A Neural Study of the Maturational Shift in Emotion Regulation in Healthy Aging and Depression

健康老龄化和抑郁症中情绪调节成熟转变的神经研究

• 批准号: 9979114
• 负责人: Lihong Wang
• 金额: $ 20.5万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-01 至 2022-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9979114
• 关键词: Adult; Age; Aging; Anterior; Antidepressive Agents; Arousal; Attention; Behavioral; Behavioral Mechanisms; Brain region; Categories; Cognition; Cognitive; Depressed mood; Development; Diagnosis; Dorsal; Elderly; Emotional; Emotions; Factor Analysis; Failure; Foundations; Functional Magnetic Resonance Imaging; Future; Heterogeneity; Impaired cognition; Individual; Intervention; Life; Major Depressive Disorder; Mental Depression; Moods; Patients; Pattern; Pharmaceutical Preparations; Prefrontal Cortex; Prevention; Preventive Intervention; Questionnaires; Recording of previous events; Relapse; Risk; Route; Sex Differences; Stimulus; Testing; Well in self; White Matter Hyperintensity; age group; age related; behavior test; brain volume; causal model; cerebral atrophy; cingulate cortex; cognitive function; cognitive reappraisal; depressed patient; distraction; emotion dysregulation; emotion regulation; emotional distress; executive function; experience; follow-up; healthy aging; middle age; negative affect; network dysfunction; neural network; neural patterning; neuromechanism; novel; preservation; psychologic; recruit; relapse patients; relating to nervous system; response; success; young adult; Adult; Age; Aging; Anterior; Antidepressive Agents; Arousal; Attention; Behavioral; Behavioral Mechanisms; Brain region; Categories; Cognition; Cognitive; Depressed mood; Development; Diagnosis; Dorsal; Elderly; Emotional; Emotions; Factor Analysis; Failure; Foundations; Functional Magnetic Resonance Imaging; Future; Heterogeneity; Impaired cognition; Individual; Intervention; Life; Major Depressive Disorder; Mental Depression; Moods; Patients; Pattern; Pharmaceutical Preparations; Prefrontal Cortex; Prevention; Preventive Intervention; Questionnaires; Recording of previous events; Relapse; Risk; Route; Sex Differences; Stimulus; Testing; Well in self; White Matter Hyperintensity; age group; age related; behavior test; brain volume; causal model; cerebral atrophy; cingulate cortex; cognitive function; cognitive reappraisal; depressed patient; distraction; emotion dysregulation; emotion regulation; emotional distress; executive function; experience; follow-up; healthy aging; middle age; negative affect; network dysfunction; neural network; neural patterning; neuromechanism; novel; preservation; psychologic; recruit; relapse patients; relating to nervous system; response; success; young adult

Older adults tend to have age-related improvement in emotional well-being despite their physical and cognitive decline. The psychological and neural mechanisms of this adult maturational shift in emotion regulation (AMSER) remain to be elucidated. Gross and colleagues have classified emotion regulation (ER) strategies into antecedent-focused (i.e., modifying emotional situations before making a full response, such as selectively attending positive and avoiding negative stimuli or cognitive reappraisal through reinterpreting negative situations to less negative, etc.) and response-focused (expressive suppression). Habitual use of effective ER strategies is associated with emotional well-being. Yet, the empirical evidence on which ER strategy older adults habitually use remains sparse and mixed. Generally, successful voluntary ER in younger and middle- aged adults depends critically on executive control of the executive control network (ECN) on heightened emotional salience in salience network (SN) and the emotional processing and reactivity network (ERN); whereas involuntary ER depends on the ventromedial prefrontal cortex (vmPFC) of the default-mode network (DMN) to regulate SN & ERN. Given the age-associated decrease of brain volume in the dorsal executive prefrontal regions (mainly ECN) and relatively preserved volume in ventral prefrontal regions (such as vmPFC), we hypothesize that older adults use the vmPFC in the DMN as a driver to regulate SN/ERN during both voluntary and involuntary ER. This would explain ER failure in older adults with major depression because vmPFC and ECN dysfunction is a key feature in this condition. In contrast, patients with remitted depression (RD) may have success in ER, although a considerable proportion of RD patients relapse (especially older adults). Rumination, a cognitive construct characterized by repetitive attention to emotional distress, increases the risk of depression relapse in RD. However, a robust analysis of factors associated with ER and relapse has not been performed. Therefore, we will investigate the extent to which individuals with RD display the normative AMSER and identify associated factors. Our study will include 45 healthy adults and 45 major depression patients 45–75 years old in a remitted state and free of medication with 15 subjects in each diagnosis x age group (45–55, 55–65, 65–75 years old). We will employ emotional oddball and reappraisal tasks to examine involuntary and voluntary ER on positive and negative affect separately. Our specific aims are to identify 1) behavioral and 2) neural patterns of AMSER in healthy and RD adults. We will also explore the association of cognitive function and successful ER, as well as sex differences in AMSER in both groups. Our working hypotheses are: RD subjects are heterogeneous in ER; Those using maladaptive ER (rumination) may elicit lower functional connectivity of DMN with ECN and SN/ERN during both involuntary and voluntary ER, which will be associated with poor mood reduction and higher future relapse rates. Successful completion of this project will establish a foundation for further studies and inform future development of novel preventions.

老年人的身体和认知能力与年龄相关的情感福祉任务有所改善 衰退。这种成人情绪调节中这种成人成熟转移的心理和神经机制 （AMSER）仍然有待阐明。总体和同事对情绪监管（ER）策略进行了分类 进入以前的针对性（即，在做出完整反应之前修改情绪状况，例如有选择地 通过重新诠释负面的负面刺激或认知重新评估，参加积极的刺激或认知重新评估 较少的负面情况等）和以响应为中心（表达性抑制）。习惯使用有效的ER 策略与情感健康有关。然而，较旧战略的经验证据 成人习惯性地使用稀疏和混合。通常，在年轻和中期成功的自愿性ER 老年成年人严重依赖执行控制网络（ECN）的执行控制 显着性网络（SN）以及情绪处理和反应性网络（ERN）中的情感显着性； 而非自愿ER取决于默认模式网络的腹膜前额叶皮层（VMPFC） （DMN）调节SN＆ERN。考虑到与年龄相关的背部高管大脑体积减少 前额叶区域（主要是ECN）和腹前额叶区域（例如VMPFC）的相对量 我们假设老年人在DMN中使用VMPFC作为驱动程序，以调节这两个期间的SN/ERN 自愿和非自愿性ER。这将解释大抑郁症老年人的ER失败，因为 VMPFC和ECN功能障碍是这种情况下的关键功能。相反，患有抑郁症的患者 （RD）尽管RD患者中继（尤其是年龄较大）的考虑比例可能会在ER中取得成功 成年人）。反省，一种认知结构，其特征是对情绪困扰的重复关注，增加 RD抑郁症的风险。但是，对与ER和继电器相关的因素的强大分析具有 没有执行。因此，我们将调查患有RD的个人显示的程度 正常AMSER并识别相关因素。我们的研究将包括45位健康的成年人和45个专业 抑郁症患者在拒绝状态下45-75岁，没有药物，每个受试者有15名 诊断X年龄组（45-55、55-65、65-75岁）。我们将采用情感odball和重新评估 在积极和负面影响上检查非自愿和自愿性ER的任务。我们的具体目标 确定1）行为和2）健康和RD成年人中AMSER的神经模式。我们还将探索 认知功能和成功的ER以及两组AMSER的性别差异的关联。 我们的工作假设是：RD受试者在ER中是异质的；那些使用适应不良的ER（反思） 可能在非自愿和自愿期间引起DMN与ECN和SN/ERN的功能连通性较低 ER，这将与降低情绪和更高的未来继电器率有关。成功完成 该项目将为进一步的研究建立基础，并为未来的新预防发展提供信息。