Effects of Early Experience

早期经历的影响

• 批准号: 6970319
• 负责人: CAROL SUE CARTER PORGES
• 金额: $ 32.1万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-25 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6970319
• 关键词: aggression; animal developmental psychology; arginine vasopressin; autoradiography; behavior test; behavioral /social science research tag; blood tests; corticosterone; corticotropin releasing factor; early experience; enzyme linked immunosorbent assay; family structure /dynamics; hormone regulation /control mechanism; immunocytochemistry; longitudinal animal study; neuroendocrine system; neuropeptides; oxytocin; parent offspring interaction; preference; psychological stressor; social behavior; statistics /biometry; vole

DESCRIPTION (provided by applicant): The general goal of this research is to examine developmental influences on social behaviors and the neuroendocrine mechanisms of these influences. Using as a model the prairie vole, we have observed that apparently minor changes in the manner in which families are "manipulated" in early life can have life-long consequences. We propose to study the relationship between early experiences, including the influence of parental stimulation, and the later tendency to show social behaviors including alloparental behavior, the capacity to form a partner preference, the tendency to show same-sex aggression (possibly indicative of mate guarding), as well as reactivity to stressors. We also propose to test the hypothesis that the behavioral changes we have observed reflect modifications in neuropeptides, including central and blood levels of arginine vasopressin (AVP), oxytocin (OT) or corticotropin releasing hormone (CRH), and the steroid hormone, corticosterone (CORT). Receptor autoradiography will be used to examine the effects of early experience on later regional receptor binding for the OT, AVP (Via), and CRH (type 1 and 2). Intergenerational effects of these experiences will be examined as well.

描述（由申请人提供）：这项研究的一般目标是检查对这些影响的社会行为和神经内分泌机制的发展影响。我们已经观察到，作为模型，我们观察到，在早期生活中“操纵”家庭“操纵”的方式显然会带来终身后果。我们建议研究早期经历之间的关系，包括父母刺激的影响，以及后来显示社会行为的趋势，包括同种族行为，形成伴侣偏好的能力，表现出同性侵略的趋势（可能表明伴侣保护）以及对压力因素的反应。我们还建议测试以下假设：我们观察到的行为变化反映了神经肽的修饰，包括精氨酸加压素（AVP）的中枢和血液水平，催产素（OT）或皮质激素释放的激素（CRH），以及类固醇激素，皮质酮（CROT）。受体放射自显影将用于检查早期体验对OT，AVP（VIA）和CRH（类型1和2）的后期区域受体结合的影响。这些经验的代际效应也将进行检查。