Long Field Of View MRA Using Continuous Table Motion

使用连续工作台运动的长视场 MRA

• 批准号: 6935863
• 负责人: Stephen J Riederer
• 金额: $ 36.13万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6935863
• 关键词: angiography; bioimaging /biomedical imaging; biomedical equipment development; clinical research; human subject; image enhancement; magnetic resonance imaging; method development; swine

DESCRIPTION (provided by applicant): We propose to develop the MRI physics acquisition techniques, the RF coil hardware, and the image reconstruction and signal processing methods to allow MR data to be performed during continuous motion of the patient table. Compared to the current, fixed, multi-station approach this offers improved time efficiency and eliminates brightness discontinuities between stations. Further, the use of real-time image reconstruction permits the table velocity to be adjusted in real time to match the observed transit of the contrast bolus on a patient-specific basis. New approaches for use of multiple coils in the lower extremities will permit two-fold reduced acquisition time. The long term goal of the project is to allow high resolution whole body MRI. The overall hypothesis of this project is that high resolution, arterial phase 30 contrast-enhanced MR angiography can be performed using real-time, patient-specific acquisition in conjunction with a continuously moving table. Specific projects to be studied are: 1. MRI Data Acquisition During Continuous Table Motion. The specific technique for data acquisition and correction during continuous table motion will be developed. The tradeoffs between field of view, spatial and time resolution, and velocity will be studied. Phase encode orders will be optimized, and alteration of slab thickness and position during the scan will be studied. Correction algorithms will be developed for magnetic field inhomogeneities and gradient non-linearities. 2. Dual-Coil Imaging. To exploit the non-contiguous fields of view in imaging the legs, an approach using two distinct transmit and receive coils will be developed. By isolating the response of each coil from the other, it is possible to collect data from each leg separately and simultaneously using the same pulse sequence. This is expected to provide a two-fold reduction in acquisition time for given resolution without the processing and noise amplification factors associated with SENSE. 3. Peripheral Runoff Study 3D MRA. The techniques developed in Projects 1 and 2 will be adapted to imaging the peripheral vasculature. Initially, tracking of a test bolus down the legs using a rapid 2D mode will guide the selection of table velocity during the high resolution 3D scan. Eventually, tracking will be done in real-time using fluoroscopic triggering, real-time determination of the bolus front, and dynamic velocity control.

描述（由申请人提供）：我们建议开发MRI物理学采集技术，RF线圈硬件以及图像重建和信号处理方法，以允许在患者表连续运动期间执行MR数据。与当前的固定，多站方法相比，这提供了提高的时间效率，并消除了电台之间的亮度不连续性。此外，实时图像重建的使用允许实时调整表速度，以匹配观察到的对比度推注的转运。在下肢使用多个线圈的新方法将允许减少两倍的获取时间。该项目的长期目标是允许高分辨率全身MRI。该项目的总体假设是，高分辨率，动脉30相对增强的MR血管造影可以与连续移动台结合使用实时，患者特定于患者的习得进行。要研究的特定项目是： 1。连续表运动期间MRI数据采集。将开发连续表运动期间数据采集和校正的特定技术。将研究视野，空间和时间分辨率和速度之间的权衡。相位编码订单将被优化，将研究扫描过程中平板厚度和位置的改变。校正算法将针对磁场不均匀性和梯度非线性开发。 2。双线圈成像。为了利用对腿部成像的不连续视野，将开发使用两种不同的传输和接收线圈的方法。通过将每个线圈的响应与彼此隔离，可以使用相同的脉冲序列分别和同时收集每个腿的数据。预计这将为给定的分辨率提供两倍减少的获取时间，而无需与意义相关的处理和噪声扩增因子。 3。外围径流研究3D MRA。项目1和2中开发的技术将适应成像外周脉管系统。最初，使用快速的2D模式跟踪腿部的测试大通将指导在高分辨率3D扫描期间选择表速度。最终，使用荧光镜触发，推注前的实时确定和动态速度控制将实时进行跟踪。