Complex differential spectral interferometry

复微分光谱干涉测量

• 批准号: 6787892
• 负责人: DANIEL J KANE
• 金额: $ 10.16万
• 依托单位: SOUTHWEST SCIENCES, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-15 至 2005-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6787892
• 关键词: angiography; artery; atherosclerotic plaque; bioimaging /biomedical imaging; biomedical equipment development; biopsy; cardiovascular imaging /visualization; clinical biomedical equipment; diagnosis design /evaluation; diagnosis quality /standard; early diagnosis; fiber optics; image enhancement; image guided surgery /therapy; interferometry; microsurgery; neoplasm /cancer diagnosis; preneoplastic state; rapid diagnosis; veins

DESCRIPTION (provided by applicant): This SBIR project will develop a rapid, high resolution optical imaging method for clinical and biomedical applications including imaging of arterial and venous structures s atherosclerotic plaques, detection of cancerous and pre-cancerous tissues, optical guidance during microsurgery and optical biopsy. The method, complex differential spectral interferometry (CDSI), is a frequency domain optical tomography method that is an improvement over both time domain optical coherence tomography (OCT) and spectral interferometry (SI). Like these other methods, CDSI can be easily used with fiber optics and incorporated into endoscopes, catheters and similar devices for in vivo applications. However, CDSI instrumentation is less complex, has I faster imaging rates and a potentially better dynamic range. Ultimately, an imaging system that provides I both spectroscopic and structural information with ten micrometer or better resolution will be developed for in vivo diagnostic imaging and tissue biopsy.

描述（由申请人提供）： 该SBIR项目将为临床和生物医学应用开发一种快速、高分辨率的光学成像方法，包括动脉和静脉结构动脉粥样硬化斑块的成像、癌变和癌前组织的检测、显微外科手术和光学活检期间的光学引导。该方法称为复差分光谱干涉测量（CDSI），是一种频域光学断层扫描方法，是对时域光学相干断层扫描（OCT）和光谱干涉测量（SI）的改进。与这些其他方法一样，CDSI 可以轻松地与光纤一起使用，并集成到内窥镜、导管和类似的体内应用设备中。然而，CDSI 仪器不太复杂，具有更快的成像速率和可​​能更好的动态范围。最终，将开发一种能够提供十微米或更高分辨率的光谱和结构信息的成像系统，用于体内诊断成像和组织活检。

项目成果

Resolving the complex conjugate ambiguity in Fourier-domain OCT by harmonic lock-in detection of the spectral interferogram.

• DOI: 10.1364/ol.31.001271
• 发表时间: 2006-05
• 期刊: Optics letters
• 影响因子: 3.6
• 作者: A. Vakhtin;K. Peterson;D. Kane

Demonstration of complex-conjugate-resolved harmonic Fourier-domain optical coherence tomography imaging of biological samples.

• DOI: 10.1364/ao.46.003870
• 发表时间: 2007-06
• 期刊: Applied optics
• 影响因子: 1.9
• 作者: A. Vakhtin;K. Peterson;D. Kane