Reconstruction Hardware for Real-Time Moving Table MRI

用于实时移动台 MRI 的重建硬件

• 批准号: 6783945
• 负责人: Stephen J Riederer
• 金额: $ 36.14万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6783945
• 关键词: angiography; artificial intelligence; bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; clinical research; computer program /software; human subject; image processing; magnetic resonance imaging; mathematics; physics; technology /technique development; time resolved data

DESCRIPTION (provided by applicant): The overall goal of this project is to design and integrate instrumentation allowing the next generation of real-time image formation in MRI. The motivation comes from an existing project for forming MR images during continuous motion of the patient table. When applied to peripheral MR angiography the target is the formation of a moving table angiogram in which the table motion is precisely matched to the transit of the contrast bolus through the patient. However, implementation of this requires that a number of mathematical processes be done at high speed, including: (i) time-resolved 3D MRI of an extended field of view (FOV); (ii) determination of localized time-dependent parameters such as bolus arrival time and bolus velocity; (iii) variable ordering of phase encodings over the course of an MRI scan, allowing optimized local resolution; (iv) gradient warping correction for MR acquisition done using a moving patient table; (v) multi-coil reconstruction using the SENSE technique, allowing improved lateral resolution for a given acquisition time; (vi) MR acquisition done using a variable table velocity When implemented, these methods will allow the formation of peripheral MR angiograms with optimized, patient-specific table motion, maximum efficiency, and high spatial resolution. Specific aims are: 1. Construction of the Next Generation Real-Time Image MR Reconstruction System. The funding will allow the construction of a system enabling the real-time performance of the mathematical algorithms which perform the above processes. System design will allow the data acquisition and reconstruction to be modified in real time. 2. Incorporation of the New System into the Project of Moving Table MRA. Once the hardware is integrated into a useable system it will be interfaced to a clinical MRI scanner at Mayo and used in the formation of peripheral contrast-enhanced MR angiograms using continuous motion of the patient table through the scanner gantry.

描述（由申请人提供）： 该项目的总体目标是设计和集成仪器，从而允许MRI中的下一代实时图像形成。动机来自现有的项目，用于在患者表的连续运动中形成MR图像。当应用于周围MR血管造影时，目标是形成移动桌血管造影，其中表运动与对比度大量通过患者的过境精确匹配。但是，实施此操作要求高速进行许多数学过程，包括：（i）扩展视野（FOV）的时间分辨的3D MRI； （ii）确定局部时间依赖性参数，例如推注到达时间和推注速度； （iii）在MRI扫描过程中，相位编码的变量排序，允许优化局部分辨率； （iv）使用移动的患者表进行的MR采集校正梯度翘曲校正； （v）使用感官技术的多线圈重建，从而可以在给定的采集时间内改善横向分辨率； （vi）MR采集在实施时使用可变表速度进行，这些方法将允许形成具有优化，特定于患者的表运动，最大效率和高空间分辨率的外围MR血管造影。具体目的是：1。下一代实时图像MR重建系统的构建。资金将允许构建系统，从而实现执行上述过程的数学算法的实时性能。系统设计将允许数据采集和重建实时修改。 2。将新系统纳入移动台MRA的项目。一旦将硬件集成到可用的系统中，它将连接到Mayo的临床MRI扫描仪，并使用患者桌子通过扫描仪龙门进行连续运动，用于形成周围对比度增强的MR血管造影。