A dual-layer flat panel x-ray detector based on an engineered amorphous chalcogenide alloy for quantifying coronary artery calcium

基于工程非晶硫属化物合金的双层平板 X 射线探测器，用于量化冠状动脉钙

• 批准号: 10839539
• 负责人: Shiva Abbaszadeh
• 金额: $ 14.13万
• 依托单位: UNIVERSITY OF CALIFORNIA SANTA CRUZ
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-07 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10839539
• 关键词: Acceleration; Address; Affect; Aging; Alloys; American Heart Association; Area; Artificial Intelligence; Award; Behavior; Businesses; Calcium; Cardiac; Cardiovascular Diseases; Cause of Death; Clinic; Cost Savings; Data; Data Collection; Dedications; Defect; Detection; Diagnostic; Discrimination; Dose; Early Diagnosis; Early treatment; Electronics; Emerging Technologies; Engineering; Ensure; Environment; Equipment; Evaluation; Failure; Film; Funding; General Practitioners; Generations; Healthcare Systems; High temperature of physical object; Humidity; Image; Image Enhancement; Investigation; Learning; Legal patent; Licensing; Manufacturer; Measures; Modeling; Morphologic artifacts; Motion; National Institute of Biomedical Imaging and Bioengineering; Noise; Optics; Outcome; Parents; Patients; Pattern; Photons; Preventive measure; Process; Radiation Dose Unit; Readiness; Research; Resolution; Risk; Roentgen Rays; Selenium; Signal Transduction; Small Business Innovation Research Grant; Source; Spottings; Stress Tests; System; Techniques; Technology; Tellurium; Testing; Thinness; Transistors; Uninsured Medical Expense; United States National Institutes of Health; Variant; X-Ray Computed Tomography; X-Ray Medical Imaging; cardiovascular disorder risk; commercialization; coronary artery calcium; cost; cost comparison; density; detector; electric field; electrical property; electronic structure; high risk; improved; industry partner; innovation; manufacture; manufacturing process; new technology; novel; parent project; programs; prototype; quantum; screening; success; theories; trend

ABSTRACT Cardiovascular disease (CVDs) are the leading cause of death globally. According to the American Heart Association, for early treatment of CVD and to verify if a patient should be prescribed statin therapy, calcium scoring via cardiac Computed Tomography (CT) should be performed. However, there is a limited application of calcium scoring due to limited spatial resolution of CT (~1 mm), dose concern, and out of pocket expense for patient. To address the challenges with CT calcium scoring, a new technology based on dual-layer flat panel detector is being developed under our R01 “A dual-layer flat panel X-ray detector based on an engineered amorphous chalcogenide alloy for quantifying coronary artery calcium” to provide opportunistic calcium score whenever X-ray is done. This technology aims to provide an opportunistic approach to X-ray imaging with a detector that improves detection and quantification of coronary artery calcium (CAC). It is based on a patent pending selenium alloy with favorable optical and electrical properties that enhance image quality. Whenever X- ray is done for any reason calcium score automatically is generated with no additional cost burden to healthcare system. To advance the proposed technology from a functioning prototype to readiness level required for licensing to the Original Equipment Manufacturer (OEM), there are areas related to uniformity and variation across detector and yield that should be evaluated and assessed. In this supplement, we will apply our learning from concept to clinic: commercializing innovation (C3i) program to address key areas that are not included in the parent award but needs to be address before being presented to OEM partner. We will develop multiple prototypes to assess the distribution of bad pixels and overall detector yield, as well as identifying any patterns or trends in the distribution of these defects. We will determine the required changes or challenges in integration of the proposed technology to the OEM thin-film transistor backplanes. Leveraging the outcome of this supplement award will significantly strengthen the preliminary data required to address important technical risk related to manufacturing process of the proposed technology to present to OEM partners.

抽象的 心血管疾病（CVD）是全球死亡的主要原因。根据美国的心 关联，以早期治疗CVD并验证是否应开处方他汀类药物治疗，钙 应通过心脏计算机断层扫描（CT）进行评分。但是，有限的应用 由于CT的空间分辨率有限（〜1毫米），剂量关注和零用费用，钙评分有限 病人。为了解决CT Calcium评分的挑战，这是一种基于双层平板的新技术 检测器正在我们的R01下开发“基于工程的双层平板X射线检测器 无定形葡萄糖核化合金，用于量化冠状动脉钙以提供机会性钙评分 每当完成X射线时。该技术旨在通过一个机会提供机会主义的方法来利用 改善冠状动脉钙（CAC）的检测和定量的检测器。它是基于专利 持续的硒合金具有有利的光学和电气性能，可增强图像质量。每当x- 射线是由于任何原因自动产生的，而钙得分是自动产生的，而伯恩伯恩没有额外的费用 系统。将提议的技术从功能的原型推向准备水平 给原始设备制造商（OEM）的许可，有一些与均匀性和变化有关的领域 跨检测器和应评估和评估的产量。 在此补充中，我们将将学习从概念应用于诊所：商业化创新（C3I）计划 要解决父母奖励中未包括但需要解决的关键领域 致OEM合作伙伴。我们将开发多种原型来评估不良像素和整体检测器的分布 产量，并确定这些缺陷分布的任何模式或趋势。我们将确定 将提议的技术集成到OEM薄膜晶体管中所需的更改或挑战 背板。利用此补充奖的结果将大大加强初步数据 需要解决与拟议技术的制造过程有关的重要技术风险 出席OEM合作伙伴。