Improved Manufacturing Processes for Advanced Imaging Ag

改进先进成像银的制造工艺

• 批准号: 7051774
• 负责人: ROBERT D BOLSKAR
• 金额: $ 10万
• 依托单位: TDA RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-20 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7051774
• 关键词: bioimaging /biomedical imaging; carbon; chemical synthesis; contrast media; gadolinium; magnetic resonance imaging; molecular shape; technology /technique development

DESCRIPTION (provided by applicant): Endohedral metallofullerenes are spherical fullerene carbon cages confining one or more metal atoms in their interior spaces. Biomedical applications exploiting special properties of metallofullerenes in different areas are promising, including diagnostic and imaging agents (magnetic resonance imaging (MRI) contrast agents, X-ray contrast agents, radiotracers), therapeutic nuclear medicine, antioxidants and biosensors. In our development of Gd-containing endohedral metallofullerenes as paramagentic MRI contrast agents, we have recognized the need for expanding the available raw materials beyond just the soluble Gd@C82 metallofullerenes, which comprise only about 4% of the sublimable Gd metallofullerenes produced by the carbon arc process. We propose to combine new advances in the areas of metallofullerene production and post-production processing to both increase the yield of generated metallofullerenes and to separate and purify the large majority of Gd endohedrals that the current processes can not access. Separative processing based on a chemical redox strategy will allow us to utilize all of the available Gd metallofullerenes by differentiating them into different classes based on their physical and chemical properties. Careful analytical evaluation of the obtained Gd metallofullerene fractions will be performed, allowing evaluation and comparison to other processes for the first time. These advances will benefit the development of MRI contrast applications with metallofullerenes by creating means to generate more raw material while separating the mixture of produced metallofullerenes into useful, homogeneous fractions. In summary, this project will improve processes for manufacture and purification of new materials that are the main ingredient in a new type of useful drug. These can help improve MRI scans used for detecting diseases and are also potentially useful for other medical treatments and applications.

描述（由申请人提供）：内嵌金属富勒烯是球形富勒烯碳笼，其内部空间限制了一个或多个金属原子。利用金属富勒烯的特殊性质在不同领域的生物医学应用前景广阔，包括诊断和成像剂（磁共振成像（MRI）造影剂、X射线造影剂、放射性示踪剂）、治疗性核医学、抗氧化剂和生物传感器。在我们开发含 Gd 的内嵌金属富勒烯作为顺磁力 MRI 造影剂的过程中，我们认识到需要扩大可用原材料的范围，而不仅仅是可溶性 Gd@C82 金属富勒烯，后者仅占碳生产的可升华 Gd 金属富勒烯的 4% 左右。电弧过程。我们建议将金属富勒烯生产和生产后加工领域的新进展结合起来，以提高生成的金属富勒烯的产量，并分离和纯化当前工艺无法获得的大部分 Gd 内嵌体。基于化学氧化还原策略的分离处理将使我们能够利用所有可用的钆金属富勒烯，根据其物理和化学性质将它们分为不同的类别。将对获得的钆金属富勒烯馏分进行仔细的分析评估，从而首次能够与其他工艺进行评估和比较。这些进步将有利于金属富勒烯的 MRI 对比应用的发展，通过创造产生更多原材料的方法，同时将产生的金属富勒烯的混合物分离成有用的均匀部分。总之，该项目将改进作为新型有用药物主要成分的新材料的制造和纯化工艺。这些可以帮助改进用于检测疾病的 MRI 扫描，并且对于其他医学治疗和应用也可能有用。