Central Vasopressin and Maternal Behavior

中枢加压素和母亲行为

• 批准号: 7739025
• 负责人: BENJAMIN C NEPHEW
• 金额: $ 8.84万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-15 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7739025
• 关键词: Acute; Adrenal Cortex Hormones; Affect; Aggressive behavior; Anxiety; Argipressin; Autoradiography; Behavior; Behavior Control; Behavior Disorders; Behavioral; Brain region; Child; Child health care; Chronic; Chronic stress; Computer Retrieval of Information on Scientific Projects Database; Data; Databases; Development; Disease; Drops; Endocrine; Ensure; Etiology; Exposure to; Female; Focus Groups; Functional Magnetic Resonance Imaging; Goals; Health; Health behavior; Hormones; Human; Image; In Situ Hybridization; Instruction; Investigation; Lactation; Life; Link; Maternal Behavior; Mediating; Messenger RNA; Methods; Mission; Molecular; Mood Disorders; Mothers; National Institute of Child Health and Human Development; Neurohormones; Neurosciences; Neurosecretory Systems; Operative Surgical Procedures; Oxytocin; Oxytocin Receptor; Peptides; Peripheral; Personal Satisfaction; Persons; Physiological; Physiology; Postpartum Depression; Postpartum Period; Productivity; Protocols documentation; Rattus; Rehabilitation therapy; Reporting; Reproductive Process; Research; Research Personnel; Risk Factors; Role; Stress; System; Techniques; Testing; Training; United States National Institutes of Health; Vasopressins; Woman; acute stress; base; career; depression; disability; indexing; mRNA Differential Displays; mRNA Expression; maternal aggression; molecular imaging; offspring; parity; programs; public health relevance; pup; relating to nervous system; response; social; social stress; stressor

DESCRIPTION (provided by applicant): The mission of the NICHD is to ensure that every person is bom healthy and wanted, that women suffer no harmful effects from reproductive processes, and that all children have the chance to achieve their full potential for healthy and productive lives, free from disease or disability, and to ensure the health, productivity, independence, and well-being of all people through optimal rehabilitation. Postpartum anxiety and depression- associated disorders can have negative effects on the health of both mother and offspring through effects on maternal behavior, and little is known about the etiology of these disorders. Although chronic stress is a significant risk factor for depression, it is unknown how chronic stress during lactation affects maternal behavior. Recent molecular studies indicate that the neurohormones arginine vasopressin (AVP), oxytocin (OXT), and corticosteroid releasing hormone (CRH) may be involved in the modulation of maternal behavior in lactating rats. It is h3T) 0thesized that the central AVP system may be a potential target for the treatment of postpartum behavioral disorders, as central manipulations of AVP alter behavior. The overall objective of the current protocol is to investigate the role of AVP in postpartum maternal behavior and aggression, and the effects of social stress on this system. The specific aims of the current proposal are to characterize the roles of central AVP, OXT, and CRH in the control of maternal behavior and maternal aggression, investigate the effects of chronic social stressors on these behaviors and central AVP, and investigate a potential AVP-mediated mechanism for the effects of chronic social stress on maternal behavior. These aims will be pursued using behavioral, endocrine, and molecular methods to quantify the effects of chronic social stressors, molecular and imaging (fMRI) techniques to identify the neural regions implicated in the acute and chronic control of maternal behavior, and stereotaxic surgical techniques to manipulate central AVP activity. The overall goal is to gain valuable training in behavioral neuroscience techniques and study the neuropeptidergic control of behavior. The long term career goal is to develop new targets and treatments for behavioral disorders of mothers. PUBLIC HEALTH RELEVANCE (See instructions): Although it is clear that the behavior of the mother affects the behavior and health of her children, very few studies have been directed at determining the causes of postpartum behavioral disorders. This application will help to ensure the health of mothers and their children by investigating potential mechanisms for the control of maternal behavior and causes for postpartum behavioral disorders.

描述（由申请人提供）：NICHD 的使命是确保每个人出生时都是健康和想要的，妇女不会受到生殖过程的有害影响，并且所有儿童都有机会充分发挥其健康和生产的潜力生命，免受疾病或残疾的困扰，并通过最佳康复确保所有人的健康、生产力、独立性和福祉。产后焦虑和抑郁相关疾病可能通过影响母亲行为而对母亲和后代的健康产生负面影响，但人们对这些疾病的病因知之甚少。尽管慢性压力是抑郁症的一个重要危险因素，但目前尚不清楚哺乳期间的慢性压力如何影响母亲的行为。最近的分子研究表明，神经激素精氨酸加压素（AVP）、催产素（OXT）和皮质类固醇释放激素（CRH）可能参与哺乳大鼠母性行为的调节。据推测，中央 AVP 系统可能是治疗产后行为障碍的潜在目标，因为 AVP 的中央操作会改变行为。当前协议的总体目标是调查 AVP 在产后母亲行为和攻击行为中的作用，以及社会压力对该系统的影响。当前提案的具体目标是描述中枢 AVP、OXT 和 CRH 在控制母亲行为和母亲攻击性中的作用，研究慢性社会压力源对这些行为和中枢 AVP 的影响，并研究潜在的 AVP-慢性社会压力对母亲行为影响的中介机制。这些目标将通过使用行为、内分泌和分子方法来量化慢性社会压力源的影响，使用分子和成像（fMRI）技术来识别与急性和慢性控制产妇行为有关的神经区域，并使用立体定位手术技术来实现操纵中枢 AVP 活动。总体目标是获得行为神经科学技术的宝贵培训并研究行为的神经肽控制。长期职业目标是开发母亲行为障碍的新目标和治疗方法。 公众健康相关性（参见说明）：虽然很明显母亲的行为会影响孩子的行为和健康，但很少有研究直接确定产后行为障碍的原因。该应用程序将通过研究控制孕产妇行为的潜在机制和产后行为障碍的原因，有助于确保母亲及其孩子的健康。