Development of Conduct Problems: Genetic and Environmental Interface

行为问题的发展：遗传与环境的相互作用

• 批准号: 7034754
• 负责人: Laura A Baker
• 金额: $ 69.61万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-01-05 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7034754
• 关键词: adolescence (12-20); age difference; aggression; antisocial personality; behavioral /social science research tag; behavioral genetics; child behavior disorders; child psychology; clinical research; disease /disorder onset; family genetics; family structure /dynamics; gene environment interaction; human subject; longitudinal human study; mental health epidemiology; middle childhood (6-11); neuropsychological tests; parent offspring interaction; peer group; psychometrics; questionnaires; twin /multiplet

DESCRIPTION (provided by applicant): We have implemented a major longitudinal twin study of aggression and antisocial behavior (ASB) and its social and biological risk factors (#MH58354). Based on two waves of data collected at ages 9-10 (Wave 1) and 11-12 (Wave 2), we study genetic and environmental variations in childhood conduct problems, and how these vary across gender, rater, and definition of ASB. Relationships of ASB with known risk factors (social and biological) have been confirmed, and new relationships have been identified. The extent to which risk factor/ASB relationships are mediated by environmental and/or genetic factors is studied and is of key importance to future intervention. We propose to extend the study to include 2 additional waves of assessment at ages 14-15 (Wave 3) and 16-17 (Wave 4), to obtain comprehensive measures of antisocial and aggressive behavior and their risk factors for these same children during adolescence. The primary aim of the next phase is to understand environmental, genetic, and phenotypic continuities in ASB and its biological and social risk factors from age 9-17. The first 5-year phase provided comprehensive assessments of behavioral, neurocognitive, social, and psychophysiological function during two waves of investigation. In Wave 1, twins and their primary caregivers participated in the most extensive assessment, including structured interviews about behavior and psychosocial risk factors, neurocognitive testing, and psychophysiological responses (cardiovascular, electrodermal, electrocortical, and electromyographic) during rest periods and a variety of tasks (attention and emotion-related). A follow-up assessment in Wave 2 focused primarily on children's' behavior and social risk factors (peer and family characteristics), with a limited psychophysiological recording (autonomic measures only). Adding two more waves of data collection during adolescence will provide the most comprehensive, prospective longitudinal data on ASB ever obtained in a genetically informative design. This four-wave, 10 year longitudinal twin study will provide the unique opportunity to understand how genes and environment combine and interact to produce antisocial outcomes in children and adolescents. In this revised application, clarifications of theoretical framework and a detailed plan for analyses are provided. The data analysis core staff has been expanded to assist in the complex phenotypic and genetic analyses that will ensue from this rich and unique longitudinal dataset.

描述（由申请人提供）：我们已经实施了对侵略性和反社会行为（ASB）及其社会和生物危险因素的重大纵向双胞胎研究（＃MH58354）。基于在9-10岁（第1波）和11-12（第2波）中收集的两个数据波，我们研究了儿童行为问题的遗传和环境变化，以及它们在ASB的性别，评估者和定义之间如何变化。已经确认了ASB与已知危险因素（社会和生物学）的关系，并确定了新的关系。研究了由环境和/或遗传因素介导的危险因素/ASB关系的程度，对于将来的干预至关重要。我们建议将研究扩展到14-15岁（第3波）和16-17（波第4波）的额外评估浪潮，以获取对青春期期间这些儿童的反社会和侵略行为的全面度量。下一阶段的主要目的是了解ASB的环境，遗传和表型连续性及其从9-17岁开始的生物学和社会风险因素。在两次研究浪潮中，第一个5年阶段提供了对行为，神经认知，社会和心理生理功能的全面评估。在第一波中，双胞胎及其主要护理人员参与了最广泛的评估，包括有关行为和心理心理风险因素的结构化访谈，神经认知测试以及心理生理学反应（心血管，电某些，电皮质和触摸术）在休息期和各种任务（注意和情绪和情感上）。第2波的后续评估主要集中在儿童的行为和社会风险因素（同伴和家庭特征）上，其心理生理记录有限（仅自主措施）。在青春期中增加了两次数据收集浪潮将提供有关在遗传信息丰富的设计中获得的最全面，最具前瞻性的纵向数据。这项为期四波，十年的纵向双胞胎研究将为了解基因和环境如何结合和相互作用以在儿童和青少年中产生反社会结果的独特机会。在此修订的应用程序中，提供了理论框架和详细的分析计划。数据分析核心人员已被扩展，以协助这个丰富而独特的纵向数据集进行复杂的表型和遗传分析。