High-speed panoramic 3D photoacoustic computed tomography of the breast

乳房高速全景 3D 光声计算机断层扫描

• 批准号: 9978760
• 负责人: Lihong Wang
• 金额: $ 93.51万
• 依托单位: CALIFORNIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9978760
• 关键词: 3-Dimensional; Acoustics; Benign; Biopsy; Blood Vessels; Breast; Breast biopsy; Clinical; Contrast Media; Detection; Development; Diagnosis; Diagnostic; Elasticity; Gold; Hemoglobin; Hemorrhage; Image; Imaging technology; Ionizing radiation; Lasers; Lead; Lesion; Light; Malignant - descriptor; Mammary Gland Parenchyma; Mammographic screening; Mammography; Methods; Modeling; Morphologic artifacts; Motion; Operative Surgical Procedures; Optics; Oxygen; Pain; Pathology; Patients; Penetration; Resolution; Roentgen Rays; Scanning; Shapes; Speed; Stress; System; Systemic Therapy; Testing; Time; Tissues; Tumor Volume; Ultrasonography; X-Ray Computed Tomography; attenuation; breast cancer diagnosis; breast imaging; breast lesion; clinically significant; cost; diffuse optical tomography; disease diagnosis; elastography; follow-up; imager; imaging system; in vivo; innovation; public health relevance; response; screening; side effect; soft tissue; spatiotemporal; temporal measurement; tomosynthesis; tool

ABSTRACT (30 Lines Max) Objective: Develop two innovative high-speed 3D breast photoacoustic computed tomography (PACT) systems to diagnose benign, atypical, and malignant lesions — leading to a more streamlined and accurate workup that reduces unnecessary follow-up imaging and benign breast biopsies. Clinical significance: Abnormal findings detected by screening mammography lead to workups including additional imaging, usually in the form of extra mammogram views, tomosynthesis, and/or ultrasound, and possibility of breast biopsy. Biopsies have considerable side effects such as pain and bleeding, and are unnecessary in the majority (60 – 70%) of cases because of the high false-positive rate of mammography. The side effects, costs, and delays of the workups cause considerable stress to patients. PACT combines the functional optical contrast of diffuse optical tomography and the high spatial resolution of ultrasonography without speckle artifacts. The attenuation coefficient of near-IR light in breast tissue is only twice that of mammographic x-ray—enabling adequate optical penetration, but light has far higher soft-tissue contrast than x-ray. With rich functional contrast at high spatial and temporal resolutions and without using ionizing radiation or exogenous contrast agents, 3D breast PACT has the potential to reduce unnecessary benign breast biopsies by serving as a diagnostic tool adjunct to mammography. Possible long-term breast imaging applications include not only diagnosis, but also screening, assessment of response to pre-operative systemic therapy, and definitive surgical planning. Challenges: Numerous innovations are required to develop a PACT imaging system effective for clinical breast imaging. Previous PACT breast imagers possess significant limitations, including suboptimal light delivery, limited detection view, non-isotropic spatial resolution, and long scanning times. There remains an imperative need for more advanced PACT breast imaging technologies. Solutions: Encouraged by the preliminary deep and clear in vivo breast images acquired by our newly developed PACT system, we propose further innovations for 3D functional breast imaging to overcome the above-mentioned limitations. Aim 1: To develop a single-breath-hold 3D breast imaging system with nearly isotropic 3D resolutions and dual-wavelength contrasts (Model I). Aim 2: To develop a snapshot 3D breast PACT system (Model II) using the concept of acoustic ergodicity. It can reach the ultimate imaging speed (single laser shot), desirable for 3D high-resolution functional and dynamic imaging without motion artifacts. Both systems can perform elastography. Contrasts to be imaged include vascularity, concentration and oxygen saturation of hemoglobin, elasticity, and tumor volume and shape. Aim 3: To test PACT for the diagnosis of benign, atypical, and malignant breast lesions by comparing with the gold standard of tissue pathology.

摘要（最大30行） 目的：开发两个创新的高速3D乳房光声计算机断层扫描（PACT） 诊断良性，非典型和恶性病变的系统 - 导致更精简和准确 减少不必要的后续成像和良性乳房活检的工作。 临床意义：通过筛查乳房X线摄影检测到的异常发现导致检查包括 其他成像，通常以额外的乳房X线照片观点，断层和/或超声检查的形式，以及 乳房活检的可能性。活检具有相当大的副作用，例如疼痛和出血，并且是 由于乳房X线摄影的假阳性率很高，因此在大多数病例中（60-70％）不必要。这 副作用，成本和检查的延迟给患者带来了很大的压力。条约结合了 弥漫性光学断层扫描和高空间分辨率的功能性光学对比度 没有斑点伪像。乳房组织中近红外光的衰减系数仅是 乳房X线X射线X射线 - 具有足够的光渗透，但光组织对比度远高于 X射线。在高空间和临时分辨率下具有丰富的功能对比，并且不使用电离辐射 或外源性对比剂，3D乳房条约有可能减少不必要的良性乳房 通过作为乳房X线摄影的诊断工具辅助手术。可能的长期乳房成像 应用不仅包括诊断，还包括筛查，评估对术前系统的反应 治疗和明确的手术计划。 挑战：开发有效临床的契约成像系统需要进行大量创新 乳房成像。以前的协定乳房图像具有重大局限性，包括次优光 输送，有限的检测视图，非等于的空间分辨率和较长的扫描时间。仍然有一个 对更先进的PACT乳房成像技术的势在必行。 解决方案：由我们新的新的体内乳房图像的初步深清晰的乳房图像所鼓励 开发的协议系统，我们提出了3D功能性乳房成像的进一步创新，以克服 上述限制。目标1：开发一个几乎具有的单呼吸3D乳房成像系统 各向同性3D分辨率和双波长对比度（Model I）。目标2：开发快照3D乳房 Pact System（II型）使用声学成真的概念。它可以达到最终的成像速度 （单激光射击），对于3D高分辨率功能和动态成像而无需运动伪影。 两种系统都可以执行弹性图。对比的对比包括血管性，浓度和氧气 目标3：测试契约以诊断血红蛋白，弹性以及肿瘤的体积和形状。 通过与组织病理学的金标准相比，良性，非典型和恶性乳房病变。