Epigenetic Effects of Early Experience

早期经历的表观遗传效应

• 批准号: 7110856
• 负责人: ERICKA M BOONE
• 金额: $ 5.92万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7110856
• 关键词: adrenocorticotropic hormone; animal developmental psychology; arginine vasopressin; behavior test; behavioral /social science research tag; child behavior; child psychology; corticosterone; depression; early experience; epigenetics; fos protein; growth /development; hormone receptor; imaging /visualization /scanning; maternal behavior; mother deprivation; neuroendocrine system; neurogenesis; oxytocin; paternal behavior; postdoctoral investigator; psychosocial separation; stress; time resolved data; vole

DESCRIPTION (provided by applicant): Decades of clinical and basic research have shown a clear relationship between early life experiences and future life events. Research suggests childhood trauma/adverse experiences as leading risk factors for the development of psychopathological disorders including major depression, anxiety, drug abuse, PTSD, etc. Recent studies of early maternal separation effects in rats demonstrate that variation in early maternal care during the neonatal period shape adult social behavior and stress responses in lower mammals. A major goal of these studies is to define times in development (sensitive periods) and strategies for intervening to prevent/reverse/ameliorate neurobiological and behavioral deficits resulting from subtle changes in neonatal maternal-pup interactions. Experiments proposed here are designed to address the following hypotheses: 1) subtle changes in length/timing of early maternal separation (or handling) leads to individual differences in the exhibition of stress and parental behaviors, 2) variations in maternal care resulting from differences in timing of handling (H) will be associated with individual differences in developing neural systems, and 3) the effects of early maternal separation, while long-term, can be effectively changed/altered later in life.

描述（由申请人提供）：数十年的临床和基础研究表明，早期生活经历与未来生活事件之间存在明显的关系。研究表明，儿童创伤/不良经历是发展心理病理疾病的主要危险因素，包括重度抑郁症，焦虑症，药物滥用，PTSD等。最近对大鼠早期产妇分离效应的研究表明，在新生儿期间，孕产妇护理的变化在新生儿期间的早期孕产妇护理形式的成人社会行为和下哺乳动物的压力反应。这些研究的一个主要目的是定义开发时间（敏感时期）和干预策略，以预防/反向/改善神经生物学和行为缺陷，这是由于新生儿母体 - 宠物相互作用的细微变化而导致的。此处提出的实验旨在解决以下假设：1）早期孕产妇分离（或处理）的长度/时机的细微变化会导致压力和父母行为表现出个性化的个体差异，2）孕产妇护理中的变化，导致的疗效时间差异（h）在较晚的差异中与早期的效果相关，而早期的效果则与早期的效果相关，而越长的效果则是效果，并且效果的长度效果是效果，并且效果的效果是效果，并且是3个效果。在生活中。