High-speed panoramic 3D photoacoustic computed tomography of the breast

乳房高速全景 3D 光声计算机断层扫描

基本信息

批准号：
9753180
负责人：
Lihong Wang
金额：
$ 80.2万
依托单位：
CALIFORNIA INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-01 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9753180
关键词：
3-Dimensional Acoustics Benign Biopsy Blood Vessels Breast Breast biopsy Clinical Contrast Media Detection Development Diagnosis Diagnostic Elasticity Gold Hemoglobin Hemorrhage Image Imaging technology Ionizing radiation Lasers Lead Lesion Light Malignant - descriptor Mammary Gland Parenchyma Mammographic screening Mammography Methods Modeling Morphologic artifacts Motion Operative Surgical Procedures Optics Oxygen Pain Pathology Patients Penetration Resolution Roentgen Rays Scanning Shapes Speed Stress System Systemic Therapy Testing Time Tissues Tumor Volume Ultrasonography X-Ray Computed Tomography attenuation breast cancer diagnosis breast imaging breast lesion clinically significant cost diffuse optical tomography disease diagnosis elastography follow-up imager imaging system in vivo innovation public health relevance response screening side effect soft tissue spatiotemporal temporal measurement tomosynthesis tool

项目摘要

ABSTRACT (30 Lines Max) Objective: Develop two innovative high-speed 3D breast photoacoustic computed tomography (PACT) systems to diagnose benign, atypical, and malignant lesions — leading to a more streamlined and accurate workup that reduces unnecessary follow-up imaging and benign breast biopsies. Clinical significance: Abnormal findings detected by screening mammography lead to workups including additional imaging, usually in the form of extra mammogram views, tomosynthesis, and/or ultrasound, and possibility of breast biopsy. Biopsies have considerable side effects such as pain and bleeding, and are unnecessary in the majority (60 – 70%) of cases because of the high false-positive rate of mammography. The side effects, costs, and delays of the workups cause considerable stress to patients. PACT combines the functional optical contrast of diffuse optical tomography and the high spatial resolution of ultrasonography without speckle artifacts. The attenuation coefficient of near-IR light in breast tissue is only twice that of mammographic x-ray—enabling adequate optical penetration, but light has far higher soft-tissue contrast than x-ray. With rich functional contrast at high spatial and temporal resolutions and without using ionizing radiation or exogenous contrast agents, 3D breast PACT has the potential to reduce unnecessary benign breast biopsies by serving as a diagnostic tool adjunct to mammography. Possible long-term breast imaging applications include not only diagnosis, but also screening, assessment of response to pre-operative systemic therapy, and definitive surgical planning. Challenges: Numerous innovations are required to develop a PACT imaging system effective for clinical breast imaging. Previous PACT breast imagers possess significant limitations, including suboptimal light delivery, limited detection view, non-isotropic spatial resolution, and long scanning times. There remains an imperative need for more advanced PACT breast imaging technologies. Solutions: Encouraged by the preliminary deep and clear in vivo breast images acquired by our newly developed PACT system, we propose further innovations for 3D functional breast imaging to overcome the above-mentioned limitations. Aim 1: To develop a single-breath-hold 3D breast imaging system with nearly isotropic 3D resolutions and dual-wavelength contrasts (Model I). Aim 2: To develop a snapshot 3D breast PACT system (Model II) using the concept of acoustic ergodicity. It can reach the ultimate imaging speed (single laser shot), desirable for 3D high-resolution functional and dynamic imaging without motion artifacts. Both systems can perform elastography. Contrasts to be imaged include vascularity, concentration and oxygen saturation of hemoglobin, elasticity, and tumor volume and shape. Aim 3: To test PACT for the diagnosis of benign, atypical, and malignant breast lesions by comparing with the gold standard of tissue pathology.

摘要（最多 30 行）目标：开发两种创新型高速 3D 乳腺光声计算机断层扫描 (PACT) 诊断良性、非典型和恶性病变的系统——从而使诊断更加简化和准确减少不必要的后续成像和良性乳腺活检的检查。临床意义：通过筛查乳房X光检查发现的异常结果需要进行检查，包括额外的成像，通常以额外的乳房X光检查、断层合成和/或超声波的形式，以及乳房活检的可能性有相当大的副作用，例如疼痛和出血。由于乳房X光检查的假阳性率很高，因此在大多数情况下（60-70%）是不必要的。副作用、费用和检查延误给患者带来了相当大的压力。漫射光学断层扫描的功能光学对比度和超声检查的高空间分辨率无散斑伪影。近红外光在乳腺组织中的衰减系数仅为其两倍。乳腺 X 射线 — 具有足够的光学穿透力，但光的软组织对比度远高于 X 射线。在高空间和时间分辨率下具有丰富的功能对比度，且无需使用电离辐射或外源性造影剂，3D 乳房 PACT 有可能减少不必要的良性乳房活检作为乳房X光检查的辅助诊断工具。应用不仅包括诊断，还包括筛查、术前系统反应评估治疗和明确的手术计划。挑战：开发适用于临床的 PACT 成像系统需要大量创新以前的 PACT 乳房成像仪具有显着的局限性，包括光线欠佳。传输、有限的检测视野、非各向同性的空间分辨率和长扫描时间。迫切需要更先进的 PACT 乳腺成像技术。解决方案：受到我们新近获得的初步深入且清晰的体内乳腺图像的鼓舞开发了 PACT 系统，我们提出了 3D 功能性乳腺成像的进一步创新，以克服目标 1：开发一种单屏气 3D 乳腺成像系统。各向同性 3D 分辨率和双波长对比度（模型 I）：开发快照 3D 乳房。 PACT系统（Model II）利用声学遍历性的概念，可以达到极限的成像速度。（单次激光拍摄），非常适合 3D 高分辨率功能和动态成像，无运动伪影。两种系统都可以进行弹性成像，成像对比包括血管分布、浓度和氧气。目标 3：测试 PACT 来诊断肿瘤。通过与组织病理学金标准进行比较来确定良性、非典型和恶性乳腺病变。