STUDIES OF PHENOLPHTHALEIN CONTAINING LAXATIVE USE AND NEOPLASIA

含酚酞缓泻剂使用与肿瘤的研究

• 批准号: 6432321
• 负责人: Matthew P Longnecker
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6432321
• 关键词: cancer risk; clinical research; colorectal neoplasms; drug carcinogenesis; drug related neoplasm /cancer; human subject; laxative; ovary neoplasms; phenols

Aims: Phenolphthalein, a constituent in many laxatives, showed clear evidence of carcinogenic activity in 2-year feeding studies in rodents recently completed by the National Toxicology Program (NTP). About 3% of the older U.S. population uses phenolphthalein-containing laxatives on a daily basis. We will investigate the relation of phenolphthalein-containing laxative use with risk of ovarian cancer and adenomatous colorectal polyps in humans. Accomplishments: We established collaborative agreements with the principal investigators for two case-control studies of risk factors for ovarian cancer. At our instigation, these investigators inserted into their questionnaire a 2-page addition that ascertains use of specific phenolphthalein-containing laxatives. A report from the first such study is in press and data from the remaining study (300 cases and 300 controls) will be ready for analysis in 2000. The report in press shows no association of phenolphthalein-containing laxative use and risk of ovarian cancer Data on laxative use were available to us from two case-control studies of risk factors for adenomatous colorectal polyps. We examined laxative use in relation to risk of polyps in these data. The association of polyps with use of all laxatives and phenolphthalein-containing laxatives was specifically explored after taking into account dietary and other risk factors for colorectal adenomas. Results from the two studies were inconsistent with each other but overall offered little support for an association between phenolphthalein-containing laxative use and risk of polyps. The report was published in 1997.

目的：国家毒理学计划 (NTP) 最近完成的啮齿类动物为期 2 年的喂养研究中，酚酞是许多泻药的成分，显示出明显的致癌活性。 大约 3% 的美国老年人每天使用含酚酞的泻药。 我们将研究含酚酞泻药的使用与人类卵巢癌和腺瘤性结直肠息肉风险的关系。成就：我们与主要研究人员就两项卵巢癌危险因素的病例对照研究建立了合作协议。 在我们的怂恿下，这些研究人员在调查问卷中插入了 2 页的补充内容，以确定特定的含酚酞泻药的使用情况。 第一项此类研究的报告已出版，其余研究（300 个病例和 300 个对照）的数据将于 2000 年准备好进行分析。已出版的报告表明使用含酚酞泻药与卵巢癌风险之间没有关联。我们从两项关于腺瘤性结直肠息肉危险因素的病例对照研究中获得了关于泻药使用的信息。 我们在这些数据中检查了泻药的使用与息肉风险的关系。 在考虑饮食和结直肠腺瘤的其他危险因素后，专门探讨了息肉与使用所有泻药和含酚酞泻药的关系。 这两项研究的结果彼此不一致，但总体而言，几乎没有支持含酚酞泻药的使用与息肉风险之间的关联。 该报告于1997年发表。