A dual-layer flat panel x-ray detector based on an engineered amorphous chalcogenide alloy for quantifying coronary artery calcium

基于工程非晶硫属化物合金的双层平板 X 射线探测器，用于量化冠状动脉钙

• 批准号: 10839539
• 负责人: Shiva Abbaszadeh
• 金额: $ 14.13万
• 依托单位: UNIVERSITY OF CALIFORNIA SANTA CRUZ
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-07 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10839539
• 关键词: Acceleration; Address; Affect; Aging; Alloys; American Heart Association; Area; Artificial Intelligence; Award; Behavior; Businesses; Calcium; Cardiac; Cardiovascular Diseases; Cause of Death; Clinic; Cost Savings; Data; Data Collection; Dedications; Defect; Detection; Diagnostic; Discrimination; Dose; Early Diagnosis; Early treatment; Electronics; Emerging Technologies; Engineering; Ensure; Environment; Equipment; Evaluation; Failure; Film; Funding; General Practitioners; Generations; Healthcare Systems; High temperature of physical object; Humidity; Image; Image Enhancement; Investigation; Learning; Legal patent; Licensing; Manufacturer; Measures; Modeling; Morphologic artifacts; Motion; National Institute of Biomedical Imaging and Bioengineering; Noise; Optics; Outcome; Parents; Patients; Pattern; Photons; Preventive measure; Process; Radiation Dose Unit; Readiness; Research; Resolution; Risk; Roentgen Rays; Selenium; Signal Transduction; Small Business Innovation Research Grant; Source; Spottings; Stress Tests; System; Techniques; Technology; Tellurium; Testing; Thinness; Transistors; Uninsured Medical Expense; United States National Institutes of Health; Variant; X-Ray Computed Tomography; X-Ray Medical Imaging; cardiovascular disorder risk; commercialization; coronary artery calcium; cost; cost comparison; density; detector; electric field; electrical property; electronic structure; high risk; improved; industry partner; innovation; manufacture; manufacturing process; new technology; novel; parent project; programs; prototype; quantum; screening; success; theories; trend

ABSTRACT Cardiovascular disease (CVDs) are the leading cause of death globally. According to the American Heart Association, for early treatment of CVD and to verify if a patient should be prescribed statin therapy, calcium scoring via cardiac Computed Tomography (CT) should be performed. However, there is a limited application of calcium scoring due to limited spatial resolution of CT (~1 mm), dose concern, and out of pocket expense for patient. To address the challenges with CT calcium scoring, a new technology based on dual-layer flat panel detector is being developed under our R01 “A dual-layer flat panel X-ray detector based on an engineered amorphous chalcogenide alloy for quantifying coronary artery calcium” to provide opportunistic calcium score whenever X-ray is done. This technology aims to provide an opportunistic approach to X-ray imaging with a detector that improves detection and quantification of coronary artery calcium (CAC). It is based on a patent pending selenium alloy with favorable optical and electrical properties that enhance image quality. Whenever X- ray is done for any reason calcium score automatically is generated with no additional cost burden to healthcare system. To advance the proposed technology from a functioning prototype to readiness level required for licensing to the Original Equipment Manufacturer (OEM), there are areas related to uniformity and variation across detector and yield that should be evaluated and assessed. In this supplement, we will apply our learning from concept to clinic: commercializing innovation (C3i) program to address key areas that are not included in the parent award but needs to be address before being presented to OEM partner. We will develop multiple prototypes to assess the distribution of bad pixels and overall detector yield, as well as identifying any patterns or trends in the distribution of these defects. We will determine the required changes or challenges in integration of the proposed technology to the OEM thin-film transistor backplanes. Leveraging the outcome of this supplement award will significantly strengthen the preliminary data required to address important technical risk related to manufacturing process of the proposed technology to present to OEM partners.

抽象的 据美国心脏协会称，心血管疾病（CVD）是全球主要死亡原因。 协会，用于早期治疗 CVD 并验证患者是否应接受他汀类药物治疗、钙剂治疗 应通过心脏计算机断层扫描 (CT) 进行评分，但其应用有限。 由于 CT 空间分辨率有限（~1 毫米）、剂量问题以及自付费用，钙评分 为了解决 CT 钙评分的挑战，这是一种基于双层平板的新技术。 探测器正在我们的 R01“基于工程设计的双层平板 X 射线探测器”下开发 用于量化冠状动脉钙的非晶态硫属化物合金”以提供机会性钙评分 每当进行 X 射线检查时，该技术旨在提供一种机会性的 X 射线成像方法。 改进冠状动脉钙 (CAC) 检测和定量的检测器 它基于一项专利。 正在开发的硒合金具有良好的光学和电学性能，可提高图像质量。 无论出于何种原因进行射线检查都会自动生成钙分数，不会给医疗保健带来额外的成本负担 将所提出的技术从功能原型推进到所需的准备水平。 向原始设备制造商 (OEM) 授予许可，存在与一致性和变化相关的领域 应该评估和评估整个检测器和产量。 在本增刊中，我们将把我们从概念中学到的知识应用到临床：创新商业化 (C3i) 计划 解决家长奖励中未包含但在颁发前需要解决的关键领域 我们将开发多个原型来评估坏像素的分布和整体探测器。 良率，以及识别这些缺陷分布的任何模式或趋势，我们将确定这些缺陷的分布。 将提议的技术集成到 OEM 薄膜晶体管中所需的改变或挑战 利用该补充奖项的结果将显着加强初步数据。 需要解决与拟议技术的制造过程相关的重要技术风险 赠送给 OEM 合作伙伴。