Novel Polymer Matrix for Dental Applications

用于牙科应用的新型聚合物基质

基本信息

  • 批准号:
    8646407
  • 负责人:
  • 金额:
    $ 18.25万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-08-01 至 2017-01-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Dental caries are the most common childhood disease in the United States. Dental sealants are materials that are applied to the pits and fissures of healthy teeth to prevent dental caries or other forms of decay. This method prevents bacteria ingress and acid dissolution and targets the portions of the tooth surface where ~90% of the decay develops. Peer-reviewed research incontrovertibly substantiates that sealants are safe and effective in preventing caries on both primary and permanent teeth (> 90% reduction in caries on the sealed surface). The application of sealants is minimally invasive, painless and is typically well-accepted by patients, and sealants are a valuable tool to reduce overall dental care costs. Two major classes of materials have been used as sealants: glass ionomers and resins based sealants. Glass ionomers release fluoride that provides some antimicrobial and re-mineralization activity; however they have a higher water uptake, poorer retention and higher micro-leakage scores. Photo-curable methacrylate-based resins have better retention but failures rates are still unacceptably high; they de-bond and chip off the tooth surface within a few years from application and don't last through childhood. A significant increase of the sealant's lifetime is required to make this preventive treatment more cost- effective. Premature sealant loss reduces the effectiveness of this preventive treatment and it is one of the reasons why it is underused in the U.S., where less than 50% of children receive it. It is believed that poor retention of methacrylate-based sealants is due to a combination of hydrolytic degradation of the polymer matrix and mechanical failure, especially related to fatigue under the forces of mastication. The dental profession awaits the development of a modern, more durable, resin-based sealant. This research will develop a novel polymer matrix for sealants that is characterized by excellent mechanical properties under cyclic fatigue, near-zero polymerization shrinkage, and which is not sensitive to hydrolytic degradation in the oral environment. Aside from improving pediatric health, the economic stakes for U.S. health services are staggering; Medicaid dental expenditures for children alone is projected to increase from $4.8 billion in 2010 to more than $12.6 billion in 2020. Since the majority of this spending is for treating caries, the development of a new class of durable, expanded lifetime dental sealant materials that provide more effective and more widely adopted prevention could significantly reduce these expenses. If sealants with an optimal retention rate are developed, the cost of this preventive treatment will be low compared to its benefit, especially considering that implementation can be carried out by adjunct dental personnel in private dental offices or off-site public health initiatives. The need or novel and improved dental sealants is therefore significant. Further, the demand for pit and fissure sealants is expected to growth by more than 7% annually driven by increased acceptance by dentists and patients and new legislation that provides broader access to preventive dental care.
描述(由申请人提供):龋齿是美国最常见的儿童疾病。牙科密封剂是应用于健康牙齿的凹坑和裂缝的材料,以防止龋齿或其他形式的腐烂。该方法可防止细菌输入和酸溶解,并靶向约90%衰减的牙齿表面部分。同行评审的研究无可争议地证明,密封剂可安全有效地防止龋齿的原发性和永久牙齿(密封表面上的龋齿降低> 90%)。密封剂的应用微创,无痛,通常受到患者的良好认可,而密封剂是降低整体牙科护理成本的宝贵工具。两种主要的材料已经用作密封剂:玻璃离子体和树脂基密封剂。玻璃离子体释放氟化物,可提供一些抗菌和再矿化活性;但是,它们的吸水量较高,保留率较差和微肠的得分较高。可抗光抗甲基丙烯酸酯的树脂具有更好的保留率,但失败率仍然不可接受。他们在几年内脱离键并从牙齿表面上碎裂,并且不会持续到童年。需要大幅度增加密封剂的生命周期,以使这种预防性治疗更具成本效益。过早的密封剂损失降低了这种预防治疗的有效性,这是美国不到50%的儿童接受它的原因之一。据认为,甲基丙烯酸酯基密封剂的保留不佳是由于聚合物基质的水解降解和机械故障的结合,尤其是在咀嚼力下与疲劳有关。牙科专业正在等待一种现代,更耐用,基于树脂的密封剂的开发。这项研究将为密封剂开发一种新型的聚合物矩阵,其特征是在环状疲劳下,接近零聚合收缩下的优秀机械性能,并且对口服环境中的水解降解不敏感。除了改善小儿健康外,美国卫生服务的经济风险令人震惊。仅针对儿童的医疗补助牙科支出预计将从2010年的48亿美元增加到2020年的126亿美元。由于大多数支出用于治疗龋齿,所以 开发一类新的耐用,扩展的寿命密封剂材料,可提供更有效和更广泛的预防,可以大大降低这些费用。如果开发具有最佳保留率的密封剂,则与其利益相比,这种预防治疗的成本将很低,尤其是考虑到辅助牙科人员可以在私人牙科办公室或现场公共卫生倡议中执行实施。因此,需求或新颖和改进的牙齿密封剂是显着的。此外,由于牙医和患者的接受以及新的立法,预计对凹坑和裂缝密封剂的需求预计每年将增加7%以上,从而为预防性牙科护理提供更广泛的机会。

项目成果

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ROBERT D BOLSKAR其他文献

ROBERT D BOLSKAR的其他文献

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{{ truncateString('ROBERT D BOLSKAR', 18)}}的其他基金

Perchlorate Sensing Platform for In-Field Groundwater Monitoring
用于现场地下水监测的高氯酸盐传感平台
  • 批准号:
    8781675
  • 财政年份:
    2014
  • 资助金额:
    $ 18.25万
  • 项目类别:
Quantum Dot Sensors for Superfund Priority Substances
用于超级基金优先物质的量子点传感器
  • 批准号:
    8455040
  • 财政年份:
    2012
  • 资助金额:
    $ 18.25万
  • 项目类别:
Fullerene Immunoconjugates for Cancer Imaging and Treatment
用于癌症成像和治疗的富勒烯免疫偶联物
  • 批准号:
    7272908
  • 财政年份:
    2007
  • 资助金额:
    $ 18.25万
  • 项目类别:
Fullerene Immunoconjugates for Cancer Imaging and Treatment
用于癌症成像和治疗的富勒烯免疫缀合物
  • 批准号:
    7501234
  • 财政年份:
    2007
  • 资助金额:
    $ 18.25万
  • 项目类别:
Superior Coatings for Semiconductor Quantum Dots
半导体量子点的优质涂层
  • 批准号:
    7271626
  • 财政年份:
    2007
  • 资助金额:
    $ 18.25万
  • 项目类别:
Improved Safe Alternative to Semiconductor Quantum Dots
改进的半导体量子点的安全替代品
  • 批准号:
    6932711
  • 财政年份:
    2005
  • 资助金额:
    $ 18.25万
  • 项目类别:
Improved Manufacturing Process for Advanced Imaging Agents
改进先进显像剂的制造工艺
  • 批准号:
    7638598
  • 财政年份:
    2005
  • 资助金额:
    $ 18.25万
  • 项目类别:
Improved Manufacturing Processes for Advanced Imaging Ag
改进先进成像银的制造工艺
  • 批准号:
    7051774
  • 财政年份:
    2005
  • 资助金额:
    $ 18.25万
  • 项目类别:
Cut Nanotube Capsules for MR Imaging (RMI)
用于 MR 成像 (RMI) 的切割纳米管胶囊
  • 批准号:
    6965101
  • 财政年份:
    2005
  • 资助金额:
    $ 18.25万
  • 项目类别:
Cut Nanotube Capsules for MR Imaging (RMI)
用于 MR 成像 (RMI) 的切割纳米管胶囊
  • 批准号:
    7140388
  • 财政年份:
    2005
  • 资助金额:
    $ 18.25万
  • 项目类别:

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