Novel Glaucoma Diagnostics for Structure and Function

新型青光眼结构和功能诊断

• 批准号: 7487755
• 负责人: Joel S Schuman
• 金额: $ 44.42万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7487755
• 关键词: Address; Axon; Biological; Boston; Characteristics; Clinical; Computers; Contralateral; Data; Detection; Devices; Diagnostic; Discrimination; Early Diagnosis; Engineering; Enrollment; Evaluation; Eye; Funding; Future; Glaucoma; Image; Imaging Device; Imaging technology; Institutes; Lasers; Lead; Massachusetts; Measurement; Measures; Medical center; Nerve Fibers; New England; Onset of illness; Ophthalmologist; Ophthalmoscopy; Optic Disk; Optic Nerve; Optical Coherence Tomography; Participant; Patients; Perimetry; Process; Range; Reproducibility; Research; Research Design; Research Priority; Research Project Grants; Resolution; Retinal; Retinal Ganglion Cells; Scanning; Scientist; Speed; Staging; Structure; Subgroup; Suspect Glaucomas; Techniques; Technology; Testing; Tissues; Translational Research; Treatment Effectiveness; Universities; Vision; Vision research; Visual Fields; Visual evoked cortical potential; base; cohort; density; eye center; follow-up; image registration; improved; indexing; instrument; macula; medical schools; member; multidisciplinary; neuronal cell body; novel; optic nerve disorder; polarimetry; prospective; prototype; research and development; research study; retinal nerve fiber layer; technology development

DESCRIPTION: Our broad, long term objective continues to be the development of technologies for precisely measuring optic nerve and retinal changes that will enable early detection of glaucoma and of glaucoma progression. This translational research project is a collaborative effort of our multidisciplinary team of ophthalmologists, engineers, computer scientists and physicists at the University of Pittsburgh, Tufts University School of Medicine, Massachusetts Institute of Technology and Carnegie Mellon University. Our Specific Aims are (1) To detect the earliest possible evidence of glaucomatous damage and progression through objective, quantitative structural and functional assessment. We will compare ocular structural measurements (OCT, CSLO, SLP) and ocular function measurements (perimetry and multifocal visual evoked potential) using the historical and prospective examinations on the subgroups in our long-term longitudinal Boston cohort and new longitudinal prospective examinations on our Pittsburgh cohort. We expect that changes detected with structural measures will precede those detected with functional techniques. (2) To determine whether a synergistic index of correspondence, that combines structural and perimetric data, accelerates the ability to detect perimetric abnormality or progression in glaucoma. This prospective experiment will evaluate the ability of combined structural and functional correspondence indices to reliably predict visual field results in early to moderate glaucoma patients. Such an index could reduce or eliminate the need for confirmatory perimetric testing in the future and (3) To advance micron-scale tomographic imaging using OCT measurement technology for early detection of glaucoma and for more sensitive discrimination of progression. A new, high speed, high resolution instrument that we have developed provides about 1-3 mu m axial resolution at 16,000 axial scans per second. We will evaluate in healthy, suspect and glaucomatous subjects the ability of this and other technologic strategies that we are developing - including, tracking-OCT and spectral-domain-OCT - to provide even better image registration, measurement reproducibility and discriminating power. This project addresses the Strategic Research Priorities stated in the National Plan for Vision Research, to ".. .develop improved diagnostic measures to detect optic nerve disease onset, progression, and treatment effectiveness."

描述：我们广泛的长期目标仍然是精确测量视神经和视网膜变化的技术的发展，这将使能够早期检测青光眼和青光眼进展。这个转化研究项目是我们的多学科研究团队，匹兹堡大学，塔夫茨大学医学院，马萨诸塞州科技研究所和卡内基·梅伦大学的多学科团队。我们的具体目的是（1）通过客观的，定量的结构和功能评估来检测青光眼损害和进展的最早证据。我们将使用对长期纵向波士顿同类群的亚组进行的历史和前瞻性检查，比较眼部结构测量（OCT，CSLO，SLP）和眼功能测量（近距离和多焦点视觉诱发电位）。我们希望通过结构测量检测到的变化将在功能技术检测到的变化之前。 （2）确定结合结构和周日数据的对应关系的协同指数是否会加速检测青光眼中周围异常或进展的能力。该前瞻性实验将评估结构和功能对应指数可靠地预测视野在早期至中度青光眼患者中的视野结果的能力。这样的指数将来可以减少或消除对确认性周期测试的需求，并且（3）使用OCT测量技术提高微米级层析成像，以及早检测青光眼和对进展的更敏感的歧视。我们开发的一种新的高速，高分辨率仪器可提供约1-3 mu m轴向分辨率，每秒16,000轴向扫描。我们将在健康，可疑和青光眼受试者中评估我们正在开发的这种技术和其他技术策略的能力，包括跟踪-OCT和光谱域-OCT，以提供更好的图像注册，测量可重复可重复性和歧视能力。该项目探讨了国家视觉研究计划中规定的战略研究优先事项，“ ..开发改进了诊断措施，以检测视神经疾病的发作，进展和治疗效果”。