Perchlorate Sensing Platform for In-Field Groundwater Monitoring

用于现场地下水监测的高氯酸盐传感平台

• 批准号: 8781675
• 负责人: ROBERT D BOLSKAR
• 金额: $ 15万
• 依托单位: TDA RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-12 至 2016-09-11
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8781675
• 关键词: Anions; Biological Assay; Cells; Chemicals; Child; Communication; Computers; Concentration measurement; Containment; Data; Detection; Development; Devices; Environment; Equipment; Evaluation; Exposure to; Fetus; Fluorescence; Food Supply; Goals; Government; Indium; Infant; Ingestion; Iodides; Kinetics; Laboratories; Left; Manufacturer Name; Marketing; Measurement; Measures; Methods; Monitor; Perchlorates; Persons; Phase; Production; Property; Pump; Quantum Dots; Reagent; Research; Safety; Sampling; Scheme; Site; Solutions; Source; Specificity; Surface; System; Technology; Testing; Thyroid Gland; Thyroid Hormones; Time; Water; Water Pollutants; Work; analytical method; aqueous; chemical synthesis; commercialization; computer network; cost; drinking water; improved; innovation; instrumentation; laptop; miniaturize; operation; physical property; prototype; public health relevance; remediation; research and development; response; sensor; uptake; wasting; water sampling

DESCRIPTION (provided by applicant): New and improved technologies are needed for monitoring perchlorate contamination in groundwater. TDA Research Inc. proposes a new portable sensor platform for in-the-field monitoring of the perchlorate anion, ClO4-, for which the recommended remediation goal is less than 3.6 parts-per-billion (3.6 ppb) in water. Perchlorate is a toxic anion that interferes with the uptake of iodide (a necessary element in thyroid hormones) by the thyroid. This inhibition decreases the production of thyroid hormones; thus, exposure to perchlorate needs to be avoided by the developing fetus as well as by infants and children. Perchlorate is highly water soluble, stable, and difficult to detect by chemical or instrumental means. It can be transported by groundwater over long distances, leading to extensive and persistent contamination. Both drinking water sources and food supplies can be contaminated by perchlorate. Therefore, detecting and quantifying perchlorate is a priority for safety and for remediation efforts. On-site, portable methods for quantifying and remote monitoring of perchlorate in the field are particularly sought to reduce the number of laboratory analyses, reduce costs and facilitate the automated acquisition and communication of real-time concentration data. Monitoring such low levels of perchlorate is difficult even in the laboratory, and is especially hard in the field, where a rugged analyzer is needed for unattended operation. In this project we will provide an improved method for the analytical quantification of perchlorate in water by combining new perchlorate-specific chemosensors with advances in spectrofluorimetry equipment. In Phase I we will synthesize a new chemosensor probe, validate its sensitivity (the ClO4- detection limit in parts-per-billion (ppb), with a goal of high parts-pe-trillion (ppt) accuracy) and selectivity (specificity for ClO4- in the presence of other anions), ad demonstrate its utility with field-portable instrumentation. In Phase II and later project phases w will develop an integrated device for the real-time on-site remote quantification of ClO4- in water samples. The sensor platform will be rapid, portable and computer-controlled, for ready interface with other types of groundwater probes and compatible with computer network data communication. The commercial products created in this work will support the identification, monitoring and cleanup of water at sites contaminated with perchlorate.

描述（由申请人提供）：需要新的和改进的技术来监测地下水中的高氯酸盐污染。 TDA Research Inc.提出了一个新的便携式传感器平台，用于对高氯酸盐阴离子（Clo4-）进行内场监测，为此 推荐的补救目标在水中少于3.6亿（3.6 ppb）。高氯酸盐是一种有毒阴离子，会干扰甲状腺的摄取（甲状腺激素中的必要元素）。这种抑制减少了甲状腺激素的产生。因此，发展胎儿以及婴儿和儿童需要避免暴露于高氯酸盐。高氯酸盐是高度水溶性，稳定且难以通过化学或工具手段检测到的。它可以在长距离内通过地下水运输，从而导致广泛而持续的污染。饮用水源和食品供应都可以被高氯酸盐污染。因此，检测和量化高氯酸盐是安全和补救工作的优先事项。特别寻求量化和远程监测高氯酸盐的现场方法，以减少实验室分析的数量，降低成本并促进实时浓度数据的自动化收购和通信。即使在实验室中，也很难监测这种低水平的高氯酸盐，并且在现场尤其难以进行无人看管的分析仪。在这个项目中，我们将提供一种改进的高氯酸盐分析定量的方法 在水中，通过将新的高氯酸盐特异性化学传感器与光谱设备的进步相结合。在第一阶段，我们将合成一个新的化学传感器探针，验证其敏感性（clo4-二十亿（PPB）的检测极限，其目标是高零件-PE-TRILK-TRISTION（PPT）精度）和选择性（特异性（特异性）（ clo4-在存在其他阴离子的情况下），AD证明了其用野外式仪器的实用性。在第二阶段和后来的项目阶段中，W将开发一种集成设备，用于实时对水中的clo4-的实时远程定量 样品。传感器平台将是快速，便携式和计算机控制的，用于与其他类型的地下水探针的现成接口，并与计算机网络数据通信兼容。这项工作中创建的商业产品将支持在被高氯酸盐污染的地点进行识别，监视和清理水。