的可接受性、适当性和可行性将支持有力的研究。 解决与 COVID-19 相关的环境暴露的影响并加强应对准备 通过为哮喘患者制定创新的干预策略来应对未来传染病的爆发。