Hyperpolarized C-13 MR Pulse Sequence Developments for Novel Contrast

用于新型对比度的超极化 C-13 MR 脉冲序列开发

• 批准号: 8327061
• 负责人: Peder Eric Zufall Larson
• 金额: $ 22.81万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8327061
• 关键词: Animals; Award; Bicarbonates; Biochemistry; Biological; Biological Markers; Biomedical Engineering; Blood; Cancer Patient; Carbon; Chemistry; Collaborations; Complex; Detection; Development; Development Plans; Disease; Electrical Engineering; Engineering; Exposure to; Faculty; Future; Goals; Human; Image; Imaging Techniques; Investigation; Label; Magnetic Resonance Imaging; Malignant Neoplasms; Malignant neoplasm of prostate; Mentors; Metabolic; Metabolism; Methods; Mus; New Agents; Pathology; Pathway interactions; Perfusion; Physics; Physiologic pulse; Pyruvate; Pyruvate Metabolism Pathway; Radiology Specialty; Reproducibility; Research; Research Personnel; Scheme; Signal Transduction; Solid; Source; Techniques; Time; Tissues; Translations; Urea; Wild Type Mouse; Work; abstracting; base; bioimaging; biological systems; cancer imaging; career development; clinical application; design; imaging modality; improved; in vivo; interest; member; method development; novel; pre-clinical research; preclinical study; reconstruction; response; tumor; uptake

Project Summary/Abstract This project outlines technical bioengineering developments for new types of image contrast in the emerging field of hyperpolarized carbon-13 MRI. Preliminary research in this field is extremely promising, particularly for cancer applications, and the first human trials in prostate cancer patients are slated to occur at UCSF within 6 months. This "Pathway to Independence" award application includes a mentored career development plan for transition of the candidate, Dr. Peder Larson, into an independent investigator, as well an accompanying research plan describing the proposed technical developments for hyperpolarized carbon-13 MR. The candidate, Dr. Peder Larson, is currently a Postdoctoral Scholar at UCSF working on technical developments for hyperpolarized carbon-13 MRI. His graduate work was in Electrical Engineering at Stanford and focused on improving MRI of semi-solid tissues, which are invisible in conventional MRI. The mentoring and career development plan will supplement his engineering background with valuable exposure to hyperpolarization physics and chemistry, biological systems and biochemistry, pre-clinical research, and inter-disciplinary collaboration to facilitate the transition to an independent bioengineering investigator. His goals are to become a faculty member in bioengineering or radiology where he can research technical biomedical imaging developments with potential clinical applications. Hyperpolarized carbon-13 MRI requires specialized methods because, unlike conventional MRI, the signal decays rapidly and is unrecoverable. This project proposes rapid and efficient methods for dynamic metabolic imaging to provide localized perfusion, uptake and rate information that are unavailable in current techniques. New sources of contrast with hyperpolarized carbon-13 are also proposed, including a method to distinguish flowing metabolites from those within tissues and development of specialized techniques for multiple carbon-13 agents. Preclinical studies in normal animals will be used for investigation of the new imaging methods. This will facilitate the translation of the methods from development to future clinical application. ) )

项目概要/摘要 该项目概述了新型图像对比度的生物工程技术发展 超极化碳 13 MRI 的新兴领域。该领域的初步研究是 非常有前途，特别是对于癌症应用，以及前列腺的首次人体试验 癌症患者预计在 6 个月内出现在 UCSF。这条“独立之路” 奖项申请包括针对候选人过渡的指导职业发展计划， Peder Larson 博士，独立调查员，以及随附的研究计划 描述了超极化碳 13 MR 的拟议技术发展。 候选人 Peder Larson 博士目前是 UCSF 的博士后学者，致力于 超极化碳 13 MRI 的技术发展。他的毕业作品是电气 斯坦福大学工程学，专注于改善不可见的半固体组织的 MRI 在传统的 MRI 中。指导和职业发展计划将补充他的 具有对超极化物理和化学的宝贵接触的工程背景， 生物系统和生物化学、临床前研究和跨学科合作 促进向独立生物工程研究者的过渡。他的目标是成为 生物工程或放射学的教员，他可以研究生物医学技术 具有潜在临床应用的成像发展。 超极化碳 13 MRI 需要专门的方法，因为与传统 MRI 不同， 信号迅速衰减并且无法恢复。该项目提出了快速、高效的 提供局部灌注、摄取和速率的动态代谢成像方法 当前技术中无法获得的信息。新的对比来源 还提出了超极化碳13，包括一种区分流动的方法 组织内的代谢物以及多种专门技术的开发 碳13剂。正常动物的临床前研究将用于研究新的 成像方法。这将有助于将开发方法转化为未来方法 临床应用。 ） ）