Melanoma detection by optical spectroscopy

通过光谱检测黑色素瘤

• 批准号: 7117638
• 负责人: Lihong Wang
• 金额: $ 37.45万
• 依托单位: TEXAS ENGINEERING EXPERIMENT STATION
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至 2006-08-04
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7117638
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; biopsy; cancer information system; clinical biomedical equipment; clinical research; computer assisted diagnosis; computer system design /evaluation; fiber optics; hemoglobin; human subject; melanoma; morphometry; neoplasm /cancer classification /staging; neoplasm /cancer diagnosis; noninvasive diagnosis; phantom model; portable biomedical equipment; rapid diagnosis; reflection spectrometry; time resolved data

DESCRIPTION (provided by applicant): The goal of the proposed research is to develop, test, and validate a preclinical non-invasive optical instrument, based on spectroscopic Oblique Incidence Reflectometry (OIR), for the rapid diagnosis of pre-cancerous and invasive cancerous skin lesions. The underlying hypothesis, which is well supported by our strong preliminary clinical studies, is that quantitative, spatially resolved, optical-spectral (spatio-spectral) images of skin lesions can provide the dermatologist with clinically valuable diagnostic information to supplement his/her clinical judgment about the need for further diagnostic procedures and/or treatments. OIR intentionally breaks the symmetry of diffuse reflectance that exists in its normal-incidence counterpart and, as a result, provides more robust information about the interrogated tissue volume [Wang et al, US Patent, 5,630,423 (1997)]. A preliminary clinical study of 102 skin lesions using a handheld fiber-optic probe showed that the OIR spectroscopic system differentiated cancerous/pre-cancerous skin lesions from benign lesions with better than 95% accuracy. The applicants have identified the key diagnostic physiological parameters to be (1) the oxygen saturation of hemoglobin, (2) the concentration of total hemoglobin, and (3) the cell-nuclear size. The engineering goal of this proposal is to improve the prototype OIR system to measure skin lesions in real-time and process the data optimally for accurate lesion classification. The mechanistic goal is to identify and quantify the tissue and cellular factors that are responsible for the diagnostic optical features. The clinical goal is to provide accurate, objective, and real-time diagnoses for benign, pre-cancerous, and malignant lesions that are difficult to diagnose clinically. The ultimate societal impact is to improve patient care, save lives, and reduce health care costs. The Specific Aims are listed as follows. 1. To improve instrumentation. 2. To establish a statistically significant database. 3. To develop and validate a diagnostic algorithm. 4. To identify the pathophysiologic parameters responsible for the diagnostic optical features.

描述（由申请人提供）： 拟议研究的目标是开发、测试和验证一种基于光谱斜入射反射计（OIR）的临床前非侵入性光学仪器，用于快速诊断癌前和侵袭性癌性皮肤病变。我们强有力的初步临床研究充分支持了基本假设，即皮肤病变的定量、空间分辨、光学光谱（空间光谱）图像可以为皮肤科医生提供有临床价值的诊断信息，以补充他/她的临床判断关于进一步诊断程序和/或治疗的需要。 OIR有意打破了其正常入射对应物中存在的漫反射的对称性，因此提供了有关被询问组织体积的更可靠的信息[Wang等人，美国专利，5,630,423(1997)]。使用手持式光纤探头对 102 个皮肤病变进行的初步临床研究表明，OIR 光谱系统区分癌性/癌前皮肤病变和良性病变的准确度超过 95%。申请人已确定关键的诊断生理参数是(1)血红蛋白的氧饱和度，(2)总血红蛋白的浓度，以及(3)细胞核大小。该提案的工程目标是改进原型 OIR 系统，以实时测量皮肤病变并优化数据处理以实现准确的病变分类。机械目标是识别和量化负责诊断光学特征的组织和细胞因素。临床目标是对临床难以诊断的良性、癌前期和恶性病变提供准确、客观、实时的诊断。最终的社会影响是改善患者护理、拯救生命并降低医疗保健成本。具体目标如下。 1.改进仪器仪表。 2.建立具有统计意义的数据库。 3. 开发并验证诊断算法。 4. 确定负责诊断光学特征的病理生理参数。