HUMAN HEALTH EFFECTS OF EXPOSURE TO ORGANOCHLORINE COMPOUNDS

接触有机氯化合物对人类健康的影响

• 批准号: 6432322
• 负责人: Matthew P Longnecker
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6432322
• 关键词: African American; clinical research; dichlorodiphenyltrichloroethane; embryo /fetus toxicology; environment related neoplasm /cancer; environmental toxicology; halobiphenyl /halotriphenyl compound; human subject; neoplasm /cancer epidemiology; outcomes research; pesticide biological effect

Aims: Persistent halogenated organic pollutants (e.g., DDT, PCBs [polychlorinated biphenyls], dioxin) command special attention in public health because they are ubiquitous in the ecosystem and may be causing adverse human health effects at background levels of exposure, via diet. We are conducting several studies of the human health effects of background exposure to organochlorines. Accomplishments: We have completed field work on a case-control study of serum p,p'-DDE (a metabolite of DDT) and PCB levels in relation to risk of breast cancer among African-American women in Los Angeles. Laboratory results are complete (300 cases and 300 controls), and the data are being prepared for analysis and will be ready for analysis in 2000. Our main project is an investigation of health effects of in utero exposure to organochlorine residues among participants in the Collaborative Perinatal Project, for whom a specimen bank (mother's serum) is available. Associations being examined are: 1) mother's p,p'-DDE levels in relation to risk of hypospadias, cryptorchidism, and polythelia in male offspring, 2) mother's PCB level in relation to child's neurodevelopmental outcomes, hearing, and IQ, 3) mother's DDE level in relation to body habitus in adolescence in male offspring. Laboratory analyses are now complete for over 2,500 subjects and the data are being cleaned for analysis, which will begin in 2000. We also examined in utero PCB exposure in relation to neonatal thryoid function in the North Carolina cohort study of effects of early-life organochlorine exposure. We have collaborated with investigators from the Air Force Health Study to examine health effects of dioxin exposure, including diabetes. We are beginning work on a study of the effect of the antiandrogen DDE on anthropometric measures at birth among neonates from a highly exposed population in Mexico.

目的：持续性卤代有机污染物（例如DDT，PCB，多氯联苯[二苯基]，二恶英）在公共卫生中特别关注，因为它们在生态系统中无处不在，并且可能通过饮食在背景水平上引起人类健康影响不良。 我们正在对背景暴露于有机氯的人类健康影响进行多项研究。成就：我们已经完成了一项针对血清P，P'-DDE（DDT代谢物）和PCB水平的病例对照研究的现场工作，该研究与洛杉矶非裔美国妇女的乳腺癌风险有关。 实验室结果是完整的（300例和300个对照），并且正在准备数据进行分析，并准备在2000年进行分析。我们的主要项目是对子宫内的健康影响的调查，在协作围产期项目中参与者中有机氯残基的健康影响，为此提供了标本库（母亲的血清）。 正在检查的关联是：1）母亲的P，P'-DDE水平与男性后代的催生风险，隐式术和多核心有关，2）母亲的PCB水平与儿童的神经发育成果，听力，听力，觉得和IQ，IQ，IQ，IQ，IQ，IQ，3）母亲的DDE水平相对于身体习惯，在身体习惯中均缩短了男性习惯。 现在，针对2500多名受试者进行了实验室分析，并且正在清理数据以进行分析，该分析将于2000年开始。我们还研究了北卡罗来纳州北卡罗来纳州同胞研究的新生儿thryoid功能的子宫PCB暴露研究，研究了早期生命的有机氯暴露的作用。我们已经与空军健康研究的研究人员合作，研究了包括糖尿病在内的二恶英暴露的健康影响。我们开始研究抗二氧化碳DDE对墨西哥高度暴露人群的新生儿对人体测量指标的影响。