Novel Glaucoma Diagnostics for Structure and Function

新型青光眼结构和功能诊断

基本信息

批准号：
7487755
负责人：
Joel S Schuman
金额：
$ 44.42万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-09-30 至 2010-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7487755
关键词：
Address Axon Biological Boston Characteristics Clinical Computers Contralateral Data Detection Devices Diagnostic Discrimination Early Diagnosis Engineering Enrollment Evaluation Eye Funding Future Glaucoma Image Imaging Device Imaging technology Institutes Lasers Lead Massachusetts Measurement Measures Medical center Nerve Fibers New England Onset of illness Ophthalmologist Ophthalmoscopy Optic Disk Optic Nerve Optical Coherence Tomography Participant Patients Perimetry Process Range Reproducibility Research Research Design Research Priority Research Project Grants Resolution Retinal Retinal Ganglion Cells Scanning Scientist Speed Staging Structure Subgroup Suspect Glaucomas Techniques Technology Testing Tissues Translational Research Treatment Effectiveness Universities Vision Vision research Visual Fields Visual evoked cortical potential base cohort density eye center follow-up image registration improved indexing instrument macula medical schools member multidisciplinary neuronal cell body novel optic nerve disorder polarimetry prospective prototype research and development research study retinal nerve fiber layer technology development

项目摘要

DESCRIPTION: Our broad, long term objective continues to be the development of technologies for precisely measuring optic nerve and retinal changes that will enable early detection of glaucoma and of glaucoma progression. This translational research project is a collaborative effort of our multidisciplinary team of ophthalmologists, engineers, computer scientists and physicists at the University of Pittsburgh, Tufts University School of Medicine, Massachusetts Institute of Technology and Carnegie Mellon University. Our Specific Aims are (1) To detect the earliest possible evidence of glaucomatous damage and progression through objective, quantitative structural and functional assessment. We will compare ocular structural measurements (OCT, CSLO, SLP) and ocular function measurements (perimetry and multifocal visual evoked potential) using the historical and prospective examinations on the subgroups in our long-term longitudinal Boston cohort and new longitudinal prospective examinations on our Pittsburgh cohort. We expect that changes detected with structural measures will precede those detected with functional techniques. (2) To determine whether a synergistic index of correspondence, that combines structural and perimetric data, accelerates the ability to detect perimetric abnormality or progression in glaucoma. This prospective experiment will evaluate the ability of combined structural and functional correspondence indices to reliably predict visual field results in early to moderate glaucoma patients. Such an index could reduce or eliminate the need for confirmatory perimetric testing in the future and (3) To advance micron-scale tomographic imaging using OCT measurement technology for early detection of glaucoma and for more sensitive discrimination of progression. A new, high speed, high resolution instrument that we have developed provides about 1-3 mu m axial resolution at 16,000 axial scans per second. We will evaluate in healthy, suspect and glaucomatous subjects the ability of this and other technologic strategies that we are developing - including, tracking-OCT and spectral-domain-OCT - to provide even better image registration, measurement reproducibility and discriminating power. This project addresses the Strategic Research Priorities stated in the National Plan for Vision Research, to ".. .develop improved diagnostic measures to detect optic nerve disease onset, progression, and treatment effectiveness."

描述：我们广泛的长期目标仍然是开发精确测量视神经和视网膜变化的技术，从而能够及早发现青光眼和青光眼进展。该转化研究项目是匹兹堡大学、塔夫茨大学医学院、麻省理工学院和卡内基梅隆大学的眼科医生、工程师、计算机科学家和物理学家组成的多学科团队的共同努力。我们的具体目标是 (1) 通过客观、定量的结构和功能评估，尽早发现青光眼损伤和进展的证据。我们将使用我们长期纵向波士顿队列中亚组的历史和前瞻性检查以及匹兹堡的新纵向前瞻性检查来比较眼部结构测量（OCT、CSLO、SLP）和眼功能测量（视野检查和多焦点视觉诱发电位）队列。我们预计通过结构措施检测到的变化将先于通过功能技术检测到的变化。 (2) 确定结合结构数据和视野数据的对应协同指数是否可以加速检测青光眼视野异常或进展的能力。这项前瞻性实验将评估结构和功能对应指数相结合可靠预测早期至中度青光眼患者视野结果的能力。这样的指数可以减少或消除未来对验证性视野检查的需要，并且(3)使用OCT测量技术推进微米级断层扫描成像，以早期检测青光眼并更灵敏地辨别进展。我们开发的新型高速高分辨率仪器可在每秒 16,000 次轴向扫描的情况下提供约 1-3 μm 的轴向分辨率。我们将在健康、可疑和青光眼受试者中评估该技术以及我们正在开发的其他技术策略（包括跟踪 OCT 和谱域 OCT）的能力，以提供更好的图像配准、测量再现性和辨别能力。该项目涉及国家视觉研究计划中规定的战略研究重点，“……开发改进的诊断措施来检测视神经疾病的发病、进展和治疗效果。”