Clinical glaucoma management enabled by visible-light OCT

可见光 OCT 实现临床青光眼管理

• 批准号: 10487592
• 负责人: Joel S Schuman
• 金额: $ 63.19万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10487592
• 关键词: Address; Adoption; Age; Algorithms; Anatomy; Angiography; Anterior; Area; Back; Biological Markers; Biological Sciences; Biomedical Engineering; Blood Vessels; Blood capillaries; Caring; Cells; Clinical; Clinical Management; Color; Data; Dendrites; Detection; Diagnosis; Disease; Doppler Ultrasound; Eye; Floor; Foundations; Functional Imaging; Glaucoma; Goals; Hemoglobin; Human; Image; Imaging technology; Inner Plexiform Layer; Interdisciplinary Study; Lasers; Measurement; Measures; Mechanics; Medicine; Metabolic; Methodology; Modality; Morphologic artifacts; Motion; Ophthalmoscopes; Optical Coherence Tomography; Optics; Oxygen; Pathogenesis; Pathway interactions; Patients; Process; Protocols documentation; Research; Resolution; Retina; Retinal Ganglion Cells; Rodent; Sampling; Scanning; Scientist; Structure; Synapses; System; Techniques; Technology; Thick; Time; Tissues; Ultrafine; Variant; Visible Radiation; arteriole; clinical care; clinical imaging; clinically translatable; computerized data processing; data acquisition; design; early detection biomarkers; healthy volunteer; image processing; imaging capabilities; imaging modality; improved; machine learning method; metabolic imaging; neurotoxic; programs; research clinical testing; retinal imaging; theories; tool; ultra high resolution; venule

Project Summary This collaborative technology focused project seeks to develop, characterize, and validate visible-light optical coherence tomography (vis-OCT) as a functional tool to transform the clinical management of glaucoma. We will address two unmet needs in clinical glaucoma diagnosis and detection of progression: (1) the ability to measure retinal sublayer structure and (2) to accurately assess local retinal hemoglobin oxygen saturation (sO2). The earliest structural changes in glaucoma are thought to be a retraction of retinal ganglion cell (RGC) dendrites in the inner plexiform layer (IPL). Specifically, this would occur in the outer IPL, where RGC “off” cells synapse. Identification of loss of synapses, either by decreased scattering or by the change in IPL sublayers’ thicknesses, could serve as an earlier and more sensitive biomarker for glaucoma than any other. Measuring retinal sO2 and specific arteriole-venule couplets can determine the oxygen extraction in the regions served by those vessels. Our preliminary data indicate that regions showing damage in glaucomatous eyes have lower oxygen extraction than similar areas in healthy eyes. Our observation suggests that such oxygen extraction abnormalities can be measured well beyond the “floor effect” threshold noted with conventional OCT, allowing assessment of disease beyond the time point that conventional structural OCT becomes insensitive. To achieve our long-term goal, we will focus on new vis-OCT optical system design, imaging protocols, and data processing methodologies to identify both metabolic and ultra-fine anatomical alternations in early glaucoma, both of which are beyond the capabilities of existing imaging technologies.

项目概要 这个以技术为重点的合作项目旨在开发、表征和验证可见光光学 相干断层扫描（vis-OCT）作为一种功能性工具来改变青光眼的临床管理。 解决临床青光眼诊断和进展检测中两个未满足的需求：（1）测量的能力 视网膜亚层结构；(2) 准确评估局部视网膜血红蛋白氧饱和度 (sO2)。 青光眼最早的结构变化被认为是视网膜神经节细胞（RGC）树突的回缩。 具体来说，这会发生在外层 IPL，即 RGC“关闭”细胞突触的地方。 通过减少散射或改变 IPL 子层厚度来识别突触损失， 与测量视网膜 sO2 相比，它可以作为青光眼的更早、更敏感的生物标志物。 特定的小动脉-小静脉对可以确定这些血管所服务区域的氧气提取量。 我们的初步数据表明，青光眼眼睛受损的区域的氧气提取量较低 我们的观察表明，这种吸氧异常可能是由健康眼睛的类似区域引起的。 测量结果远远超出传统 OCT 指出的“地板效应”阈值，从而可以评估疾病 超越传统结构 OCT 变得不敏感的时间点 为了实现我们的长期目标，我们。 将专注于新的 vis-OCT 光学系统设计、成像协议和数据处理方法 识别早期青光眼的代谢和超精细解剖学改变，这两者都超出了 现有成像技术的能力。