Quantum Dot Sensors for Superfund Priority Substances

用于超级基金优先物质的量子点传感器

• 批准号: 8455040
• 负责人: ROBERT D BOLSKAR
• 金额: $ 15万
• 依托单位: TDA RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-12-10 至 2014-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8455040
• 关键词: Acic; Aromatic Polycyclic Hydrocarbons; Binding; Biological Assay; Boranes; Characteristics; Chemistry; Collaborations; Complex; Coupling; Cyclodextrins; Detection; Elements; Evaluation; Fluorescence; Fluorescent Probes; Fullerenes; Government; Hazardous Substances; High Pressure Liquid Chromatography; Immunoassay; Marketing; Mass Spectrum Analysis; Methods; Molecular; Monitor; Nanotechnology; Nature; Persons; Phase; Poison; Polychlorinated Biphenyls; Polymers; Property; Quantum Dots; Research; Scheme; Semiconductors; Site; Small Business Innovation Research Grant; Soil; Specificity; Spectroscopy, Fourier Transform Infrared; Superfund; Techniques; Testing; Time; Toxin; United States; Water; base; commercialization; diphenyl; fluorophore; improved; nanoparticulate; public health relevance; research and development; sensor; superfund site

DESCRIPTION (provided by applicant): The principal aim of this project is to obtain proof-of-concept for a new nanotechnology-based sensor material for rapid and sensitive fluorescence detection of polycyclic aromatic hydrocarbons (PAHs) and polychloro biphenyls (PCBs). Simple, cheap and safe methods to detect and quantify these toxic substances, which rank high in the ATSDR Substance Priority List and contaminate many US Superfund priority sites, are highly sought after. Emission-based methods using sensitive and specific fluorescent probes offer improved means to do this. Our plan will create new chemosensors useful for detecting and quantifying PAHs and PCBs, including on-site rapid qualitative assays of soil and water of contaminated sites and as analytical probes for the spectrofluorometric quantitization of these high-ranking toxins. In Phase I of this project we will conduct a proof-of-concept study to synthesize new sensor probes and validate their emission properties when challenged with PAH and PCB analytes. The new sensor materials will be useful as rapid and sensitive probes in analytical tests and assays for monitoring the hazardous substances at contaminated Superfund sites.

描述（由申请人提供）：该项目的主要目的是获得基于纳米技术的新传感器材料的概念证明，用于快速和敏感的荧光检测多环芳烃（PAHS）和二氯苯基（PCB）。高度追捧，简单，廉价且安全的方法来检测和量化这些有毒物质，在ATSDR物质优先级中排名很高并污染了许多美国超级基金优先位点。使用敏感和特定荧光探针的基于排放的方法为此提供了改进的方法。我们的计划将创建新的化学传感器，可用于检测和量化PAH和PCB，包括对受污染位点的土壤和水的现场快速定性测定，以及作为这些高级毒素的光谱量化定量化的分析探针。在该项目的第一阶段，我们将进行一项概念验证研究，以合成新的传感器探针并在用PAH和PCB分析挑战时验证其发射特性。新的传感器材料将作为分析测试中的快速和敏感探针有用，并在监测受污染的超级基金部位的有害物质的测定中有用。