RISK FACTORS FOR ANTISOCIAL BEHAVIOR

反社会行为的风险因素

• 批准号: 6627603
• 负责人: Laura A Baker
• 金额: $ 54.69万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-01-05 至 2004-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6627603
• 关键词: adolescence (12-20); aggression; antisocial personality; behavioral /social science research tag; child psychology; clinical research; disease /disorder etiology; disease /disorder proneness /risk; family structure /dynamics; gender difference; gene environment interaction; human genetic material tag; human subject; longitudinal human study; middle childhood (6-11); monozygotic twins; neuropsychological tests; outcomes research; parent offspring interaction; prognosis; psychometrics; psychophysiology; twin /multiplet

Human aggression and antisocial behavior are known to be the product of both social and biological risk factors. What is not yet understood is how environment and genetic factors may mediate the interrelationships among these risk factors and antisocial outcomes. A study of twins and their families would provide the ideal opportunity to answer the critical question in this regard: Do measured social and biological variables relate to antisocial development for environment or genetic reasons? Our ability to develop effective and efficient interventions for antisocial behavior rest heavily upon the answer to this question. A study of normal variation in antisocial and aggressive behavior is proposed for 600 twin pairs (both male and female), aged 9-10 years old during an initial assessment, and aged 11-12 years old during a follow-up assessment. The study will provide the first opportunity to investigate the environmental and genetic underpinnings of important social and biological risk factors for unlawful, antisocial and aggressive behavior in boys and girls on the risk of adolescence. Social risk factors will include aspects of the family environment, such as socio-economic status, emotional climate, cohesion, parental warmth and affection, parental supervision, discipline and control. Specific environmental factors for each twin will also be studied including individual relationships with each family member, as well as peer-group characteristics. Biological risk factors will include psychophysiological indicators of arousal (both electrodermal and cardiac channels), as well as neuropsychological and cognitive testing. Both the social and biological risk factors studied here have previously been shown to distinguish between children at high and low risk for aggressive and antisocial behavior. The twin design allows the unique occasion to estimate the relative contributions of environmental and genetic factors to both antisocial behavior and their risk factors, as well as their interrelationships. Of particular importance are whether the links between antisocial behavior with biological and social risk factors, if they exist in this sample, are mediated by genetic or environmental factors. DNA samples will be extracted through mouthwash procedures and will serve two purposes. First, zygosity determination will be made using PCR tests for the 400 same-sex pairs. Then, the remaining DNA will be stored for future analyses of specific genetic loci hypothesized to show associations with antisocial behaviors. We anticipate that by the end of this project, a substantial number of candidate genes will be suggested for antisocial outcomes. At that point, additional funding will be sought to confirm these associations using the rich data source resulting from this project. Detailed knowledge of the underlying biological and genetic mechanisms in aggressive and other forms of antisocial behavior will lead to a greater understanding of how social variables in turn are related to antisocial outcomes, ultimately enabling greater control of this important social phenomenon.

人类的侵略和反社会行为是社会和生物危险因素的产物。尚不清楚的是环境和遗传因素如何介导这些危险因素和反社会结果之间的相互关系。对双胞胎及其家人的研究将提供理想的机会来回答这一关键问题：在环境或遗传原因出于环境或遗传原因，测量的社会和生物变量是否与反社会发展有关？我们为反社会行为开发有效和有效的干预措施的能力在很大程度上取决于对此问题的答案。 提出了对反社会和侵略性行为正常变异的研究，该研究是针对600对（男性和女性）的600对，在初次评估中年龄9-10岁，在随访评估中年龄11-12岁。该研究将为研究青春期风险的男孩和女孩的非法，反社会和侵略行为的重要社会和生物风险因素的环境和遗传基础提供第一个机会。社会风险因素将包括家庭环境的各个方面，例如社会经济地位，情感气氛，凝聚力，父母的温暖和感情，父母的监督，纪律和控制。还将研究每个双胞胎的特定环境因素，包括与每个家庭成员的个人关系以及同行组的特征。生物学危险因素将包括唤醒的心理生理学指标（既有电肌管和心脏通道），以及神经心理学和认知测试。此处研究的社会风险因素和生物学风险因素均已证明，以区分具有侵略性和反社会行为风险的儿童。双胞胎设计允许独特的场合估算环境和遗传因素对反社会行为及其风险因素及其相互关系的相对贡献。特别重要的是，反社会行为与生物学风险因素之间的联系是否存在于该样本中，是由遗传或环境因素介导的。 DNA样品将通过漱口水方法提取，并将有两个目的。首先，将使用400个同性对的PCR测试进行Zygosity确定。然后，将存储其余的DNA，以将来对假设显示与反社会行为的关联的特定遗传基因座进行将来的分析。我们预计，到该项目结束时，将为反社会结果提出大量候选基因。当时，将寻求额外的资金，以使用该项目产生的丰富数据源来确认这些关联。对侵略性和其他形式的反社会行为中潜在的生物学和遗传机制的详细知识将使人们对社会变量如何与反社会结果有关，最终使对这一重要社会现象的控制权更大。