Vasopressin and Maternal Behavior

加压素和母亲行为

• 批准号: 8391246
• 负责人: BENJAMIN C NEPHEW
• 金额: $ 23.07万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-15 至 2014-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8391246
• 关键词: Acute; Adrenal Cortex Hormones; Affect; Aggressive behavior; Anxiety; Argipressin; Autoradiography; Behavior; Behavior Control; Behavior Disorders; Behavioral; Brain region; Child; Child health care; Chronic; Chronic stress; Computer Retrieval of Information on Scientific Projects Database; Data; Databases; Development; Disease; Drops; Endocrine; Ensure; Etiology; Exposure to; Female; Focus Groups; Functional Magnetic Resonance Imaging; Goals; Health; Health behavior; Hormones; Human; Image; In Situ Hybridization; Investigation; Lactation; Link; Maternal Behavior; Mediating; Mental Depression; Messenger RNA; Methods; Mission; Molecular; Mood Disorders; Mothers; National Institute of Child Health and Human Development; Neurohormones; Neurosciences; Neurosecretory Systems; Operative Surgical Procedures; Oxytocin; Oxytocin Receptor; Peptides; Peripheral; Personal Satisfaction; Persons; Physiological; Physiology; Postpartum Depression; Postpartum Period; Productivity; Protocols documentation; Rattus; Rehabilitation therapy; Reporting; Reproductive Process; Research; Risk Factors; Role; Stress; Structure; System; Techniques; Testing; Training; United States National Institutes of Health; Vasopressins; Woman; acute stress; base; career; disability; indexing; mRNA Differential Displays; mRNA Expression; maternal aggression; molecular imaging; offspring; parity; pup; relating to nervous system; release factor; research study; response; social; social stress; stressor

The mission ofthe NICHD is to ensure that every person is born healthy and wanted, that women suffer no harmful effects from reproductive processes, and that ail children have the chance to achieve their full potential for healthy and productive lives, free from disease or disability, and to ensure the health, productivity, independence, and well-being of all people through optimal rehabilitation. Postpartum anxiety and depression-associated disorders can have negative effects on the health of both mother and offspring through effects on matemal behavior, and little is known about the etiology of these disorders. Although chronic stress is a significant risk factor for depression, it is unknown how chronic stress during lactation affects maternal behavior. Recent molecular studies indicate that the neurohormones arginine vasopressin (AVP), oxytocin (OXT), and corticosteroid releasing hormone (CRH) may be involved in the modulation of maternal behavior in lactating rats. It is hypothesized that the central AVP system may be a potential target for the treatment of postpartum behavioral disorders, as central manipulations of AVP alter behavior. The overall objective of the current protocol is to investigate the role of AVP in postpartum maternal behavior and aggression, and the effects of social stress on this system. The specific aims ofthe current proposal are to characterize the roles of central AVP, OXT, and CRH in the control of maternal behavior and maternal aggression, investigate the effects of chronic social stressors on these behaviors and central AVP, and investigate a potential AVP-mediated mechanism forthe effects of chronic social stress on maternal behavior. These aims will be pursued using behavioral, endocrine, physiological and molecular methods to quantify the effects of chronic social stressors, molecular and imaging (fMRI) techniques to identify the neural regions implicated in the acute and chronic control of maternal behavior, and stereotaxic surgical techniques to manipulate central AVP activity. The overal goal is to gain valuable training in behavioral) neuroscience techniques and study the neuropeptidergic control of behavior. The long term career goal is to develop new targets and treatments for behavioral disorders of mothers.

NICHD 的使命是确保每个人出生时都健康且想要，妇女不遭受任何痛苦 生殖过程的有害影响，以及所有儿童都有机会实现其充分发展 健康和富有成效的生活的潜力，没有疾病或残疾，并确保健康， 通过最佳康复，提高所有人的生产力、独立性和福祉。产后焦虑 抑郁症相关疾病会对母亲和后代的健康产生负面影响 通过对母亲行为的影响，人们对这些疾病的病因知之甚少。虽然 慢性压力是抑郁症的一个重要危险因素，目前尚不清楚哺乳期间的慢性压力如何 影响母亲的行为。最近的分子研究表明，神经激素精氨酸加压素 (AVP)、催产素 (OXT) 和皮质类固醇释放激素 (CRH) 可能参与调节 哺乳期大鼠的母性行为。假设中央 AVP 系统可能是潜在目标 用于治疗产后行为障碍，因为 AVP 的中央操作会改变行为。这 当前协议的总体目标是调查 AVP 在产后母亲行为中的作用和 攻击性以及社会压力对该系统的影响。当前提案的具体目标是 描述中枢AVP、OXT和CRH在母性行为和母性控制中的作用 攻击性，调查慢性社会压力源对这些行为和中枢 AVP 的影响，以及 研究慢性社会压力对母亲影响的潜在 AVP 介导机制 行为。这些目标将通过行为、内分泌、生理和分子方法来实现 量化慢性社会压力源、分子和成像 (fMRI) 技术的影响，以确定 与母亲行为的急性和慢性控制有关的神经区域以及立体定位手术 操纵中枢 AVP 活动的技术。总体目标是获得行为方面的宝贵培训） 神经科学技术并研究神经肽能控制行为。长期职业目标是 制定母亲行为障碍的新目标和治疗方法。