NEUROPEPTIDERGIC CONTROL OF MATERNAL BEHAVIOR

母体行为的神经肽能控制

• 批准号: 7112801
• 负责人: BENJAMIN C NEPHEW
• 金额: $ 4.88万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-15 至 2008-03-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7112801
• 关键词: aggression; arginine vasopressin; behavioral /social science research tag; endoribonucleases; female; hormone inhibitor; laboratory rat; lactation; maternal behavior; memory; neuroanatomy; neurochemistry; neuroendocrine system; neuropeptides; neuropharmacologic agent; neuropsychology; postdoctoral investigator; postpartum; social behavior

DESCRIPTION (provided by applicant): Three specific aims are proposed to address the overall hypothesis that arginine vasopressin (AVP) has significant roles in the retention of maternal behavior, the expression maternal aggression, and that there are potential connections between central AVP levels and the expression of maternal behavior and aggression. In addition, the potential connection between AVP's effects on maternal behavior and its established role in social recognition will be explored. In Specific Aim 1, we postulate that AVP may play a role in the retention of maternal behavior. In contrast to the wealth of research supporting AVP's role in social recognition and parental behavior in other rodent species, there is a paucity of research focusing on AVP and maternal behavior or aggression in the rat. Specific Aim 2 will attempt to determine if AVP modulates maternal aggression. It has been shown that AVP stimulates aggression in non-lactating rodents, but its role in maternal aggression is uncertain. Specific Aim 3 will investigate AVP anatomy in lactating rodents by examining AVP and AVP mRNA levels in behaviorally relevant nuclei in lactating rats using RIA and RNase protection, and potential correlations between AVP and aggression will be explored.

描述（由申请人提供）：提出了三个特定的目的，以解决精氨酸加压素（AVP）在孕产妇行为的保留，表达孕产妇侵略以及中央AVP水平之间的潜在联系与母体行为和孕妇行为和侵略之间的潜在联系。此外，将探讨AVP对孕产妇行为的影响与其在社会认可中的既定作用之间的潜在联系。在特定目标1中，我们假设AVP可能在孕产妇行为的保留中发挥作用。与支持AVP在其他啮齿动物物种中的社会认识和父母行为中的作用相反，研究重点是大鼠的AVP和孕产妇行为或侵略性。特定目标2将尝试确定AVP是否调节母体侵略。已经表明，AVP刺激非泌乳啮齿动物的侵略性，但其在母体侵略中的作用尚不确定。特定的目标3将通过使用RIA和RNase保护在行为相关的核中检查泌乳啮齿动物的AVP解剖结构，并研究AVP与攻击之间的潜在相关性。