Infections, immunity, and inflammation in cancer

癌症中的感染、免疫和炎症

• 批准号: 8565434
• 负责人: Eric A Engels
• 金额: $ 134.82万
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8565434
• 关键词: AIDS/HIV problem; Address; Autoimmunity; Case-Control Studies; Chronic; Development; Elderly; GB virus C; HIV; Hodgkin Disease; Human Papillomavirus; Immune; Immunity; Immunologic Epidemiology; Immunosuppression; Infection; Inflammation; Kaposi Sarcoma; Link; Malignant Neoplasms; Malignant neoplasm of anus; Malignant neoplasm of cervix uteri; Malignant neoplasm of liver; Malignant neoplasm of lung; Medicare; Multiple Myeloma; National Cancer Institute; Non-Hodgkin' s Lymphoma; Organ Transplantation; Population; Population-Based Registry; Renal carcinoma; Risk; Risk Factors; Role; Skin Carcinoma; Tissues; Transplant Recipients; Transplantation; cancer epidemiology; cancer genetics; cancer risk; data registry; immunosuppressed; interest; melanoma; neoplasm registry

Infection, immune disturbances, and inflammation overlap in the ways that they damage tissues and promote development of cancer. Major studies under this project include the HIV/AIDS Cancer Match Study and Transplant Cancer Match Study, which link population-based registries of HIV infected people and transplant recipients to cancer registries in the U.S. Additional studies characterize risk factors for specific cancers in these immunosuppressed populations. Risk of non-Hodgkin lymphoma and lung cancer is elevated in immunosuppressed populations. Other cancers of interest, because they are associated with HIV or organ transplant, include Kaposi sarcoma, liver cancer, cancers related to human papillomavirus (such as cervical cancer and anal cancer), Hodgkin lymphoma, melanoma, non-melanoma skin cancers, kidney cancer, and multiple myeloma. Some studies under this project address the role of chronic infections, immune disturbance, and inflammation in these and other cancers. One study under this project is a case-control study of GB virus C and non-Hodgkin lymphoma. Other studies, which focus on cancer risk in the elderly, involve analyses of linked SEER Medicare registry data.

感染、免疫紊乱和炎症在损害组织和促进癌症发展方面存在重叠。该项目下的主要研究包括艾滋病毒/艾滋病癌症匹配研究和移植癌症匹配研究，该研究将基于人群的艾滋病毒感染者和移植接受者登记处与美国的癌症登记处联系起来。其他研究描述了这些免疫抑制人群中特定癌症的危险因素。免疫抑制人群患非霍奇金淋巴瘤和肺癌的风险较高。其他感兴趣的癌症，因为它们与艾滋病毒或器官移植有关，包括卡波西肉瘤、肝癌、与人乳头瘤病毒相关的癌症（例如宫颈癌和肛门癌）、霍奇金淋巴瘤、黑色素瘤、非黑色素瘤皮肤癌、肾癌和多发性骨髓瘤。该项目下的一些研究探讨了慢性感染、免疫紊乱和炎症在这些癌症和其他癌症中的作用。该项目下的一项研究是 GB 病毒 C 和非霍奇金淋巴瘤的病例对照研究。其他关注老年人癌症风险的研究涉及对相关 SEER 医疗保险登记数据的分析。