Prenatal Exposure to Endocrine Disrupting Chemicals and Risk of Testicular Cancer (DISRUPT)

产前接触内分泌干扰化学物质与睾丸癌 (DISRUPT) 的风险

基本信息

批准号：
10373985
负责人：
Anders Juul
金额：
$ 26.18万
依托单位：
REGION HOVEDSTADEN
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-04-15 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10373985
关键词：
Address Adolescence Adult Age Amniotic Fluid Analytical Chemistry Androgens Animal Model Appearance Attention Biological Biometry Birth Blood Body mass index Caucasians Chemical Exposure Chemicals Clinical Collection Confounding Factors (Epidemiology)Country Cryptorchidism Data Denmark Developed Countries Development Diagnosis Elderly Endocrine Disruptors Endocrine disruption Endocrinology Environmental Exposure Environmental Pollutants Epidemiology Epigenetic Process Equilibrium Estrogens Ethnic Origin Etiology European Exposure to Family Family history of Fetal Development Fetus Funding Opportunities Gene Expression General Population Gold Guidelines Health Healthcare Histologic Homeostasis Hormones Human Incidence Individual Knowledge Life Life Style Malignant Neoplasms Malignant neoplasm of testis Masculine Maternal Exposure Measures Mission Mothers National Institute of Environmental Health Sciences Notification Occupations Outcome Persons Play Polychlorinated Biphenyls Population Pregnancy Pregnant Women Proxy Puberty Questionnaires Recording of previous events Registries Reproductive Health Research Research Project Grants Research Proposals Risk Risk Factors Role Sampling Scientist Serum Son Specific qualifier value System TNM Time Triclosan United States National Institutes of Health Weight Woman aged base cancer risk case control cohort cost effective disease registry epidemiologic data epidemiology study fetal in utero infancy male men modifiable risk multidisciplinary neoplasm registry novel offspring organ growth organochlorine pesticide phthalates pregnant prenatal prenatal exposure programs prospective rare condition reproductive reproductive organ trend young adult young man

项目摘要

§ Project Summary Testicular cancer, although rare in the general population, represents around 60% of all cancers in young men aged 20-40 years. Its incidence has increased several-fold during the 20th century, but reasons for this are largely unknown. Established risk factors include cryptorchidism, Caucasian ethnicity as well as family history of testicular cancer and scientists strongly suspect that environmental exposures particularly during fetal development may play a role. The endocrine disruption hypothesis suggests that exposure to endocrine disrupting chemicals (EDCs) during fetal development disrupts normal reproductive organ development associated with long-term adverse reproductive effects, including testicular cancer. Despite heightened con- cern and tremendous scientific and public attention during the past 20 years, epidemiological data are still sparse. The conditions rarity in the population, long lag time between the sensitive period during fetal de- velopment and clinical appearance and lack of appropriate animal models for testicular cancer have hin- dered the understanding of the factors involved in the development of this cancer and few if any studies have quantified prenatal exposure to EDCs and were unable to address risk of testicular cancer from fetal exposures. Therefore, there is a need for epidemiological based research with reliable data based on expo- sure assessment quantified in biological prenatal samples, which are considered the gold standard. The objective of the present proposal is to address this knowledge gap using a cohort of 128,702 women who provided blood and amniotic fluid samples during their pregnancies in the period 1976-96. By registry link- age within highly reliable national population and disease registries for ascertainment for outcome/poten- tial confounders we will identify all sons diagnosed with testicular cancer (including sub-types) and match each of these at the time of their diagnosis to two control sons (n=550 sons) using risk set sampling. Levels of EDCs including DDT, DDE and other organochlorine pesticides, PCBs, PBDEs, PFAS, phthalates and triclosan will be quantified in prenatal biosamples from mothers. This study is important in relation to the overall mission of the National Institute of Environmental Health Sciences and will contribute substan- tially to the weight of the evidence in support of or against the fetal programing hypothesis with respect to testicular cancer and environmental EDCs. No similar research has been carried out in the US. Elucidating the association between relevant environmental EDCs and testicular cancer may reveal potentially modifia- ble risk factors, leading to guidelines for pregnant women so they can take sensible measures to reduce their own exposures.

§ 项目摘要虽然在普通人群中很少见，但约占年轻癌症的60％男性20-40岁。它的事件在20世纪增加了几倍，但原因是在很大程度上未知。既定的风险因素包括隐性主义，高加索种族和家庭测试癌症的历史和科学家强烈怀疑环境暴露尤其是在胎儿发育可能起作用。内分泌干扰假设表明暴露于内分泌胎儿发育过程中破坏化学物质（EDC）破坏了正常生殖器官的发育与长期不良生殖作用有关，包括结论癌。尽管有所增加在过去的20年中，CERN以及极大的科学和公众关注，流行病学数据仍然疏。人口稀有性的条件，胎儿敏感时期之间的较长时间滞后时间速度和临床外观以及缺乏适当的测试癌动物模型具有对这种癌症发展所涉及的因素的理解，没有任何研究已经量化了产前暴露于EDC，无法解决胎儿的证据癌的风险暴露。因此，有必要基于博士学位的数据，并基于博士学位确保在被认为是黄金标准的生物产前样品中量化的评估。这本提案的目的是使用128,702名妇女的队列来解决这一知识差距 1976 - 96年期间，在怀孕期间提供了血液和羊水样品。通过注册表链接 - 高度可靠的全国人口和疾病登记处的年龄，以确定结果/ 我们将确定所有被诊断为测试癌症（包括子类型）和匹配的儿子这些都在诊断为两个对照儿子（n = 550个儿子）时，都使用风险集抽样。水平包括DDT，DDE和其他有机氯农药，PCB，PBDE，PFA，PFA，邻苯二甲酸酯和邻苯二甲酸酯和其他有机氯的EDC 三氯生将在母亲的产前生物样本中进行量化。这项研究与美国国家环境健康科学研究所的整体任务，将贡献在支持或反对胎儿编程假设的证据的重量方面睾丸癌和环境EDC。在美国没有进行类似的研究。阐明相关环境EDC与测试癌症之间的关联可能揭示危险因素，导致孕妇准则，因此她们可以采取明智的措施来减少其自己的暴露。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Presence of parabens, phenols and phthalates in paired maternal serum, urine and amniotic fluid.

DOI：
10.1016/j.envint.2021.106987
发表时间：
2022-01
期刊：
Environment international
影响因子：
11.8
作者：
Bräuner EV;Uldbjerg CS;Lim YH;Gregersen LS;Krause M;Frederiksen H;Andersson AM
通讯作者：
Andersson AM

Evaporation of serum after long-term biobank storage: A chemical analysis of maternal serum from a large Danish pregnancy screening registry.

DOI：
10.1371/journal.pone.0293527
发表时间：
2023
期刊：
PloS one
影响因子：
3.7
作者：
通讯作者：

Is male gynaecomastia associated with an increased risk of death? A nationwide register-based cohort study.

DOI：
10.1136/bmjopen-2023-076608
发表时间：
2024-01-16
期刊：
BMJ OPEN
影响因子：
2.9
作者：
Brauner, Elvira, V;Uldbjerg, Cecilie;Lim, Youn-Hee;Beck, Astrid;Hueg, Trine;Juul, Anders
通讯作者：
Juul, Anders

Maternal Serum α-Fetoprotein Levels during Pregnancy and Testicular Cancer in Male Offspring: A Cohort Study within a Danish Pregnancy Screening Registry.

DOI：
10.3390/ijerph192114112
发表时间：
2022-10-28
期刊：
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
影响因子：
0
作者：
Uldbjerg, Cecilie S.;Lim, Youn-Hee;Glazer, Clara H.;Hauser, Russ;Juul, Anders;Brauner, Elvira, V
通讯作者：
Brauner, Elvira, V

Self-Reported Asthma Is Associated with Reduced Sperm Count-A Cross-Sectional Study of More than 6000 Young Men from the General Population.

DOI：
10.3390/life13020278
发表时间：
2023-01-19
期刊：
LIFE-BASEL
影响因子：
3.2
作者：
Pedersen, Marc K.;Brauner, Elvira V.;Hansen, Ann H.;Hansen, Laura S.;Jensen, Tina K.;Jorgensen, Niels;Priskorn, Laerke
通讯作者：
Priskorn, Laerke