Clinical glaucoma management enabled by visible-light OCT

可见光 OCT 实现临床青光眼管理

• 批准号: 10696088
• 负责人: Joel S Schuman
• 金额: $ 63.19万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10696088
• 关键词: Address; Adoption; Age; Algorithms; Anatomy; Angiography; Anterior; Area; Biological Markers; Biological Sciences; Biomedical Engineering; Blood Vessels; Blood capillaries; Caring; Cells; Clinical; Clinical Management; Collaborations; Color; Data; Dendrites; Detection; Diagnosis; Disease; Doppler Ultrasound; Eye; Floor; Foundations; Functional Imaging; Glaucoma; Goals; Hemoglobin; Human; Image; Imaging technology; Inner Plexiform Layer; Interdisciplinary Study; Lasers; Measurement; Measures; Mechanics; Medicine; Metabolic; Methodology; Modality; Morphologic artifacts; Motion; Ophthalmoscopes; Optical Coherence Tomography; Optical Tomography; Oxygen; Pathogenesis; Pathway interactions; Patients; Process; Protocols documentation; Research; Resolution; Retina; Retinal Ganglion Cells; Rodent; Sampling; Scanning; Scientist; Structure; Synapses; System; Techniques; Technology; Thick; Time; Tissues; Traction; Ultrafine; Variant; Visible Radiation; Visualization; arteriole; clinical care; clinical imaging; clinical translation; computerized data processing; data acquisition; data reduction; design; early detection biomarkers; healthy volunteer; image processing; imaging capabilities; imaging modality; improved; machine learning method; metabolic imaging; meter; neurotoxic; programs; research clinical testing; retinal imaging; theories; tool; ultra high resolution; venule

Project Summary This collaborative technology focused project seeks to develop, characterize, and validate visible-light optical coherence tomography (vis-OCT) as a functional tool to transform the clinical management of glaucoma. We will address two unmet needs in clinical glaucoma diagnosis and detection of progression: (1) the ability to measure retinal sublayer structure and (2) to accurately assess local retinal hemoglobin oxygen saturation (sO2). The earliest structural changes in glaucoma are thought to be a retraction of retinal ganglion cell (RGC) dendrites in the inner plexiform layer (IPL). Specifically, this would occur in the outer IPL, where RGC “off” cells synapse. Identification of loss of synapses, either by decreased scattering or by the change in IPL sublayers’ thicknesses, could serve as an earlier and more sensitive biomarker for glaucoma than any other. Measuring retinal sO2 and specific arteriole-venule couplets can determine the oxygen extraction in the regions served by those vessels. Our preliminary data indicate that regions showing damage in glaucomatous eyes have lower oxygen extraction than similar areas in healthy eyes. Our observation suggests that such oxygen extraction abnormalities can be measured well beyond the “floor effect” threshold noted with conventional OCT, allowing assessment of disease beyond the time point that conventional structural OCT becomes insensitive. To achieve our long-term goal, we will focus on new vis-OCT optical system design, imaging protocols, and data processing methodologies to identify both metabolic and ultra-fine anatomical alternations in early glaucoma, both of which are beyond the capabilities of existing imaging technologies.

项目摘要 这个以协作技术为重点的项目旨在开发，表征和验证可见光光学 相干断层扫描（Vis-OCT）是转化青光眼临床管理的功能工具。我们将 解决临床青光眼诊断和进展检测的两个未满足的需求：（1）测量能力 视网膜子层结构和（2）准确评估局部视网膜血红蛋白氧饱和度（SO2）。 青光眼最早的结构变化被认为是视网膜神经节细胞（RGC）树突中的缩回 内丛状层（IPL）。具体而言，这将发生在RGC“ OFF”细胞突触的外部IPL中。 通过下降或通过IPL Sublayers厚度的变化来识别突触丧失， 比其他任何人都可以作为青光眼的早期生物标志物。测量视网膜SO2和 特定的小动脉 - 结与夫妇可以确定这些血管所服务区域的氧气提取。 我们的初步数据表明，在青光眼眼睛中显示损害的区域的氧气提取较低 比健康的眼睛中的类似区域。我们的观察表明，这种氧气提取异常可能是 远远超出了常规OCT指出的“地板效应”阈值，允许评估疾病 除了传统结构OCT变得不敏感的时间点之外。为了实现我们的长期目标，我们 将专注于新的Vis-OCT光学系统设计，成像协议和数据处理方法 在早期青光眼中确定代谢和超细解剖替代方案，这两者都超出了 现有成像技术的功能。