HORMONES AND BEHAVIORAL DEVELOPMENT

荷尔蒙与行为发展

基本信息

批准号：
6795429
负责人：
Bruce S Cushing
金额：
$ 11.64万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
起止时间：
2000-09-02 至 2006-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6795429
关键词：
animal developmental psychology arginine vasopressin behavioral /social science research tag estrogen receptors ethology hormone receptor hormone regulation /control mechanism laboratory rat oxytocin progesterone receptors sex behavior species difference vole

项目摘要

DESCRIPTION (Adapted from applicant's description): The general purpose of this proposal is to examine the behavioral and neurobiological consequences of development exposure to oxytocin (OT). Changes in OT are particularly likely to occur around the time of birth, and the proposed hypothesis is that the consequences of exposure to OT during the neonatal period may be long-lasting, producing functional changes in adulthood. This hypothesis will be examined in the context of female reproductive behaviors, which are particularly sensitive to the effects of OT and steroid hormones and their interactions. Developmental exposure to OT also may affect CNS levels of OT receptors, which could in turn alter sensitivity to OT in adulthood. In addition to behavioral assessments, the investigator proposes using neuroanatomical methods to index, as a function of neonatal manipulations of OT, both OT and OT receptors in adulthood. Developmental exposure to OT may affect adult behavior by influencing steroid sensitivity; this hypothesis will be examined by the measurement of estrogen or progesterone receptors. In addition, the effects of development exposure to OT on arginine vasopressin (AVP) and its receptor (V1a) will be examined; AVP is closely related to OT in both structure and function. Finally, a nonspecific marker of cellular activity (c-Fos) will be used to index the capacity of animals with different developmental histories to respond to adult treatment with estrogen or OT. The behavioral effects of both OT and estrogen can be species specific; for this reason two animal models (prairie voles and rats) have been selected, taking into account the advantages of each for examining the behavioral effects of both OT and steroid hormones and their interactions.

描述（根据申请人的描述改编）：该提议是研究的行为和神经生物学后果发育暴露于催产素（OT）。 OT的变化特别可能出生时发生，提出的假设是在新生儿期间暴露于OT的后果可能是长期的在成年中产生功能变化。该假设将进行检查在女性生殖行为的背景下，特别是对OT和类固醇激素及其相互作用的影响敏感。发育性接触OT也可能影响OT受体的中枢神经系统水平，而OT受体的水平反过来可能会改变对成年的敏感性。除了行为评估，研究人员建议使用神经解剖学方法进行索引，作为OT的新生儿操纵的函数，OT和OT受体都在成年。发育暴露于OT可能会影响成人行为影响类固醇敏感性；该假设将由雌激素或孕酮受体的测量。另外，效果精氨酸加压素（AVP）及其受体的发育暴露于OT （V1A）将进行检查； AVP在结构和结构上都与OT密切相关功能。最后，细胞活性（C-FOS）的非特异性标记将是用于索引具有不同发展历史的动物的能力用雌激素或OT应对成人治疗。行为影响 OT和雌激素都可以特定于物种。因此，两只动物选择了模型（草原田鼠和大鼠），考虑到每个人都在检查OT和类固醇的行为影响方面的优势激素及其相互作用。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Estrogen receptors in the medial amygdala inhibit the expression of male prosocial behavior.

DOI：
10.1523/jneurosci.1928-08.2008
发表时间：
2008-10-08
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
0
作者：
Cushing BS;Perry A;Musatov S;Ogawa S;Papademetriou E
通讯作者：
Papademetriou E

Sex steroids are necessary in the second postnatal week for the expression of male alloparental behavior in prairie voles (Microtus ochragaster).

性类固醇对于草原田鼠（Microtus ochragaster）雄性异亲行为的表达在出生后第二周是必需的。

DOI：
10.1037/a0016927
发表时间：
2009
期刊：
Behavioral neuroscience
影响因子：
1.9
作者：
Kramer,KristinM;Perry,AdamN;Golbin,Dina;Cushing,BruceS
通讯作者：
Cushing,BruceS

Oxytocin selectively increases ERalpha mRNA in the neonatal hypothalamus and hippocampus of female prairie voles.

催产素选择性地增加雌性草原田鼠的新生儿下丘脑和海马中的 ERα mRNA。

DOI：
10.1016/j.npep.2006.10.002
发表时间：
2007
期刊：
Neuropeptides
影响因子：
2.9
作者：
Pournajafi-Nazarloo,Hossein;Carr,MichaelS;Papademeteriou,Eros;Schmidt,JenniferV;Cushing,BruceS
通讯作者：
Cushing,BruceS

Estrogen receptor-alpha in the bed nucleus of the stria terminalis regulates social affiliation in male prairie voles (Microtus ochrogaster).