NEUROPEPTIDERGIC CONTROL OF MATERNAL BEHAVIOR

母体行为的神经肽能控制

• 批准号: 7287304
• 负责人: BENJAMIN C NEPHEW
• 金额: $ 5.04万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-15 至 2008-03-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7287304
• 关键词: Address; Aggressive behavior; Anatomy; Arginine; Argipressin; Behavior; Birth; Brain region; Cell Nucleus; Data; Endoribonucleases; Fellowship; Individual; Investigation; Lactation; Lateral; Maternal Behavior; Messenger RNA; Modeling; Neural Pathways; Pancreatic ribonuclease; Play; Postpartum Period; Pregnancy; Radioimmunoassay; Rattus; Relative (related person); Research; Research Support; Ribonucleases; Rodent; Role; Social Behavior; Vasopressins; base; experience; maternal aggression; relating to nervous system; social

DESCRIPTION (provided by applicant): Three specific aims are proposed to address the overall hypothesis that arginine vasopressin (AVP) has significant roles in the retention of maternal behavior, the expression maternal aggression, and that there are potential connections between central AVP levels and the expression of maternal behavior and aggression. In addition, the potential connection between AVP's effects on maternal behavior and its established role in social recognition will be explored. In Specific Aim 1, we postulate that AVP may play a role in the retention of maternal behavior. In contrast to the wealth of research supporting AVP's role in social recognition and parental behavior in other rodent species, there is a paucity of research focusing on AVP and maternal behavior or aggression in the rat. Specific Aim 2 will attempt to determine if AVP modulates maternal aggression. It has been shown that AVP stimulates aggression in non-lactating rodents, but its role in maternal aggression is uncertain. Specific Aim 3 will investigate AVP anatomy in lactating rodents by examining AVP and AVP mRNA levels in behaviorally relevant nuclei in lactating rats using RIA and RNase protection, and potential correlations between AVP and aggression will be explored.

描述（由申请人提供）：提出了三个具体目标来解决以下总体假设：精氨酸加压素（AVP）在保留母性行为、表达母性攻击性方面具有重要作用，并且中枢 AVP 水平与母体攻击性之间存在潜在联系。母亲行为和攻击性的表达。此外，还将探讨 AVP 对母亲行为的影响与其在社会认可中的既定作用之间的潜在联系。在具体目标 1 中，我们假设 AVP 可能在母亲行为的保留中发挥作用。与支持 AVP 在其他啮齿类动物的社会认可和亲代行为中的作用的大量研究相比，很少有研究关注 AVP 和大鼠的母性行为或攻击性。具体目标 2 将尝试确定 AVP 是否调节母亲的攻击性。研究表明，AVP 会刺激非哺乳期啮齿动物的攻击性，但其在母性攻击性中的作用尚不确定。具体目标 3 将通过使用 RIA 和 RNase 保护检查哺乳大鼠行为相关核中的 AVP 和 AVP mRNA 水平来研究哺乳啮齿动物的 AVP 解剖结构，并将探讨 AVP 与攻击性之间的潜在相关性。