Infections, immunity, and inflammation in cancer

癌症中的感染、免疫和炎症

• 批准号: 8157924
• 负责人: Eric A Engels
• 金额: $ 117.66万
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8157924
• 关键词: Immunity; Infection; Inflammation; Malignant Neoplasms

Infection, immune disturbances, and inflammation overlap in the ways that they damage tissues and promote development of cancer. Major studies under this project include the HIV/AIDS Cancer Match Study and Transplant Cancer Match Study, which link population-based registries of HIV infected people and transplant recipients to cancer registries in the U.S. Additional studies characterize risk factors for specific cancers in these immunosuppressed populations. Risk of non-Hodgkin lymphoma and lung cancer is elevated in immunosuppressed populations. Some studies under this project address the role of chronic infections, immune disturbance, and inflammation in these and other cancers.

感染，免疫障碍和炎症与损害组织并促进癌症的发展的方式重叠。该项目下的主要研究包括HIV/AIDS癌症匹配研究和移植癌症匹配研究，这些研究将基于人群的艾滋病毒感染者的注册和移植受者与美国的癌症注册人联系起来，更多的研究表征了这些免疫抑制人群中特定癌症的风险因素。在免疫抑制人群中，非霍奇金淋巴瘤和肺癌的风险升高。该项目下的一些研究介绍了这些和其他癌症中慢性感染，免疫障碍和炎症的作用。