ORGANOCHLORINE RESIDUE LEVELS AND RISK OF BREAST CANCER

有机氯残留水平和乳腺癌风险

• 批准号: 2156187
• 负责人: Matthew P Longnecker
• 金额: $ 18.9万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 1998-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2156187
• 关键词: African American; blood chemistry; blood lipid; breast neoplasms; cancer risk; chemical carcinogen; chemical related neoplasm /cancer; chlordane; chlorohydrocarbon insecticide; dichlorodiphenyltrichloroethane; dioxins; environmental toxicology; female; halobiphenyl /halotriphenyl compound; human middle age (35-64); human subject; insecticide biological effect; interview; pesticide interaction; statistics /biometry; women's health; young adult human (21-34)

Organochlorine compounds such as DDT and PCB are detectable in the blood of most Americans. These compounds have been designated as possibly or probably carcinogenic by the International Agency for Research on Cancer. Some recent reports suggest that risk of breast cancer is proportional to exposure to DDE, a degradation product of DDT, and to PCB. These reports were each based on fewer than 60 cases. Results from another, larger study suggest no associations exist; additional data are needed. African- Americans have had greater exposure to DDE than white Americans, thus an examination of the DDE-breast cancer association in African-Americans may have greater statistical power to detect an effect than studies in lesser- exposed populations. We propose to conduct a case-control study to test the hypothesis that levels of organochlorine residues in serum are associated with increased risk of breast cancer among African-American women. The study will be added on to ongoing study funded by the National Institute of Child Health and Development. The ongoing study, the Women's Contraceptive and Reproductive Experience (CARE) study, is a multi-center population-based case-control study being conducted among women aged 35-64 in five areas of the U.S., including Los Angeles County. For the present study, we will enroll a subset of the African-American participants in Los Angeles County. Cases will be identified through the Los Angeles County Cancer Surveillance Program (a SEER cancer registry).. Controls will be selected by random-digit dialing. After subjects have completed interviews for the Women's CARE study, they will be asked to provide a blood specimen for the present study. We will obtain blood from 300 African-American breast cancer cases and 300 controls and measure serum organochlorine residues (DDE, PCBs, heptachlor epoxide, oxychlordane, trans-nonachlor, dieldrin, HCB, and beta-BHC) and total lipids using standard methods. Serum residue levels will be examined in relation to odds of breast cancer in multivariate unconditional logistic regression models.

在血液中可检测到有机氯化合物，例如DDT和PCB 大多数美国人。 这些化合物已被指定为可能或 国际癌症研究机构可能会致癌。 最近的一些报告表明，乳腺癌的风险与 暴露于DDE的DDE，DDT的降解产物和PCB。 这些报告 每个基于少于60例。另一个更大的研究结果 建议不存在关联；需要其他数据。 非洲 美国人对DDE的接触比白人美国人更大，因此 对非裔美国人的DDE-胸癌协会的检查可能 比较小的研究具有更大的统计能力来检测效果 裸露的人群。 我们建议进行一项病例对照研究，以检验以下假设。 血清中有机氯残基的水平与增加有关 非裔美国妇女乳腺癌的风险。 该研究将是 添加了由国家儿童健康研究所资助的正在进行的研究 和发展。 正在进行的研究，妇女的避孕和 生殖经验（CARE）研究是一项基于人群的多中心 病例对照研究是在35-64岁的五个地区的妇女中进行的 美国，包括洛杉矶县。 对于本研究，我们将 注册非裔美国人参与者在洛杉矶 县。 病例将通过洛杉矶县癌症确定 监视计划（先知癌症注册表）。 通过随机数字拨号。 在受试者完成面试之后 妇女护理研究，将要求她们提供血液标本 目前的研究。 我们将从300名非裔美国人乳腺癌病例和300例中获得血液 对照和测量血清有机氯残基（DDE，PCB，Heptachlor） 环氧化物，氧化甲烷，跨非甲氯，dieldrin，hcb和beta-bhc）和 使用标准方法的总脂质。 血清残留水平将是 与多元乳腺癌的几率有关 无条件的逻辑回归模型。