Super Resolution for Improved Multislice Prostate MRI

超分辨率改进的多层前列腺 MRI

基本信息

批准号：
10661095
负责人：
Stephen J Riederer
金额：
$ 56.55万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-07-10 至 2026-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10661095
关键词：
3-Dimensional Abbreviations Algorithms Cancer Detection Clinical Collaborations Data Development Diagnosis Diagnostic Diffusion Magnetic Resonance Imaging Early Diagnosis Encapsulated Feasibility Studies Grant Image Individual Magnetic Resonance Imaging Malignant - descriptor Malignant Neoplasms Malignant neoplasm of prostate Measures Methodology Methods Motion Normal tissue morphology Outcome Pathology Performance Peristalsis Physiologic pulse Prostate Qualifying Radiology Specialty Relaxation Reporting Resolution Scanning Scheme Screening for Prostate Cancer Slice Survival Rate Techniques Thick Thinness Time Urology Visualization diagnostic accuracy diffusion weighted image reconstruction improved in vivo innovation men rapid technique reconstruction research clinical testing two-dimensional ultra high resolution virtual

项目摘要

PROJECT SUMMARY / ABSTRACT Prostate cancer (PCa) is the most common and second most deadly non-cutaneous cancer in men in the USA, but five-year survival rates approaching 100% are possible if detected early. Prostate MRI has become increasingly important in cancer detection and localization. Two-dimensional (2D) multislice T2-weighted spin-echo (T2SE) and diffusion-weighted (DWI) acquisitions are mainstays of clinical prostate MRI, but radi- ological interpretation is hindered because through-plane resolution is 3–8× coarser than inplane resolution. This is particularly limiting in the transition zone (TZ) of the prostate where differences in relaxation times between malignant and normal tissue are small, and interpretation is often based on sharpness-related criteria such as encapsulation. Per PI-RADSv2.1, T2SE is the critical sequence. Reported sensitivity is far less than ideal, 30 to 70%. In addition to the specific need for improved diagnostic accuracy in the TZ, there is an initiative to make prostate MRI exams shorter and more efficient. Thus, there is a need to reconcile these competing demands of improved resolution and contrast via reduced partial volume effects with higher effi- ciency in prostate MRI. We have developed a super resolution (SR) method for T2SE which uses overlapped, standard-thickness (3mm) axial slices to form 1mm slices with reconstruction in kZ-space, dubbed kZ-multislice (KZM). We have shown in vivo the superior sharpness of the resultant images vs. 3mm slices for equal inplane resolution. More recently we have developed methods which virtually eliminate the slice-to-slice in- consistency disrupting current KZM reconstruction and degrading image quality. Our central hypothesis is that this KZM approach shown in feasibility studies can now be markedly improved technically to simultane- ously provide improved through-plane resolution and allow reduced scan time, resulting in an efficient tech- nique enabling improved performance of clinical prostate T2SE and DWI MRI. We propose to: 1. Develop techniques for rapid, high quality, multislice acquisition suitable for SR prostate T2SE. We will incorporate non-traditional RF excitation pulses for improved fidelity in kZ. We will use simultaneous multi- slice (SMS) to reduce scan time and statistical reconstruction to retain SNR. We will develop means to measure the small, 1-2 mm A/P prostate motion during the scan, allowing accurate motion correction. 2. Extend the SR methodology developed for T2SE to DWI of the prostate. Segmented acquisition will provide for slice-to-slice positional consistency. SR reconstruction will be tuned to the individual b-values used. Sta- tistical reconstruction will retain SNR, allowing thin-slice images of the ADC. 3. Apply SR techniques to multislice prostate MRI. We will evaluate our technical developments in clinical evaluations, comparing conventional T2SE with our new SR method for a Super Abbreviated Exam (SAE). We will also evaluate our T2SE KZM method on improved accuracy in detecting PCa in the transition zone.

项目概要/摘要前列腺癌 (PCa) 是男性中最常见且第二致命的非皮肤癌症美国，但如果及早发现前列腺 MRI，五年生存率可能接近 100%。二维 (2D) 多层 T2 加权在癌症检测和定位中日益重要。自旋回波 (T2SE) 和弥散加权 (DWI) 采集是临床前列腺 MRI 的支柱，但放射逻辑解释受到阻碍，因为平面分辨率比平面分辨率粗 3-8 倍。这在前列腺过渡区 (TZ) 中尤其受到限制，其中松弛时间存在差异恶性组织和正常组织之间的差异很小，并且解释通常基于与清晰度相关的标准例如，根据 PI-RADSv2.1，T2SE 是关键序列，远低于报告的灵敏度。理想情况下，30% 至 70% 除了提高 TZ 诊断准确性的具体需要外，还有一个要求。因此，有必要协调这些检查。通过减少部分体积效应和更高的效率来提高分辨率和对比度的竞争需求我们开发了一种用于 T2SE 的超分辨率 (SR) 方法，该方法使用重叠、标准厚度 (3mm) 轴向切片形成 1mm 切片，并在 kZ 空间中进行重建，称为 kZ 多层切片 (KZM)。我们在体内展示了与相同的 3mm 切片相比所得图像的卓越清晰度。最近，我们开发了几乎消除了切片到切片内分辨率的方法。一致性会破坏当前的 KZM 重建并降低图像质量。可行性研究中显示的这种 KZM 方法现在可以在技术上得到显着改进，以同时有效地提供改进的平面分辨率并减少扫描时间，从而实现高效的技术我们建议： 1. 开发适合 SR 前列腺 T2SE 的快速、高质量、多切片采集技术。结合非传统的射频激励脉冲以提高 kZ 的保真度。我们将开发方法来减少扫描时间和统计重建以保留信噪比。在扫描过程中测量 1-2 毫米 A/P 前列腺小运动，从而实现精确的运动校正。 2. 将为 T2SE 开发的 SR 方法扩展到前列腺的 DWI 分段采集。为了实现切片到切片的位置一致性，SR 重建将根据所使用的各个 b 值进行调整。组织重建将保留 SNR，从而允许 ADC 的薄片图像。 3.将SR技术应用于多层前列腺MRI我们将评估我们在临床上的技术进展。评估，将传统 T2SE 与我们用于超级缩写考试 (SAE) 的新 SR 方法进行比较。我们还将评估我们的 T2SE KZM 方法，以提高检测过渡区 PCa 的准确性。