Social Information Processing in the Vomeronasal System during Active Behavior

主动行为期间犁鼻系统的社会信息处理

基本信息

批准号：
10751849
负责人：
Kevin James Monk
金额：
$ 7.18万
依托单位：
BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-05-01 至 2026-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10751849
关键词：
Accessory Olfactory Bulbs Address Affect Afferent Neurons Age Aggressive behavior Amygdaloid structure Anatomy Animals Area Behavior Behavioral Brain Complex Comprehension Coupled Detection Electrophysiology (science)Environment Event Female Head Human Image Individual Investigation Label Life Limbic System Medial Memory Microscope Mus Nervous System Neurons Output Partner in relationship Pathway interactions Pattern Peripheral Pheromone Physiological Population Process Recording of previous events Sampling Sensory Sexual Partners Shapes Signal Transduction Site Social Behavior Social Controls Social Interaction Structure Structure of terminal stria nuclei of preoptic region Support System System Technology Training Viral Vomeronasal Systems awake behavior change experience experimental study feature detection flexibility genetic manipulation information processing innovation male mitral cell nerve supply network architecture neural neuromechanism olfactory bulb glomeruli response sensory input sensory mechanism sex social social learning stimulus processing transmission process

Accessory Olfactory Bulbs Address Affect Afferent Neurons Age Aggressive behavior Amygdaloid structure Anatomy Animals Area Behavior Behavioral Brain Complex Comprehension Coupled Detection Electrophysiology (science)Environment Event Female Head Human Image Individual Investigation Label Life Limbic System Medial Memory Microscope Mus Nervous System Neurons Output Partner in relationship Pathway interactions Pattern Peripheral Pheromone Physiological Population Process Recording of previous events Sampling Sensory Sexual Partners Shapes Signal Transduction Site Social Behavior Social Controls Social Interaction Structure Structure of terminal stria nuclei of preoptic region Support System System Technology Training Viral Vomeronasal Systems awake behavior change experience experimental study feature detection flexibility genetic manipulation information processing innovation male mitral cell nerve supply network architecture neural neuromechanism olfactory bulb glomeruli response sensory input sensory mechanism sex social social learning stimulus processing transmission process

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项目摘要

Project Summary/Abstract Animals combine sensory information and prior experiences to select and adapt behavior. How the brain supports this ability is unknown, and this question is advantageously addressed through investigations of mouse social behavior. In mice, social behaviors are strongly coupled to the detection of well-defined chemosignals (e.g., pheromones), are stereotypical across individuals, and are robustly modulated by an animal’s history. These features provide an excellent framework to define behaviorally-relevant brain areas and investigate the underlying neural mechanisms of sensory-guided, flexible behavior. Indeed, previous studies implicate the accessory olfactory bulb (AOB) in regulating social behaviors, but technical limitations have precluded the ability to record activity during naturalistic interactions among freely-moving conspecific partners. Thus, our understanding of how social behavior shapes ongoing neural activity and how this activity, in turn, guides social behavior during active behavior remains limited. This proposal incorporates several innovative experimental strategies and technological advances to deepen our understanding of the neural dynamics and network architectures that support social behavior. Specifically, I will first use head-mounted miniature microscopes (“miniscopes”) to determine how social information is represented within the AOB of freely-moving mice during prolonged interactions as animals actively engage with a range of conspecific partners and with unique chemosignals. Next, I propose to establish the relationship between AOB activity and intermale aggression. First, through targeted ex vivo recordings and bidirectional chemogenetic manipulations, I will establish the relationship between functionally defined AOB neurons and aggression levels. Next, I will determine how AOB sensory responses are affected by mating; a salient life event that promotes AOB plasticity and increases aggression in male mice. Together, I will establish how neural activity within the AOB adapts in support of flexible behavior. Finally, I propose to define how social information is distributed to downstream, behaviorally-relevant limbic area targets. I will perform multi-site retrograde labeling and pathway-specific manipulations to define how the AOB innervates downstream targets and the behavioral relevance of these pathways. Together, these experiments will provide fundamental information of how the brain represents, modifies, and distributes social information in support of flexible behavior. Moreover, these results will further establish the AOB and related structures as a powerful framework to explore the neural underpinnings of complex behavior.

项目摘要/摘要动物结合感官信息和先前的经验，以选择和适应行为。大脑如何支持此能力是未知的，并且通过对鼠标的调查来有利地解决了这个问题社会行为。在小鼠中，社会行为与检测明确定义的化学信号的检测强烈耦合（例如，信息素）是各个个体的刻板印象，并且受动物历史的牢固调节。这些功能提供了一个很好的框架，可以定义与行为相关的大脑区域并研究感官引导，柔性行为的基本神经机制。确实，以前的研究暗示了配件嗅球（AOB）在调节社会行为方面，但技术局限性排除了能力记录自由移动概念伙伴之间自然互动期间的活动。那，我们的了解社会行为如何塑造正在进行的神经活动以及这种活动如何指导社会主动行为期间的行为仍然有限。该建议包含了几个创新的实验策略和技术进步，加深我们对神经动态和网络的理解支持社会行为的体系结构。具体而言，我将首先使用头部安装的微型显微镜（“ Miniscopes”）确定在自由移动小鼠的AOB中如何表示社会信息随着动物的积极与一系列概念伙伴的积极互动，并具有独特的互动化学信号。接下来，我建议建立AOB活动与碎间侵略性之间的关系。第一的，通过靶向的离体记录和双向化学发生操作，我将建立关系在功能定义的AOB神经元和攻击水平之间。接下来，我将确定AOB感觉如何响应受交配的影响；一个显着的生活事件，可提高AOB的可塑性并提高积极性雄性老鼠。我将共同确定AOB内的神经活动如何适应灵活行为。最后，我建议定义如何将社会信息分配给下游，行为与行为相关的边缘区域目标。我将执行多站点的逆行标签和特定途径的操作，以定义AOB如何支配下游目标和这些途径的行为相关性。在一起，这些实验将提供有关大脑如何代表，修改和分发社会信息的基本信息支持灵活的行为。此外，这些结果将进一步建立AOB和相关结构探索复杂行为的神经基础的强大框架。