Long Field Of View MRA Using Continuous Table Motion

使用连续工作台运动的长视场 MRA

• 批准号: 8075673
• 负责人: Stephen J Riederer
• 金额: $ 38.05万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8075673
• 关键词: Abdomen; Acceleration; Accounting; Algorithms; Anatomy; Angiography; Applications Grants; Arteries; Blood flow; Bolus Infusion; Detection; Development; Diagnosis; Diagnostic; Dimensions; Distal; Dose; Goals; Health; Image; Intravenous; Investigation; Lateral; Leg; Lower Extremity; Magnetic Resonance Imaging; Measures; Methodology; Methods; Morphologic artifacts; Motion; Patients; Pelvis; Peripheral; Peripheral Vascular Diseases; Phase; Physics; Physiologic pulse; Physiological; Population; Positioning Attribute; Preparation; Property; R-factor; Resolution; Scanning; Signal Transduction; Simulate; Speed; Techniques; Testing; Time; United States; computerized data processing; data acquisition; experience; foot; improved; in vivo; method development; reconstruction; research clinical testing; resistance factors; Abdomen; Acceleration; Accounting; Algorithms; Anatomy; Angiography; Applications Grants; Arteries; Blood flow; Bolus Infusion; Detection; Development; Diagnosis; Diagnostic; Dimensions; Distal; Dose; Goals; Health; Image; Intravenous; Investigation; Lateral; Leg; Lower Extremity; Magnetic Resonance Imaging; Measures; Methodology; Methods; Morphologic artifacts; Motion; Patients; Pelvis; Peripheral; Peripheral Vascular Diseases; Phase; Physics; Physiologic pulse; Physiological; Population; Positioning Attribute; Preparation; Property; R-factor; Resolution; Scanning; Signal Transduction; Simulate; Speed; Techniques; Testing; Time; United States; computerized data processing; data acquisition; experience; foot; improved; in vivo; method development; reconstruction; research clinical testing; resistance factors

DESCRIPTION (provided by applicant): The long term objective of this project continues to be the development of methods which permit MR data acquisition during continuous motion of the patient table for contrast-enhanced MR angiographic studies of the peripheral vasculature. This will allow diagnostic quality imaging of the vasculature from the abdomen and pelvis to the feet to allow diagnosis and characterization of peripheral vascular disease. Imaging during continuous table motion permits high efficiency in the use of scan time and of the contrast dose. Because a given axial level is imaged within the moving field-of-view for only a limited time, typically 20 sec or less, it is critical to allow improvements in spatial resolution for a given acquisition time. To this end, acceleration techniques demonstrated in Years 01-04 in one dimension will be extended to the two lateral dimensions. Another major aim of the study is to image the contrast dose transit in real time, automatically track its position, and use this information to automatically adjust the table velocity. The grant application includes the following specific aims: 1. High Resolution CE-MRA of a Fixed FOV Using 2D Acceleration Techniques. In preparation for imaging during continuous table motion, techniques will first be developed for performing highly accelerated acquisitions during no table motion within a targeted 16 sec. The elliptical centric view order will be combined with 2D homodyne, 2D SENSE, and time-resolved view-shared acquisition for 1 mm isotropic resolution. 2. Parallel Acquisition Techniques Applied During Continuous Table Motion. The accelerated acquisition methods of Aim #1 will be adapted to continuously moving table imaging. Reconstruction algorithms will be developed which account for gradient warping, 2D SENSE-homodyne, and variable FOV acquisition. Coils will be developed which allow efficient 15x accelerated 2D parallel acquisition over an extended FOV. 3. Patient-Specific Acquisition for Continuously Moving Table Peripheral MRA. Methods will be developed to detect the leading edge of the contrast bolus as it moves along the peripheral vasculature and then to use this information to alter the patient table motion in real time. This will be tested initially in phantoms and then using a test bolus. The final technique will be one in which an extended-FOV, high spatial resolution, arterial phase peripheral angiogram is formed by automatically tracking the full contrast bolus with no need for a test bolus. PUBLIC HEALTH RELEVANCE: Peripheral vascular disease is a major problem in the population of the United States, and it is important to image and diagnosis this condition in an easy, accurate, reliable, safe manner which not only accounts for patient-to-patient differences in anatomy and blood flow but also accommodates the long field of view which ex- tends from the abdomen to the feet. This project is relevant to this problem, as the goal is to develop a method which allows high spatial resolution MR imaging of the extended vasculature by using a moving patient table uniquely tuned to the transit of intravenous contrast material within each patient.

描述（由申请人提供）：该项目的长期目标继续是开发方法，该方法允许在患者表连续运动期间进行MR数据获取，以进行外围脉管系统的对比增强的MR血管造影研究。这将允许对腹部和骨盆的脉管系统进行诊断质量成像，从而允许诊断和表征周围血管疾病。连续桌子运动过程中的成像允许使用扫描时间和对比剂量的高效率。由于仅在有限的时间内（通常为20秒或更短时间）内在移动视野内成像给定的轴向水平，因此在给定的采集时间内允许改进空间分辨率至关重要。为此，在一个维度01-04年中证明的加速技术将扩展到两个横向维度。该研究的另一个主要目的是实时成像对比剂量过境，自动跟踪其位置，并使用此信息自动调整表速度。赠款申请包括以下特定目的：1。使用2D加速技术的固定FOV的高分辨率CE-MRA。为了准备在连续的桌子运动过程中成像，将首先开发用于在目标16秒内无台运动过程中进行高度加速采集的技术。以椭圆形的视图顺序将与2D同源性，2D Sense和时间分辨的视图共享采集相结合，以1毫米的各向同性分辨率。 2。在连续桌子运动中应用的平行采集技术。 AIM＃1的加速采集方法将适应连续移动的表成像。将开发重建算法，以说明梯度翘曲，2D Sense-Homodyne和可变的FOV获取。将开发线圈，该线圈可以在扩展的FOV上加速有效的15倍加速2D并行采集。 3。特定于患者的收购，用于连续移动的外围MRA。将开发方法来检测对比推注沿周围脉管系统移动时的前缘，然后使用此信息实时改变患者表运动。这将最初在幻影中进行测试，然后使用测试推注。最终技术将是一种扩展的fov，高空间分辨率，动脉期外周血管造影是通过自动跟踪不需要测试推注的完整对比度的。公共卫生相关性：周围血管疾病是美国人群中的一个主要问题，重要的是以简单，准确，可靠，安全的方式对此状况进行形象和诊断，这不仅说明了解剖学和血液中患者之间的患者之间的差异，而且还适应了从腹部到脚的较长视野。该项目与此问题相关，因为目标是通过使用移动的患者桌子独特地调整到每个患者内静脉内对比度的过境的转移，从而允许高空间分辨率MR成像对扩展脉管系统进行MR成像。