Cut Nanotube Capsules for MR Imaging (RMI)

用于 MR 成像 (RMI) 的切割纳米管胶囊

• 批准号: 7140388
• 负责人: ROBERT D BOLSKAR
• 金额: $ 14.65万
• 依托单位: TDA RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7140388
• 关键词: NIH Roadmap Initiative tag; bioimaging /biomedical imaging; carbon; contrast media; cytotoxicity; laboratory rat; magnetic resonance imaging; molecular /cellular imaging; nanotechnology; technology /technique development; transmission electron microscopy

DESCRIPTION (provided by applicant): This project will investigate a new class of potent magnetic resonance imaging (MRI) contrast agents based on cut carbon nanotubes filled with magnetic nanomaterials. These materials will function as protective nanocapsules for the delivery of magnetic materials and offer orders-of-magnitude improvement in MR contrast enhancement, vital to achieving the goal of cellular and molecular imaging with MRI. Synthetic efforts towards filling the cut nanotubes and derivatizing their outer surfaces for water solubility and biocompatibility will be central. Physical characterization of this new class of MRI contrast agent, including relaxometry by NMRD will provide insight into their relaxation mechanisms and offer avenues for further improvement. Collaboration with experts in toxicology and radiology will establish their suitability for eventual clinical investigations. The new platform technology to be created in this project offers a unique paradigm in MRI contrast enhancement useful for broad applications as both an implement in the medical research toolkit as well as for clinically relevant MRI contrast agents for the detection and improved treatment of disease.

描述（由申请人提供）：该项目将研究基于含有磁性纳米材料的切割碳纳米管的新一类有效的磁共振成像（MRI）对比剂。这些材料将充当保护性的纳米胶囊，可用于传递磁性材料，并在MR对比度增强方面提高了魔力级，对于实现MRI的细胞和分子成像至关重要。 填充切割的纳米管并衍生其外表面以提高水的溶解度和生物相容性将是中心的合成努力。这种新的MRI对比剂的物理表征，包括NMRD的松弛时间计，将洞悉其放松机制，并提供进一步改进的途径。与毒理学和放射学专家的合作将确定其最终临床研究的适用性。该项目要创建的新平台技术为MRI对比度增强提供了独特的范式，可用于广泛应用，因为医学研究工具包中的实施以及临床相关的MRI对比剂，可用于检测和改善疾病的治疗。