STUDIES OF PHENOLPHTHALEIN CONTAINING LAXATIVE USE AND NEOPLASIA

含酚酞缓泻剂使用与肿瘤的研究

• 批准号: 6106678
• 负责人: Matthew P Longnecker
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6106678
• 关键词: cancer risk; clinical research; colorectal neoplasms; drug carcinogenesis; drug related neoplasm /cancer; human subject; laxative; ovary neoplasms; phenols

Summary of Work: Phenolphthalein, a constituent in many laxatives, showed clear evidence of carcinogenic activity in 2-year feeding studies in rodents recently completed by the National Toxicology Program (NTP). About 3% of the older U.S. population uses phenolphthalein-containing laxatives on a daily basis. We will investigate the relation of phenolphthalein-containing laxative use with risk of ovarian cancer and adenomatous colorectal polyps in humans. We have established collaborative agreements with the principal investigators for two ongoing case-control studies of risk factors for ovarian cancer. At our instigation, these investigators have inserted into their questionnaire a 2-page addition that ascertains use of specific phenolphthalein-containing laxatives. Each study will yield about 300 cases and 300 controls, and the data will be ready for analysis in 1999. Data collection for two case-control studies of risk factors for adenomatous colorectal polyps have been completed. Data on laxative use were available for both studies. We have examined laxative use in relation to risk of polyps in these data. The association of polyps with use of all laxatives and phenolphthalein-containing laxatives was specifically explored after taking into account dietary and other risk factors for colorectal adenomas. Results from the two studies were inconsistent with each other but overall offered little support for an association between phenolphthalein-containing laxative use and risk of polyps.

工作总结：酚酞，一种成分 许多泻药，显示出明显的致癌活性证据 国家卫生研究院最近完成了为期 2 年的啮齿动物喂养研究 毒理学计划（NTP）。大约 3% 的美国老年人 人们每天使用含酚酞的泻药 基础。我们将研究酚酞含量的关系 使用泻药有患卵巢癌和腺瘤性结直肠癌的风险 人类息肉。我们已建立合作协议 与主要研究人员一起进行两个正在进行的病例控制 卵巢癌危险因素的研究。在我们的怂恿下，这些 研究人员在调查问卷中插入了 2 页 确定使用特定含酚酞的添加物 泻药。每项研究将产生约 300 个病例和 300 个对照， 数据将于 1999 年准备好用于分析。 两项结直肠腺瘤危险因素的病例对照研究 息肉已经完成。可获得有关泻药使用的数据 对于这两项研究。我们研究了泻药使用与风险的关系 这些数据中的息肉。息肉与使用所有药物的关联 泻药和含酚酞的泻药 在考虑了饮食和其他危险因素后进行了探索 结直肠腺瘤。这两项研究的结果是 彼此不一致，但总体而言对 使用含酚酞泻药与 息肉的风险。