Effect Of Diet and Other Early Exposures on Child Health

饮食和其他早期暴露对儿童健康的影响

• 批准号: 7169663
• 负责人: Matthew P Longnecker
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7169663
• 关键词: chronic disease /disorder; clinical research; cryptorchidism; dentistry; developmental neurobiology; developmental nutrition; dietary constituent; disease /disorder proneness /risk; endocrinology; environmental exposure; human subject; mother /embryo /fetus nutrition; nutrition related tag; questionnaires; racial /ethnic difference; reproductive hormone

Diet and other early exposures may affect child development and the risk of several chronic diseases, but additional research is needed. The current research described in this "catch-all" project comprises two subprojects: first, a study of effects due to exposures incurred secondary to dental procedures and treatments during pregnancy, and second, a group of inter-related studies all having to do with hormone levels in women during pregnancy in relation to factors such as race and cryptorchidism in offspring, which are risk factors for testicular germ cell tumors. The study of effects due to exposures incurred secondary to dental procedures and treatments during pregnancy is based on data from the Avon Longitudinal Study of Parents and Children. Data on dental history were available for 8,251 women and the outcomes examined were birth weight, preterm birth, and child's communicative development. Regarding the studies of hormone levels during pregnancy, these were all nested in the Collaborative Perinatal Project (CPP--see description under project ES049016). Stored serum from pregnant women was analyzed for hormone levels and examined in relation to subject characteristics. Last year's progress: A manuscript describing the dental study was prepared and will be submitted to a journal shortly. Two papers on hormone levels in pregnancy were published, and one was submitted to a journal.

饮食和其他早期暴露可能会影响儿童发育和几种慢性疾病的风险，但还需要进行更多研究。 这个“包罗万象”的项目中描述的当前研究包括两个子项目：第一个是对怀孕期间牙科手术和治疗继发的暴露影响的研究，第二个是一组相互关联的研究，所有这些研究都与女性怀孕期间的激素水平与种族和后代隐睾等因素有关，这些因素是睾丸生殖细胞肿瘤的危险因素。 对怀孕期间牙科手术和治疗继发暴露影响的研究基于雅芳家长和儿童纵向研究的数据。我们提供了 8,251 名女性的牙科病史数据，检查的结果包括出生体重、早产和儿童的沟通发育。 关于怀孕期间激素水平的研究，这些都属于围产期合作项目（CPP——参见项目 ES049016 下的描述）。对储存的孕妇血清进行激素水平分析，并检查其与受试者特征的关系。 去年的进展： 描述牙科研究的手稿已准备就绪，并将很快提交给期刊。发表了两篇关于妊娠期激素水平的论文，其中一篇已提交给期刊。