HORMONES AND BEHAVIORAL DEVELOPMENT

荷尔蒙与行为发展

• 批准号: 6795429
• 负责人: Bruce S Cushing
• 金额: $ 11.64万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-02 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6795429
• 关键词: animal developmental psychology; arginine vasopressin; behavioral /social science research tag; estrogen receptors; ethology; hormone receptor; hormone regulation /control mechanism; laboratory rat; oxytocin; progesterone receptors; sex behavior; species difference; vole

DESCRIPTION (Adapted from applicant's description): The general purpose of this proposal is to examine the behavioral and neurobiological consequences of development exposure to oxytocin (OT). Changes in OT are particularly likely to occur around the time of birth, and the proposed hypothesis is that the consequences of exposure to OT during the neonatal period may be long-lasting, producing functional changes in adulthood. This hypothesis will be examined in the context of female reproductive behaviors, which are particularly sensitive to the effects of OT and steroid hormones and their interactions. Developmental exposure to OT also may affect CNS levels of OT receptors, which could in turn alter sensitivity to OT in adulthood. In addition to behavioral assessments, the investigator proposes using neuroanatomical methods to index, as a function of neonatal manipulations of OT, both OT and OT receptors in adulthood. Developmental exposure to OT may affect adult behavior by influencing steroid sensitivity; this hypothesis will be examined by the measurement of estrogen or progesterone receptors. In addition, the effects of development exposure to OT on arginine vasopressin (AVP) and its receptor (V1a) will be examined; AVP is closely related to OT in both structure and function. Finally, a nonspecific marker of cellular activity (c-Fos) will be used to index the capacity of animals with different developmental histories to respond to adult treatment with estrogen or OT. The behavioral effects of both OT and estrogen can be species specific; for this reason two animal models (prairie voles and rats) have been selected, taking into account the advantages of each for examining the behavioral effects of both OT and steroid hormones and their interactions.

描述（改编自申请人的描述）：一般用途 该提案旨在检查行为和神经生物学后果 发育暴露于催产素（OT）。 OT 的变化特别有可能 发生在出生前后，所提出的假设是 新生儿期暴露于 OT 的后果可能是长期持续的， 成年后产生功能变化。 该假设将被检验 在女性生殖行为方面，尤其是 对 OT 和类固醇激素的影响及其相互作用敏感。 发育过程中暴露于 OT 也可能影响中枢神经系统 OT 受体的水平， 反过来可能会改变成年后对 OT 的敏感性。 除了行为上 评估，研究人员建议使用神经解剖学方法来索引， 作为新生儿对 OT 操作的函数，OT 和 OT 受体均在 成年期。 发育时期接触 OT 可能会通过以下方式影响成人行为： 影响类固醇敏感性；该假设将由 雌激素或孕激素受体的测量。 另外，效果 OT 发育暴露对精氨酸加压素 (AVP) 及其受体的影响 (V1a)将受到审查； AVP 在结构和功能上都与 OT 密切相关。 功能。 最后，细胞活性的非特异性标记物 (c-Fos) 将是 用于索引具有不同发育历史的动物的能力 对成人雌激素或 OT 治疗有反应。 的行为影响 OT 和雌激素都具有物种特异性；由于这个原因，两只动物 选择模型（草原田鼠和大鼠），考虑到 检查 OT 和类固醇的行为影响时各自的优点 激素及其相互作用。

项目成果

Estrogen receptors in the medial amygdala inhibit the expression of male prosocial behavior.

• DOI: 10.1523/jneurosci.1928-08.2008
• 发表时间: 2008-10-08
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Cushing BS;Perry A;Musatov S;Ogawa S;Papademetriou E
• 通讯作者: Papademetriou E

Sex steroids are necessary in the second postnatal week for the expression of male alloparental behavior in prairie voles (Microtus ochragaster).

性类固醇对于草原田鼠（Microtus ochragaster）雄性异亲行为的表达在出生后第二周是必需的。

• DOI: 10.1037/a0016927
• 发表时间: 2009
• 期刊: Behavioral neuroscience
• 影响因子: 1.9
• 作者: Kramer,KristinM;Perry,AdamN;Golbin,Dina;Cushing,BruceS
• 通讯作者: Cushing,BruceS

Estrogen receptor-alpha in the bed nucleus of the stria terminalis regulates social affiliation in male prairie voles (Microtus ochrogaster).

• DOI: 10.1371/journal.pone.0008931
• 发表时间: 2010-01-27
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Lei K;Cushing BS;Musatov S;Ogawa S;Kramer KM
• 通讯作者: Kramer KM

Oxytocin selectively increases ERalpha mRNA in the neonatal hypothalamus and hippocampus of female prairie voles.

催产素选择性地增加雌性草原田鼠的新生儿下丘脑和海马中的 ERα mRNA。

• DOI: 10.1016/j.npep.2006.10.002
• 发表时间: 2007
• 期刊: Neuropeptides
• 影响因子: 2.9
• 作者: Pournajafi-Nazarloo,Hossein;Carr,MichaelS;Papademeteriou,Eros;Schmidt,JenniferV;Cushing,BruceS
• 通讯作者: Cushing,BruceS

Developmental expression of estrogen receptor beta in the brain of prairie voles (Microtus ochrogaster).

• DOI: 10.1002/dev.21367
• 发表时间: 2016-03
• 期刊: Developmental psychobiology
• 影响因子: 2.2
• 作者: S. Ploskonka;J. Eaton;M. S. Carr;Jennifer V. Schmidt;B. Cushing