Miniature Capnometer

微型二氧化碳计

基本信息

批准号：
7404697
负责人：
GREGORY ZELTSER
金额：
$ 37.35万
依托单位：
PHYSICAL OPTICS CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-04-01 至 2010-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7404697
关键词：
Accident and Emergency department Acute Affect Air Ambulances Anesthesiology Architecture Atmospheric Pressure Be++ element Beryllium Blood capillaries Caliber Calibration Capnography Carbon Dioxide Cardiovascular system Caring Child Compatible Computer software Condition Depth Development Devices Disadvantaged Electric Wiring Elements Engineering Ensure Equipment Exhalation Experimental Animal Model Eye Fiber Optics Financial compensation Gases Goals Health Hospitals Humidity Hypercapnia Hypocapnia Immune Individual Infant Lasers Length Light Lung Mainstreaming Measurement Measures Mechanical ventilation Medical Membrane Metabolic Monitor Mucous body substance Nitrous Oxide Nose Nursing Homes Operative Surgical Procedures Optics Oryctolagus cuniculus Outpatients Oxygen Partial Pressure Patients Performance Phase Placement Polymers Polypropylenes Process Production Reaction Time Reader Reading Recovery Rehabilitation therapy Research Resolution Respiratory Diaphragm Respiratory System Sampling Shock Silicones Speed Survival Rate System Technology Temperature Testing Therapeutic Thick Tidal Volume Time Traction Transducers Tube Validation Ventilator Water Weaning Weight barometric pressure base capillary computerized data processing concept cost design endotracheal improved innovation medical schools novel optical fiber portability pressure prototype respiratory response sensor size success tool

项目摘要

DESCRIPTION (provided by applicant): Infrared carbon dioxide monitors, both mainstream and sidestream, have drawbacks: addition of a dead space, slow system response, and erroneous readings caused by the presence of nitrous oxide or oxygen, and by varying barometric pressure. To avoid the major shortcomings of existing capnometers, Physical Optics Corporation (POC) developed a proof-of-concept prototype Miniature Capnometer (MIC). The MIC is 2 mm in diameter, robust, and sensitive. It fits easily into the endotracheal tube, or into a sampling line of non-intubated patients. The device is immune to interference from other gases exhaled by the patient, to atmospheric pressure, and to humidity, and it has high carbon dioxide resolution and accuracy, and short response time. In Phase I we experimentally demonstrated MIC feasibility by fabricating a prototype and testing its parameters with a precise gas mixing system. In Phase II we will optimize the system design and performance parameters, and conduct in-depth testing during pressure and volume controlled conventional mechanical ventilation of rabbits with intact lungs under conditions of normocapnia, hypocapnia, and hypercapnia. The proposed miniature capnometer will overcome the major shortcomings of the existing infrared carbon dioxide monitors, including addition of a dead space, slow system response, and erroneous readings caused by the presence of nitrous oxide and oxygen, as well as varying brometric pressure. The proposed capnometer will be a robust, sensitive, and accurate tool for both hospital and pre-hospital applications, which will improve the treatment success and patient survival rate, all of which will contribute to public and individual health.

描述（由申请人提供）：主流和侧词的红外二氧化碳监测器具有缺点：添加死空间，缓慢的系统响应以及由一氧化二氮或氧气的存在引起的错误读数，以及通过变化的气压。为了避免现有旋翼仪的主要缺点，物理光学公司（POC）开发了概念验证原型微型胶囊（MIC）。麦克风的直径为2 mm，稳健且敏感。它很容易拟合到气管导管中，或者融入非插管患者的采样系列。该设备不受患者呼出的其他气体的干扰，大气压和湿度，并且具有较高的二氧化碳分辨率和准确性，并且响应时间短。在第一阶段，我们通过制造原型并通过精确的气体混合系统测试其参数来实验证明MIC可行性。在第二阶段，我们将优化系统的设计和性能参数，并在正常pa，低碳酸盐和超脑症的条件下，在压力和体积控制的常规机械通气期间进行兔子完整肺的常规机械通气。所提出的微型帽仪将克服现有红外二氧化碳监测器的主要缺点，包括增加死空间，缓慢的系统响应以及由于一氧化二氮和氧气以及多种元素压力而引起的错误读数。拟议的胶囊表将是医院和院前应用的强大，敏感和准确的工具，这将提高治疗成功和患者的生存率，所有这些都将有助于公共和个人健康。