Melanoma detection by optical spectroscopy

通过光谱检测黑色素瘤

• 批准号: 6761316
• 负责人: Lihong Wang
• 金额: $ 39.24万
• 依托单位: TEXAS ENGINEERING EXPERIMENT STATION
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6761316
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; biopsy; cancer information system; clinical biomedical equipment; clinical research; computer assisted diagnosis; computer system design /evaluation; fiber optics; hemoglobin; human subject; melanoma; morphometry; neoplasm /cancer classification /staging; neoplasm /cancer diagnosis; noninvasive diagnosis; phantom model; portable biomedical equipment; rapid diagnosis; reflection spectrometry; time resolved data

DESCRIPTION (provided by applicant): The goal of the proposed research is to develop, test, and validate a preclinical non-invasive optical instrument, based on spectroscopic Oblique Incidence Reflectometry (OIR), for the rapid diagnosis of pre-cancerous and invasive cancerous skin lesions. The underlying hypothesis, which is well supported by our strong preliminary clinical studies, is that quantitative, spatially resolved, optical-spectral (spatio-spectral) images of skin lesions can provide the dermatologist with clinically valuable diagnostic information to supplement his/her clinical judgment about the need for further diagnostic procedures and/or treatments. OIR intentionally breaks the symmetry of diffuse reflectance that exists in its normal-incidence counterpart and, as a result, provides more robust information about the interrogated tissue volume [Wang et al, US Patent, 5,630,423 (1997)]. A preliminary clinical study of 102 skin lesions using a handheld fiber-optic probe showed that the OIR spectroscopic system differentiated cancerous/pre-cancerous skin lesions from benign lesions with better than 95% accuracy. The applicants have identified the key diagnostic physiological parameters to be (1) the oxygen saturation of hemoglobin, (2) the concentration of total hemoglobin, and (3) the cell-nuclear size. The engineering goal of this proposal is to improve the prototype OIR system to measure skin lesions in real-time and process the data optimally for accurate lesion classification. The mechanistic goal is to identify and quantify the tissue and cellular factors that are responsible for the diagnostic optical features. The clinical goal is to provide accurate, objective, and real-time diagnoses for benign, pre-cancerous, and malignant lesions that are difficult to diagnose clinically. The ultimate societal impact is to improve patient care, save lives, and reduce health care costs. The Specific Aims are listed as follows. 1. To improve instrumentation. 2. To establish a statistically significant database. 3. To develop and validate a diagnostic algorithm. 4. To identify the pathophysiologic parameters responsible for the diagnostic optical features.

描述（由申请人提供）： 拟议的研究的目的是基于光谱倾斜的发生率反映仪（OIR）开发，测试和验证一种临床前的非侵入性光学仪器，以快速诊断前癌性和侵入性癌性皮肤病变。我们强大的初步临床研究得到了很好的支持，即皮肤病变的定量，空间分辨，光光谱（空间 - 光谱）图像可以为皮肤科医生提供临床上有价值的诊断信息，以补充他/她需要进一步诊断程序和治疗的临床判断。 OIR故意打破了其正常含量对应物中存在的弥漫性反射率的对称性，结果提供了有关询问的组织体积的更强大的信息[Wang等，美国专利，5,630,423（1997）]。使用手持纤维探针对102个皮肤病变进行的初步临床研究表明，OIR光谱系统从精度高于95％的良性病变中分化了癌症/癌性皮肤病变。申请人已经确定关键的诊断生理参数为（1）血红蛋白的氧饱和度，（2）总血红蛋白的浓度，以及（3）细胞 - 核大小。该提案的工程目标是改善原型OIR系统，以实时测量皮肤病变，并最佳地处理数据以进行准确的病变分类。机械目标是识别和量化负责诊断光学特征的组织和细胞因子。临床目标是为临床上难以诊断的良性，癌症和恶性病变提供准确，客观和实时诊断。最终的社会影响是改善患者护理，挽救生命并降低医疗保健成本。具体目标如下列出。 1。改善仪器。 2。建立一个具有统计学意义的数据库。 3。开发和验证诊断算法。 4。确定负责诊断光学特征的病理生理参数。