Neurobiology of Social Support

社会支持的神经生物学

• 批准号: 7575745
• 负责人: CAROL SUE CARTER PORGES
• 金额: $ 33.86万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2011-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7575745
• 关键词: Adult; Aggressive behavior; Amygdaloid structure; Animal Model; Area; Argipressin; Autistic Disorder; Behavior; Behavioral; Birth; Blood; Brain; Corticosterone; Data; Development; Emotions; Endocrine; Exposure to; Female; Fright; Future; Gender; Goals; Health Benefit; Hormonal Change; Hormones; Individual Differences; Infant; Lactation; Lateral; Measures; Mediating; Mental disorders; Microdialysis; Microtus; Neurobiology; Neurohormones; Neuropeptides; Neurosecretory Systems; Nucleus Accumbens; Oxytocin; Pair Bond; Parenting behavior; Partner in relationship; Pattern; Peptides; Physiological; Physiology; Play; Postpartum Period; Pregnancy; Prevention; Process; Psyche structure; Regulation; Research; Rodent; Role; Schizophrenia; Sex Characteristics; Social Behavior; Social Interaction; Social support; Stimulus; Stress; Structure of terminal stria nuclei of preoptic region; Substance abuse problem; System; Testing; Time; base; behavior measurement; child neglect; depression; experience; hypothalamic-pituitary-adrenal axis; immunocytochemistry; interest; male; neurophysiology; novel; physical conditioning; prairie vole; preference; pup; relating to nervous system; response; sexual dimorphism; social; social attachment; stress management; stressor

DESCRIPTION (provided by applicant): Social engagement, social support and social bonds can have positive health benefits, although the mechanisms for these effects are at present not well understood. We propose here to use the socially-monogamous prairie vole (Microtus ochrogaster) as an animal model to examine mechanisms for socially-induced changes in behavior and physiology. The proposed study postulates a novel mechanism through which even a brief social experience, possibly mediated in part by neuropeptide systems, can impact future behavior and brain function. Preliminary data reveal that exposure to an infant can significantly facilitate pair bonding, can release the brain hormone oxytocin (OT) and inhibit the activity of "stress" hormones from the hypothalamic-pituitary-adrenal axis. Here we propose to study regionally specific neuroendocrine changes that accompany pup exposure, focusing on neural systems, such as the amygdala, that are associated with social behavior and fear, and that are targets for OT, and a related neurohormone, arginine vasopressin (AVP). We also will further investigate the consequences of pup exposure through an analysis of subsequent social behaviors, including sociality to strangers and pair bond formation. Measures will include behavioral and neuroendocrine responses (measured by brain microdialysis, cFos and immunocytochemistry, and blood levels of OT, AVP and corticosterone). We will study both individual differences and gender-specific patterns of behavioral and neuroendocrine responding to pups to examine the hypothesis that these differences may reflect the actions of these hormones, including especially OT in females and AVP in males. Multiple measures focused around a simple paradigm (responses to a pup) allow an analysis of relationships among behavioral and neuroendocrine parameters, including behavior and physiology, which may share common neural substrates. Deficits in social behavior are a feature of several forms of mental illness, including autism, depression and schizophrenia, and may be associated with a vulnerability to substance abuse. The proposed study will contribute to our basic understanding of mammalian social behavior, and especially processes associated with parenting. In addition, these studies may help us understand neuroendocrine mechanisms underlying child neglect or abuse and why these may differ in males and females.

描述（由申请人提供）：社会参与，社会支持和社会纽带可以具有积极的健康益处，尽管目前尚不清楚这些影响的机制。我们在这里建议使用社会兼而有之的草原vole（Microtus ochrogaster）作为动物模型，以检查社会诱发的行为和生理学变化的机制。拟议的研究假设了一种新型机制，即使是简短的社会经验，可能部分是由神经肽系统介导的，也会影响未来的行为和大脑功能。初步数据表明，暴露于婴儿可以显着促进配对，可以释放脑激素催产素（OT），并抑制下丘脑 - 垂体 - 肾上腺肾上腺轴的“应激”激素的活性。在这里，我们建议研究与幼犬暴露的区域特定的神经内分泌变化，重点是与社会行为和恐惧有关的神经系统，例如杏仁核，它们是OT的靶标，以及相关的神经激素，精氨酸加压素（AVP）。我们还将通过分析随后的社会行为，包括对陌生人的社会性和配对纽带形成，进一步研究幼犬暴露的后果。措施将包括行为和神经内分泌反应（通过脑透析，CFO和免疫细胞化学以及OT，AVP和皮质酮的血液水平测量）。我们将研究对幼崽反应的行为和神经内分泌的个体差异和性别特异性的模式，以检查这些差异可能反映了这些激素的作用，包括雌性和雄性中的AVP的作用。围绕简单范式（对幼犬的响应）的多种度量允许分析行为和神经内分泌参数之间的关系，包括行为和生理学，这些参数可能具有共同的神经底物。社会行为的缺陷是几种形式的精神疾病的特征，包括自闭症，抑郁症和精神分裂症，可能与遭受药物滥用的脆弱性有关。拟议的研究将有助于我们对哺乳动物社会行为，尤其是与育儿相关的过程的基本理解。此外，这些研究可能有助于我们理解儿童忽视或虐待的神经内分泌机制，以及为什么这些机制在男性和女性中可能会有所不同。