Vasopressin and Maternal Behavior

加压素和母亲行为

基本信息

批准号：
8601537
负责人：
BENJAMIN C NEPHEW
金额：
$ 24.2万
依托单位：
TUFTS UNIVERSITY BOSTON
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-15 至 2014-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8601537
关键词：
Acute Adrenal Cortex Hormones Affect Aggressive behavior Anxiety Argipressin Autoradiography Behavior Behavior Control Behavior Disorders Behavioral Brain region Child Child health care Chronic Chronic stress Computer Retrieval of Information on Scientific Projects Database Data Databases Development Disease Drops Endocrine Ensure Etiology Exposure to Female Focus Groups Functional Magnetic Resonance Imaging Goals Health Health behavior Hormones Human Image In Situ Hybridization Investigation Lactation Link Maternal Behavior Mediating Mental Depression Messenger RNA Methods Mission Molecular Mood Disorders Mothers National Institute of Child Health and Human Development Neurohormones Neurosciences Neurosecretory Systems Operative Surgical Procedures Oxytocin Oxytocin Receptor Peptides Peripheral Personal Satisfaction Persons Physiological Physiology Postpartum Depression Postpartum Period Productivity Protocols documentation Rattus Rehabilitation therapy Reporting Reproductive Process Research Risk Factors Role Stress Structure System Techniques Testing Training United States National Institutes of Health Vasopressins Woman acute stress base career disability indexing mRNA Differential Displays mRNA Expression maternal aggression molecular imaging offspring parity pup relating to nervous system release factor research study response social social stress stressor

项目摘要

The mission ofthe NICHD is to ensure that every person is born healthy and wanted, that women suffer no harmful effects from reproductive processes, and that ail children have the chance to achieve their full potential for healthy and productive lives, free from disease or disability, and to ensure the health, productivity, independence, and well-being of all people through optimal rehabilitation. Postpartum anxiety and depression-associated disorders can have negative effects on the health of both mother and offspring through effects on matemal behavior, and little is known about the etiology of these disorders. Although chronic stress is a significant risk factor for depression, it is unknown how chronic stress during lactation affects maternal behavior. Recent molecular studies indicate that the neurohormones arginine vasopressin (AVP), oxytocin (OXT), and corticosteroid releasing hormone (CRH) may be involved in the modulation of maternal behavior in lactating rats. It is hypothesized that the central AVP system may be a potential target for the treatment of postpartum behavioral disorders, as central manipulations of AVP alter behavior. The overall objective of the current protocol is to investigate the role of AVP in postpartum maternal behavior and aggression, and the effects of social stress on this system. The specific aims ofthe current proposal are to characterize the roles of central AVP, OXT, and CRH in the control of maternal behavior and maternal aggression, investigate the effects of chronic social stressors on these behaviors and central AVP, and investigate a potential AVP-mediated mechanism forthe effects of chronic social stress on maternal behavior. These aims will be pursued using behavioral, endocrine, physiological and molecular methods to quantify the effects of chronic social stressors, molecular and imaging (fMRI) techniques to identify the neural regions implicated in the acute and chronic control of maternal behavior, and stereotaxic surgical techniques to manipulate central AVP activity. The overal goal is to gain valuable training in behavioral) neuroscience techniques and study the neuropeptidergic control of behavior. The long term career goal is to develop new targets and treatments for behavioral disorders of mothers.

NICHD 的使命是确保每个人出生时都健康且想要，妇女不遭受任何痛苦生殖过程的有害影响，以及所有儿童都有机会实现其充分发展健康和富有成效的生活的潜力，没有疾病或残疾，并确保健康，通过最佳康复，提高所有人的生产力、独立性和福祉。产后焦虑抑郁症相关疾病会对母亲和后代的健康产生负面影响通过对母亲行为的影响，人们对这些疾病的病因知之甚少。虽然慢性压力是抑郁症的一个重要危险因素，目前尚不清楚哺乳期间的慢性压力如何影响母亲的行为。最近的分子研究表明，神经激素精氨酸加压素 (AVP)、催产素 (OXT) 和皮质类固醇释放激素 (CRH) 可能参与调节哺乳期大鼠的母性行为。假设中央 AVP 系统可能是潜在目标用于治疗产后行为障碍，因为 AVP 的中央操作会改变行为。这当前协议的总体目标是调查 AVP 在产后母亲行为中的作用和攻击性以及社会压力对该系统的影响。当前提案的具体目标是描述中枢AVP、OXT和CRH在母性行为和母性控制中的作用攻击性，调查慢性社会压力源对这些行为和中枢 AVP 的影响，以及研究慢性社会压力对母亲影响的潜在 AVP 介导机制行为。这些目标将通过行为、内分泌、生理和分子方法来实现量化慢性社会压力源、分子和成像 (fMRI) 技术的影响，以确定与母亲行为的急性和慢性控制有关的神经区域以及立体定位手术操纵中枢 AVP 活动的技术。总体目标是获得行为方面的宝贵培训）神经科学技术并研究神经肽能控制行为。长期职业目标是制定母亲行为障碍的新目标和治疗方法。