Complex differential spectral interferometry

复微分光谱干涉测量

• 批准号: 6787892
• 负责人: DANIEL J KANE
• 金额: $ 10.16万
• 依托单位: SOUTHWEST SCIENCES, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-15 至 2005-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6787892
• 关键词: angiography; artery; atherosclerotic plaque; bioimaging /biomedical imaging; biomedical equipment development; biopsy; cardiovascular imaging /visualization; clinical biomedical equipment; diagnosis design /evaluation; diagnosis quality /standard; early diagnosis; fiber optics; image enhancement; image guided surgery /therapy; interferometry; microsurgery; neoplasm /cancer diagnosis; preneoplastic state; rapid diagnosis; veins; angiography; artery; atherosclerotic plaque; bioimaging /biomedical imaging; biomedical equipment development; biopsy; cardiovascular imaging /visualization; clinical biomedical equipment; diagnosis design /evaluation; diagnosis quality /standard; early diagnosis; fiber optics; image enhancement; image guided surgery /therapy; interferometry; microsurgery; neoplasm /cancer diagnosis; preneoplastic state; rapid diagnosis; veins

DESCRIPTION (provided by applicant): This SBIR project will develop a rapid, high resolution optical imaging method for clinical and biomedical applications including imaging of arterial and venous structures s atherosclerotic plaques, detection of cancerous and pre-cancerous tissues, optical guidance during microsurgery and optical biopsy. The method, complex differential spectral interferometry (CDSI), is a frequency domain optical tomography method that is an improvement over both time domain optical coherence tomography (OCT) and spectral interferometry (SI). Like these other methods, CDSI can be easily used with fiber optics and incorporated into endoscopes, catheters and similar devices for in vivo applications. However, CDSI instrumentation is less complex, has I faster imaging rates and a potentially better dynamic range. Ultimately, an imaging system that provides I both spectroscopic and structural information with ten micrometer or better resolution will be developed for in vivo diagnostic imaging and tissue biopsy.

描述（由申请人提供）： 这个SBIR项目将开发一种快速，高分辨率的光学成像方法，用于临床和生物医学应用，包括动脉和静脉结构的成像，动脉粥样硬化斑块，检测癌性和癌前组织，微体外期间的光学指导以及光学生物检查。该方法是复杂的微分光谱干涉法（CDSI），是一种频域光学断层扫描方法，它比时域光学相干断层扫描（OCT）和光谱干涉法（SI）的改进。与这些其他方法一样，CDSI可以轻松地与光纤一起使用，并将其掺入内窥镜，导管和类似的体内应用设备中。但是，CDSI仪器不那么复杂，我的成像速率更快，动态范围更高。最终，将开发出具有十微米或更好分辨率的光谱和结构信息的成像系统，用于体内诊断成像和组织活检。